Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"TRPV1"”.
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TRPV1 ist ein polymodaler Rezeptor von nozizeptiven Spinalganglienzellen
… Mäusen untersucht, bei denen das Gen für TRPV1 (transient receptor potential V1) deletiert wurde. Das Ergebniss wurde mit den Daten von Wildtyp Mäusen verglichen. TRPV1 (früher VR1; vanilloid receptor 1) wird nahezu selektiv in sensiblen Neuronen exprimiert und wird im heterologen …
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THE RESPIRATORY RESPONSE OF TRPV1 KNOCKOUT MICE TO TRIGEMINAL IRRITANTS
… stimulation is known for only a few compounds. TRPV1 channels, for example, are activated by capsaicin. The present study was designed to address this question. Classic experiments have established that exposure to upper respiratory tract irritants results in a systematic alteration in the …
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Murine Phenotype Analyses and the Role of TRPV1 in Hypoxia
… of transient receptor potential vanilloid 1 (TRPV1) function blunts the thermoregulatory, ventilatory and metabolic responses to hypoxia. Mice were implanted with intraperitoneal transmitters for chronic recording of HR, Tb and ACT. The animal environment study consisted of a 3-week protocol …
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Trpv1 Channels Contribute to Behavioral Hypersensitivity and Spontaneous Activity In Nociceptors After Spinal Cord Injury
… of ion channel transient receptor vanilloid 1 (TRPV1) has been observed in the dorsal horn of the spinal cord after SCI, and reduction of SCI-induced hyperalgesia by a TRPV1 antagonist has been claimed. However, the possibility that SCI enhances TRPV1 expression and function in nociceptors has …
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Structural Analysis of Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channel Protein and Proline Mimics using Computational Techniques
… Receptor Potential Vanilloid Type 1 (TRPV1) is part of the TRP family gated by vanilloids, heat and protons.<sup>2</sup> Molecular modeling will be used in order obtain structural and functional data on TRPV1 in its membrane bound environment. In particular, the transmembrane and …
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Studies on transient receptor potential vanilloid subtype 1 (TRPV1)-mediated degeneration of mesencephalic cellsin vivo and in vitro
… receptor potential vanilloid subtype 1 (TRPV1, also known as VR1) has an oligomeric structure formed by subunits having six transmembrane segments with a pore domain formed by the fifth and sixth transmembrane regions. This receptor is a nonselective cation channel activated by the …
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Capsinoids, Non-Pungent TRPV1 Agonists, Induce a Mild Hypothermia That Provides Short- and Long-Term Neuroprotection After Ischemic Stroke
… after stroke. Capsinoids function as TRPV1 agonists. However, unlike capsaicin, capsinoids are vulnerable to esterase-mediated breakdown, thus significantly restricting their action to the site of delivery. We showed that capsinoids delivered intraperitoneally (IP) to mice induced a …
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Bioactive Lipids in Nociception
… and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a known …
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Activation of the Transient Receptor Potential Vanilloid-1 (TRPV1) channel mediates Extracellular Signal Regulated Kinase (ERK) phosphorylation via Beta-arrestin-2 signaling
The Transient Receptor Potential Vanilloid 1 (TRPV1) channel plays a pivotal role in pain sensation and transduction under physiological and pathophysiological conditions. Recent work highlighted a possible role for β-arrestin-2, a scaffolding protein that mediates G-protein coupled receptor …
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… receptor potential vanilloid subtype 1 (TRPV1) leads to neuroprotective effects by anti-inflammtory action. The main purpose of this thesis is to investigate the functional effects of capsaicin (CAP), the TRPV1 agonist, in LPS-induced in vivo PD model. To do that, we investigated the …
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Endocannabinoid regulation of gastric vagal afferent signalling
… transient receptor potential vanilloid 1 (TRPV1) knockout mice also show decreased GVA tension receptor sensitivity. Endocannabinoids (ECs) regulate appetite via cannabinoid 1 (CB1) receptors and are also endogenous ligands for TRPV1. The CB1 receptor and TRPV1 are expressed on GVAs and the …
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Noninvasive Neuromodulation via Ultrasonic Activation of Endogenous and Exogenous Ion Channels
… the ultrasound-sensitive ion channels, including TRPV1 and TRPM2, are the key molecular sensors for ultrasound neuromodulation. Chemical blocker and genetic knockdown of the TRPM2 and TRPV1 in the hypothalamus significantly suppressed the ultrasound-induced torpor effect. Overexpression of TRPM2 …
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Protonenempfindlichkeit von Spinalganglienneuronen bei Wildtypmäusen und Mausmutanten mit einem Mangel an TRPV 1 oder ASIC 3
… den in diesem Zusammenhang entdeckten Kanälen TRPV1 und ASIC3 auf die Protonensensitivität von nativen Spinalganglienneuronen, sowie Unterschiede zwischen der IB4-positiven und der IB4-negativen Population untersucht. Hierzu wurden Patch-Clamp-Studien an isolierten Neuronen von …
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Group III mGluR8 negatively modulates TRP channels
… group III mGluRs (mGluR8) and two TRP channels: TRPV1 and TRPA1. In the first study, we examined the interaction between group III mGluRs and TRPV1. Anatomical studies demonstrated that group III mGluR8 is expressed on cutaneous axons and is co-localized with TRPV1 in the dorsal root ganglia …
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Antiproliferative activities of Euphorbia bicolor (euphorbiaceae) and Maclura pomifera (moraceae) extracts on estrogen receptor-positive and triple-negative breast cancer cell lines
… the transient receptor potential vanilloid 1 (TRPV1) ion channel as a promising target for cancer treatment. This study explores the antiproliferative properties and mechanisms of action of phytochemicals from two native plants, Maclura pomifera and Euphorbia bicolor, in breast cancer cell …
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MODULATION OF SYNAPTIC TRANSMISSION AT THE NUCLEUS TRACTUS SOLITARIUS
… the hypothesis that nociceptive TRP channels TRPV1 (vanilloid) and TRPA1 (ankyrin) modulate synaptic transmission in the NTS. As a result of this modulation, the efferent functions that control autonomic and visceral functions will be regulated and account for the changes in autonomic …
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Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
… transient.receptor.potential.vanilloid.type.1 (TRPV1) channel and sensory neuropeptides calcitonin.gene-related.peptide (CGRP) and substance.P (SP) were studied in L4-L5 dorsal root ganglia (DRGs), spinal cord and sciatic nerve using western blot (WB), immunohistochemistry, and reverse …
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Role of Transient Receptor Potential (TRP) Channels in Nociception
… to be involved in inflammation-induced pain. TRPV1 is extensively studied and it is specifically involved in inflammatory thermal hypersensitivity. Mechanical hypersensitivity is one of the significant components of nociception. Several receptors have been proposed to underlie …
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Distribution and function of TRP ion channels in primary sensory neurons
… of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. The CB1 receptor agonists anandamide and HU210 …
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