Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"TRPM4"”.
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The Transient Receptor Potential Melastatin 4 Channel: A New Player in Urinary Bladder Smooth Muscle Function
… the transient receptor potential melastatin 4 (TRPM4) channel, a Ca2+-activated, monovalent cation selective channel as a promising novel target for OAB therapies. Until now, the expression and function of the TRPM4 channels in DSM has not yet been explored. Here, we provide the first molecular …
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Improving cancer therapy strategies via cellular stress and immune modulation
… dependent on plasma membrane-localized TRPM4 which induces ATF6-mediate cell death. Immunohistochemical analysis of human OS tissues confirmed that TRPM4 is widely expressed, suggesting that a substantial subset of bone cancer patients may be responsive to ErSO-based therapy. The second …
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Translational development and mechanistic insights into 3-(4- hydroxyphenyl)indoline-2-ones as a potent class of breast cancer therapeutics
… target have revealed the importance of TRPM4, a calcium activated ion channel, to the anticancer activity of these derivatives and this scaffold. Our research suggests that TRPM4 is a direct biological target of this class of molecule, but more evidence of direct binding is being sought …
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Cellular and Circuit Properties of Slow Oscillations In The Thalamic Reticular Nucleus
… transient receptor potential melastatin 4 (TRPM4) channels. Taken together, my results suggest that thalamic circuits can generate slow oscillatory activity, mediated by an interplay of TRN-VB synaptic circuits that generate rhythmicity and TRN cell-intrinsic mechanisms that control PF and …