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Showing 1 to 2 of 2 for “"TRPML3"”.
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Targeting Sequence and Function-Dependence of Subcellular Localization of Transient Receptor Potential Mucolipin Channels and Characterization of Engineered Molecule Probes For Detecting Lysosomal Calcium Release
<p>Both TRPML1 and TRPML3 are members of the mucolipin subfamily of Transient Receptor Potential (TRP) channels. They have been implicated in endolysosomal functions such as divalent cation release, luminal pH regulation, autophagy and vesicle trafficking. Interestingly, whereas TRPML1 is almost …
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Organellar Zn2+ Homeostasis and the Role of TRPML Channels in Neuronal Lysosome Physiology and Axonal Transport
… sensors and GZnP3, we establish that TRPML1 and TRPML3 channels are permeable to physiological concentrations of Zn<sup>2+</sup>. Upon characterizing the location of these channels, we also provide the first direct evidence that TRPML channels can release Zn<sup>2+</sup> from intracellular …