Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"TRPV2"”.
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Structural and Dynamic Proximal Proteomic Analysis of TRPV2 Ion Channel Activation
… Transient receptor potential vanilloid type 2 (TRPV2) ion channels are calcium-permeable, tetrameric ion channels with implications in several cellular processes such as immune response, neuronal development, and multiple cancers. Despite the impact of TRPV2 on varying physiologies, there is …
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ATP, TRP channels and airway neuronal sensitisation
… the expression and role of mechanosensitive TRPV2 in the bronchial epithelium. Extracellular ATP levels are increased in the COPD airway. ATP is a potent tussive agent acting via the purinergic P2X3receptor on airway nerves.<br/><br/>In chapter 3 it was hypothesised that TRPV2 is expressed in …
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Distribution and function of TRP ion channels in primary sensory neurons
… a large number of nerves. The TRP ion channels TRPV2 and TRPM8 are expressed in the somatosensory nervous system in animals and are therefore likely to be expressed in humans as well. Fluorescence immunohistochemistry was used to identify these channels and compare their expression and …
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Mechanisms of thermal sensitivity in rodent primary afferent neurons innervating the skin
… a significant role is detecting noxious cold. TRPV2 is another heat activated ion channel. The sensory phenotype of TRPV2 knock-out mice was studied and compared against TRPV2 wild-type mice in both hairy and glabrous skin. Mice lacking TRPV2 had normal heat sensitive nociceptors and afferents …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… them, suggestive of involvement of either TRPV2, TRPV3 or TRPM6. Since the rises were neither reduced by tranilast (TRPV2 blocker) nor NS8593 (TRPM6 blocker) it strongly suggests an involvement of TRPV3 in the cation rise in DP thymocytes. In support of this notion is the sensitization by …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… them, suggestive of involvement of either TRPV2, TRPV3 or TRPM6. Since the rises were neither reduced by tranilast (TRPV2 blocker) nor NS8593 (TRPM6 blocker) it strongly suggests an involvement of TRPV3 in the cation rise in DP thymocytes. In support of this notion is the sensitization by …
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Dilations of the Endoplasmic Reticulum Contribute to Spongiform Degeneration and Unlock a Door to a Unified Model of Neuropathological Features in Prion Diseases
… the transient receptor potential vanilloid 2 (TRPV2) calcium leak channel in this vacuolation process. Finally, we demonstrated that ER dilations contribute to spongiform degeneration in prion disease by directing a fluorescent marker to the lumen of these vacuoles in cryo-sectioned brains. We …
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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
… of several of these channels including TRPV1, TRPV2, TRPV4, TRPA1, TRPM7, TRPM8, and more. The channels’ direct implication in synovial fibroblast aggressive phenotype is becoming better understood and shows promise for TRP channels as therapeutic targets. My master’s thesis will focus on TRP …