Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"TRPA1"”.
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Drosophila TRPA1 controls thermotactic behavior
… (RNAi)-based strategy to identify Drosophila TRPA1 as a key regulator of thermotaxis. Larvae in which dTRPA1 expression has been knocked down with RNAi fail to avoid regions of moderately elevated temperature (~310C--350C).
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Elucidating TRPA1 Ion Channel Aberrations in Oesophageal Adenocarcinoma.
… observed in only few genes, we have identified TRPA1 (Transient Receptor Potential Ankyrin 1) as a novel driver gene in OAC with recurrent mutations in a sequenced cohort of 551 OAC patients. TRPA1 is a ligand-gated, Calcium (Ca2+) -permeable membrane protein, which has recently been implicated …
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Identifying Potential Agonists Of TRPA1 Using A Heterologous Expression System And Transgenic Mice
… receptor proteins, including TRP channels. TRPA1, a highly conserved TRP channel, is known to be activated by over ninety compounds. As TRPA1 is promiscuous in nature, it was considered a likely receptor for stimuli activating the trigeminal nerve. In this study, thirteen stimuli were tested …
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Investigating The Role Of Transient Receptor Potential Ankyrin One (TRPA1) In Cardiovascular Regulation
TRPAl is a member of the TRP superfamily; localised to neural and non-neuronal sites. TRPAl is activated endogenously by products of oxidative stress, where its expression on sensory neurones leads to the release of vasoactive neuropeptides. Exogenous agonists of TRPAl, mustard oil and …
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Evaluation of the Functional Roles of TRPA1 Homologs, Painless and dTRPA1, in Chemical Nociception in Drosophila
… one specific target of these compounds is the TRPA1 channel. Drosophila possess four evolutionary homologs of mammalian TRPA1, two of which are <italic>painless</italic> and <italic>dTRPA1</italic>. These are thought to be involved in chemical nociception, though the specific role of …
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MRGX1-TRPAI in inflammatory pain signalling
… of Transient Receptor Potential Ankyrin 1 (TRPA1). TRPA1 activity can be modulated by G-Protein Coupled Receptors (GPCR), leading to sensitisation and hyperalgesia (enhanced pain sensation), typically seen in inflammatory pain conditions. Human Mas-related G-protein-coupled receptor X1 …
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Σύνθεση αναλόγων των κανναβινοειδών CBD, CBN, CBG, CBC και έλεγχος της δράσης τους στο κανάλι TRPΑ1
… η δράση τους στο κανάλι παροδικού δυναμικού TRPA1 με στόχο να διερευνηθεί ο τρόπος με τον οποίο οι μεταβολές στο μήκος της πλευρικής αλυσίδας επηρεάζουν τη δραστικότητα και τη συγγένεια των ημισυνθετικά παραγόμενων κανναβινοειδών προς τον συγκεκριμένο μοριακό στόχο. Πιο συγκεκριμένα, για την …
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Eisenia hortensis Detects Chemesthetic Irritants through TRP Channels
… a common Transient Receptor Potential 1 (TRPA1) channel agonist, we hypothesized that earthworms possess TRPA1-like channels. We examined whether the earthworm Eisenia hortensis possesses TRPA1-like channels, as well as other TRP channel members. We assessed whether E. hortensis could …
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Chemesthesis in the Earthworm, Lumbricus terrestris: The search for TRP Channels
… growth. Allyl isothiocyanate, a prototypical TRPA1 agonist, has been used as an expellant for sampling earthworms, suggesting that earthworms possess TRPA1 channels. We began the search for TRPA1-like channels in earthworms using electrophysiological, immunohistochemical, behavioral and cell …
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MODULATION OF SYNAPTIC TRANSMISSION AT THE NUCLEUS TRACTUS SOLITARIUS
… nociceptive TRP channels TRPV1 (vanilloid) and TRPA1 (ankyrin) modulate synaptic transmission in the NTS. As a result of this modulation, the efferent functions that control autonomic and visceral functions will be regulated and account for the changes in autonomic neuropathy as patients with …
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Group III mGluR8 negatively modulates TRP channels
… mGluRs (mGluR8) and two TRP channels: TRPV1 and TRPA1. In the first study, we examined the interaction between group III mGluRs and TRPV1. Anatomical studies demonstrated that group III mGluR8 is expressed on cutaneous axons and is co-localized with TRPV1 in the dorsal root ganglia (DRG). In …
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Acrolein as a novel therapeutic target for spinal cord injury induced neuropathic pain
… transient receptor potential ankyrin 1 receptor (TRPA1) in DRG nociceptive neurons to transmit pain sensation. In addition, we have observed a significant increase of monocyte chemoattractant protein-1 (MCP1), a pro-inflammatory chemokine that is also known be increased upon acrolein stimulation …
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Sensory Transduction in Enteroendocrine Cells
… calcium studies of STC-1 cells, the TRPA1 agonists cinnamaldehyde and AITC evoked increases in intracellular calcium concentration that could be inhibited by the TRPA1 antagonist AP18. Calcium responses evoked by fatty acids, the bitter tastant denatonium and cold temperatures below …
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Distribution and function of TRP ion channels in primary sensory neurons
… raw garlic extract, allicin and DADS activate TRPA1 ion channels on primary sensory neurons in culture and nerve fibres in the vascular system. These findings highlight TRPA1 as a novel ion channel in the vascular system and provide novel pharmacological tools for investigating the role of this …
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Developing druggable in vitro models for investigating itch in atopic dermatitis
… AD lesional skin environment. It was found that TRPA1 and JAK1/2 inhibition reduced iPSCSN responses to the pruritogens thymic stromal lymphopoietin and interleukin-31, thus highlighting TRPA1 as a therapeutic target. In addition, other iPSCSN differentiation methods were explored and yielded …
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Regulation of Visceral Nociception by GPR35
… co-expression of GPR35 with noxious transducer TRPA1 in the nociceptive neuronal population of colonic DRG neurons. We showed that stimulation of TRPA1 vigorously excites colonic afferents, induces afferent mechanosensitivity and releases neuropeptide Substance-P (SP) from the colonic tissues, …
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Mechanisms of thermal sensitivity in rodent primary afferent neurons innervating the skin
… TRPV1 ion channel and cold sensitive TRPM8 and TRPA1 ion channels. However, the role of the TRPA1 receptor in cold transduction remains controversial. Cold sensitivity of primary afferents in adult rat was studied. Selective TRP channel agonists capsaicin, menthol, and mustard oil were then …
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Mechanisms and plasticity of cold sensitivity in peripheral neurons
… in sensory neurons, and two channels, TRPM8 and TRPA1, have been implicated in cold sensation. Ratiometric calcium imaging and quantitative rt-PCR studies revealed that cold sensitivity in sympathetic neurons and in a significant proportion of sensory neurons is independent of TRPM8 and TRPA1 …
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Nociception and the Experience of Pain Signaling Due to Nerve Damage
… include Transient Receptor Potential Ankyrin 1 (TRPA1), Transient Receptor Potential Melestatin 8 (TRPM8), and Cannabinoid Receptor 1 (CNR1). We hypothesize through knockdown of TRPA1, TRPM8, or CNR1 gene function may alleviate chronic pain-based behaviors and pain signaling. Gene manipulation by …
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Neuroinflammatory consequences of rhinovirus infection in the human airway
… of PNE with IL-1β for 24 hrs resulted in TRPA1 channel sensitivity in response to TRPA1 agonist, cinnamaldehyde. <br/><br/>We report for the first time the susceptibility of an airway neuronal model to RV infection. Findings confirm RV-A16 entry and replication in PNE, as well as a …
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