Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"TRPV4"”.
-
Funktionelle Interaktion von Polycystin 2 und TRPV4
… funktionelles Zusammenwirken mit Polycystin 2. TRPV4, ein osmo- und mechanosensitiver Ionenkanal aus der TRP-Familie mit einem ähnlichen Verteilungsmuster wie Polycystin 2 in Geweben sowie auf subzellulärer Ebene, zeigte eine deutliche Beeinflussung in seinen Ionenkanaleigenschaften durch die …
-
Investigating the Role of TRPV4 as a Mechanoreceptor in the Intervertebral Disc
… Potential Cation Channel Subfamily V Member 4 (TRPV4) is a cell membrane Ca2+ channel that regulates intracellular calcium levels in response to mechanical stimuli. Recent studies have demonstrated that TRPV4 is required for the induction of extracellular gene expression in murine intervertebral …
-
TRPV4 in the Choroid Plexus Epithelium: Pathway Analysis and Implications for Cerebrospinal Fluid Production
… blood. Transient Receptor Potential Vanilloid-4 (TRPV4) is a nonselective Ca2+-permeable cation channel expressed in the CP which is being investigated for its role in CSF production. To study hydrocephalus, we utilize two model systems; the TMEM67-/- Wpk rat, and the PCP-R cell line. The Wpk rat …
-
Functional Characterization of the Mammalian TRPV4 Channel: Yeast Screen Reveals Gain-of-Function Mutations
… of mammalian TRP channels tested, only wild type TRPV4 rescued the ability of the yeast strain trk1Δ trk2Δ to grow on low potassium media. The TRPV4 channel is important in thermosensitive, osmosensitive, and mechanosensitive processes; recently, mutations of TRPV4 have been linked to human …
-
Regulation of Functional Expression of Mechanosensitive Trpv4 Channel In The Distal Nephron By Dietary Potassium and Sodium Intake
<p>The Ca<sup>2+</sup>-permeable TRPV4 channel is predominantly expressed in the distal nephron (DN) and its activity is essential for [Ca<sup>2+</sup>]<sub>i</sub> elevations in response to increased tubular flow. Here, I probed the physiological mechanisms controlling TRPV4 function and …
-
Role of Transient Receptor Potential (TRP) Channels in Nociception
… study, I have characterized the properties of TRPV4, a putative mechanosensitive ion channel expressed in dorsal root ganglion (DRG) neurons and nonsensory tissues. First, I have investigated the expression and function of TRPV4 and TRPV1 in the DRG neuronal cell bodies as well as their central …
-
Neuroepithelial Signalling in the Colon
… management remains an unmet clinical challenge. TRPV4 is a member of the vanilloid subtype of transient receptor potential ion channels and possesses pronociceptive functions in the bowel. Our recent single-cell RNA sequencing study revealed a relative paucity of TRPV4 mRNA within colonic sensory …
-
Molecular Mechanisms of Itch Sensations
… S100a8, CALR and DSP) and one both-dependent: TRPV4) itch genes. Atp2a1 and Itpr3 were selected for further characterization. Atp2a1 and Itpr3 are involved in GRPR downstream Ca2+ signaling pathway for histamine-independent itch. GRPR is also expressed in peripheral tissues such as dorsal root …
-
ATP, TRP channels and airway neuronal sensitisation
… Acute ATP priming of PNEs resulted in heightened TRPV4 responses at a particular GSK1016790A (TRPV4 agonist) concentration indicating hyperresponsivess of TRPV4 that could be prevented by the P2X3 inhibitor AF-353; however, hypersensitation of the TRPV4 dose response curve with ATP priming was not …
-
Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… cation channel, subfamily vanilloid, member 4 (TRPV4) antagonist (RN1734) ameliorates hydrocephalus in a rat model of congenital hydrocephalus (Tmem67 model). It was hypothesized that targeting this mechanosensitive ion channel may slow production of CSF by targeting the CP. However, …
-
Bases moleculares de la propiocepción
… receptor de potencial transitorio vanilloide 4 (TRPV4) y PIEZO2, pero todos los estudios han sido realizados en modelos murinos y no existen datos en humanos.
-
Function and pharmacology of TRPM3 ion channel
… of other sub-types of mammalian TRP, TRPC5 or TRPV4. The data validate E3-targeting as an approach for production of isoform-specific channel blockers and reveal a specific agent for blocking TRPM3. The cellular and tissue functions of TRPM3 were also investigated. RT-PCR and …
-
Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
… of these channels including TRPV1, TRPV2, TRPV4, TRPA1, TRPM7, TRPM8, and more. The channels’ direct implication in synovial fibroblast aggressive phenotype is becoming better understood and shows promise for TRP channels as therapeutic targets. My master’s thesis will focus on TRP channel …
-
Enhancing Chondrocyte Biosynthetic Activities: Harnessing the Power of Loading-Induced Evolved Temperature
… (TREK1) and mechano-gated ion channels (TRPV4), further elucidating underlying thermo-mechanotransduction mechanisms. Expanding on these insights, we next shift our focus to the intricate relationship between loading-induced evolved temperature and hypoxia, another pivotal factor known to …
-
The mechanisms of aquaporin expression and translocation in cerebral pathologies
… on the transient receptor potential vanilloid 4 (TRPV4) channels, calcium and calmodulin activation. Investigation into the role of AQP expression and regulation in temporal lobe epilepsy (TLE) was conducted using transcriptomic (microarray, RT-qPCR) and proteome profiling of matched human …