Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"TSEN"”.
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Functions of The Trna Splicing Endonuclease and Other Adventures In Rna Processing
<p>The tRNA splicing endonuclease (TSEN), has been studied for over three decades for its function in tRNA splicing. However, this enzyme has other functions that are just beginning to be characterized. Mutations in TSEN cause the neuronal disease pontocerebellar hypoplasia (PCH) that is …
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Structure and Function Studies on tRNA Splicing Endonuclease
… step is performed by tRNA splicing endonuclease (TSEN), a highly conserved heterotetramer with two catalytic and two structural subunits. In addition to this conserved function, archaeal TSEN also processes pre-rRNA and yeast TSEN cleaves some mRNAs that encode mitochondrial proteins to initiate …
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Sanctuary imagery in Hebrews 10:19-20 as a reflection of early Christians' understanding of Christ's high priesthood
This dissertation examines the relationship between the cultic languages in Hebrews 10:19-20 and the sanctuary imagery of the Synoptic Gospels (Matt 27:53/Mark 15:38/Luke 23:45). The work consists of six chapters. The first chapter provides a survey of the history of research regarding the …
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Design and development of an automated metered dose inhaler (MDI) for asthmatic patient
To date, infant with illness associated with the pulmonary airway is treated by a doctor using a spacer device with metered dose inhaler (MDI) to allow the infant to breathe in the medication known as salbutamol. Current asthma spacer does not provide systematic way of monitoring and displaying the …
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Designing an enhanced web user experience: the use of "emotional probes" as a user-centred methodology for designing emotionally-engaged web interaction.
This research project explores the importance of balancing aesthetics and usability of Web design to enhance user experience. It aims to develop an effective methodology to better understand the dimensions of users' emotions, experienced in interaction with Web pages. The proposed methodological …
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FPGA Prototyping Framework on ARROW SoCKit Board with Xillybus Interface and Standard FIFO
Field Programmable Gate Array (FPGA) has been a popular candidate in hardware acceleration for offloading compute-intensive tasks from the traditional microprocessors. Due to the parallel nature, algorithm functions implemented on FPGAs can provide acceleration and are more energy efficient than …
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The Deconstruction of Reinforcement Learning in Human Substance Use Disorder
Individuals diagnosed with substance use disorder (SUD) often behave in ways detrimental to their own interest and well-being. The mechanisms behind such maladaptive behaviour in human SUD remain unclear, but can be explained by disruptions to reinforcement learning processes that under normal …
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The design of whispering gallery mirrors for soft x-ray lasers
Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1988.
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Mechanisms of flashover of contaminated insulators.
Massachusetts Institute of Technology. Dept. of Electrical Engineering. Thesis. 1974. Sc.D.
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Exploring overt and covert interpersonal exploitation from the perspective of power
Interpersonal exploitation—defined as depriving others of resources while enhancing one's own (Buss and Duntley, 2008)—is a topic that is prevalent in the workplace but less addressed in research. This dissertation takes a strategic and instrumental view to examine who, why, and in which way the …
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Comparison and Investigation of Solar Spectral Irradiance with Solar Aspect Monitor
On-board the International Space Station (ISS), the Remote Atmospheric and Ionospheric Detection System (RAIDS) is a suite of limb-scanning monitors taking measurements from the extreme ultraviolet (EUV) to the near infrared (NIR). A single-scattering Rayleigh model is developed to eliminate the …
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Influence of a liquid crystalline block on the microstructure and optical properties of block copolymers
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1997.
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Functions of RNA exosome and tRNA splicing ligase in Mendelian and Infectious diseases
… involves cleavage by tRNA splicing endonuclease (TSEN), resulting in 5’ exon, 3’ exon, and intron fragments. Fungi use a “heal and seal” pathway that requires three distinct catalytic domains of the tRNA ligase enzyme, Trl1. In contrast, humans use a “direct ligation” pathway carried out by RTCB, …