Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"TRPM8"”.
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Structural Studies of the Cold and Menthol Sensing Ion Channel TRPM8
… stimuli. The TRP melastatin subfamily member 8 (TRPM8) has been characterized as the principal molecular sensor in humans for detecting innocuous to noxious cold temperatures. It is also activated by the naturally occurring cooling compound menthol which induces cooling sensation. TRPM8 function …
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Distribution and function of TRP ion channels in primary sensory neurons
… number of nerves. The TRP ion channels TRPV2 and TRPM8 are expressed in the somatosensory nervous system in animals and are therefore likely to be expressed in humans as well. Fluorescence immunohistochemistry was used to identify these channels and compare their expression and distribution …
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Mechanisms and plasticity of cold sensitivity in peripheral neurons
… stimuli in sensory neurons, and two channels, TRPM8 and TRPA1, have been implicated in cold sensation. Ratiometric calcium imaging and quantitative rt-PCR studies revealed that cold sensitivity in sympathetic neurons and in a significant proportion of sensory neurons is independent of TRPM8 and …
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Genome-wide Association Study of TDI-Induced Asthma in a Korean Population : Signofocant Association of a T-catenin(CTNNA3) and TRP channel gene-gene interaction
… (multifactor dimensionality reduction)을 이용하였다. TRPM8의 rs10803666 의 연관성 분석이 유의한 것을 바탕으로 TRPM 가족과 TRPV 가족간의 상호작용을 분석한 후 TRP 채널 가족들의 상호작용을 알아보았다. 결과: CTNNA3 (alpha-T-catenin) alpha-3의 유전적 변이는 TDI 천식표현형에서 유의한 결과를 보였다 (5.84x10-6 for rs10762058, 1.41 x 10-5 for rs7088181, 2.03 x 10-5 for rs4378283). 두 …
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Nociception and the Experience of Pain Signaling Due to Nerve Damage
… Transient Receptor Potential Melestatin 8 (TRPM8), and Cannabinoid Receptor 1 (CNR1). We hypothesize through knockdown of TRPA1, TRPM8, or CNR1 gene function may alleviate chronic pain-based behaviors and pain signaling. Gene manipulation by way of splice site-blocking morpholinos was …
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Mechanisms of thermal sensitivity in rodent primary afferent neurons innervating the skin
… sensitive TRPV1 ion channel and cold sensitive TRPM8 and TRPA1 ion channels. However, the role of the TRPA1 receptor in cold transduction remains controversial. Cold sensitivity of primary afferents in adult rat was studied. Selective TRP channel agonists capsaicin, menthol, and mustard oil were …
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Eisenia hortensis Detects Chemesthetic Irritants through TRP Channels
… that E. hortensis possess TRPA1-like and TRPM8-like channels while lacking functional TRPV1 channels.
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Functional genomic study of the parotoid secretion from Bufo gargarizans
… tryptic peptides were supposed to be a factor of TRPM8, which might have relationship with cancer cells. The results indicated that the discovered tryptic peptides can be potential drug candidates.
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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
… including TRPV1, TRPV2, TRPV4, TRPA1, TRPM7, TRPM8, and more. The channels’ direct implication in synovial fibroblast aggressive phenotype is becoming better understood and shows promise for TRP channels as therapeutic targets. My master’s thesis will focus on TRP channel involvement in …
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Papel de la corriente de freno Ixd en la hipersensibilidad dolorosa al frío inducida por lesión en neuronas sensoriales primarias
… canales iónicos destaca el canal termosensible TRPM8, principal entidad molecular responsable de la generación del potencial de receptor despolarizante que induce el aumento de la frecuencia de disparo ante un descenso de la temperatura en las neuronas sensibles al frío inocuo. Otro canal …