Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"TRPC3"”.
-
Investigating the role of TRPC3 in the biogenesis of extracellular vesicles
… transient receptor potential (TRP) channel TRPC3 may facilitate Ca2+-mediated EV biogenesis. TRPC3 contributes to the progression of ovarian cancer (OC) in vitro and in vivo, but its role in EV biogenesis and how this influences the pathogenesis of OC is unknown. This thesis therefore aimed …
-
Effects of Chronic Oxidative Stress on TRPM2 and TRPC3 Channels: Potential Implications for Bipolar Disorder
… subtype 2 (TRPM2) and canonical subtype 3 (TRPC3) calcium-permeable non-selective ion channels, already implicated in BD, are involved in calcium and oxidative stress signalling. Thus, I sought to determine whether the expression and function of these channels are modulated by oxidative …
-
Vascular Mechanisms of Rhabdomyolysis-induced Acute Kidney Injury
… 4, 5, and 6 are expressed in renal vessels, with TRPC3 predominant. TRPC3, TRPC6, and TRPC7 are highly homologous. Although the ET system is known to be associated with rhabdomyolysis-induced AKI, the function of renal vascular ion channels in the disease was unclear. Our findings demonstrate that …
-
Angiotensin II signalling in sensory neurons
… be mediated by the non-selective cation channel, TRPC3, activated by the endoplasmic reticulum Ca2+ sensor, STIM. Incubation of sensory neurons with Ang II induced to nuclear translocation of the transcription factor, nuclear factor of activated T-cells 5 (NFAT5). This translocation was dependent …
-
Pharmacological regulation and function of store-operated calcium channels
… but also nonselectively inhibited ORAI1/2/3 and TRPC3/4/5/6 channels.The sensitivity of TRP channels to metal ions was also investigated using patch clamp. Micromolar Cu²⁺ significantly increased the currents of TRPC3/4/5/6 channels. The glutamic acid (E542/E543) and cysteine (C554) residues in …
-
Novel Roles of PACS-1 Within the Nucleus and the Regulated Secretory Pathway
… receptor potential cation channel 3 subfamily C (TRPC3) and extended synaptotagmin 1 (ESyt-1), demonstrating that PACS-1 controls the trafficking of these proteins to the plasma membrane. Furthermore, we identify ESyt-1 as a negative regulator of adrenocorticotropic hormone (ACTH) secretion that …
-
Molecular Determinants of TRP Channel Gating
… central motor axis. The Canonical TRP member 3 (TRPC3) is highly expressed in the cerebellum, where it modulates neuronal activity. Mutation of this channel results in neurodegeneration and ataxia. However, the mechanism by which this occurs is unclear. Accordingly, we utilized functional, …
-
Expression et signalisation des intégrines des cellules glomérulées de la glande surrénale de rat : implication de composantes de la matrice extracellulaire, d'hormones et de canaux ioniques
… les cellules glomérulées expriment les canaux TRPC3 et TRPC6 à la membrane plasmique et que pour TRPC6, la translocation à la membrane plasmique est modulée par différents stimuli tels que l’Ang II (angiotensine II) (5 x 10-7M), l’OAG (1- oleoyl-2-acétylglycérol) (100 pM) et la TG …