Global ETD Search
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Showing 1 to 5 of 5 for “"TRP120"”.
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Ehrlichia chaffeensis E3 Ligase TRP120 Ubiquitinates Tumor Suppressor FBW7 for Degradation to Promote Infection
… infection. The multifunctional E. chaffeensis TRP120 effector which has HECT E3 ubiquitin ligase activity, interacts with the host nuclear tumor suppressor F-BOX and WD domain repeating-containing 7 (FBW7). FBW7 is the substrate recognition subunit of the Skp1-cullin-1-FBOX E3 ubiquitin (Ub) …
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Eukaryotic protein mimicry as an infection strategy for Ehrlichia chaffeensis
Ehrlichia chaffeensis (E. ch.) expresses the TRP120 multifunctional effector on the surface of infectious dense-cored ehrlichiae which is known to play a role in phagocytic entry, but a cognate host receptor has not been identified. We recently reported that E. ch. activates canonical Wnt signaling …
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Ehrlichia chaffeensis Activates Notch Signaling Through SLiM Mimicry to Inhibit Apoptosis
… the E. chaffeensis tandem repeat effector, TRP120, has been shown to interact with host proteins important for activation and regulation of conserved signaling pathways including Wnt, Notch and Sonic Hedgehog. In this study, we investigated the molecular interactions and functional …
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Ehrlichia chaffeensis mediates Hedgehog and Hippo signaling to activate an anti-apoptotic cellular program
… In the past decade, tandem repeat protein TRP120 has emerged as a model moonlighting effector. Remarkably, TRP120 has been defined as a nucleomodulin, ligand mimic and ubiquitin ligase. Molecular mimicry is a survival strategy utilized by an array of pathogens to facilitate host-pathogen …
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TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
… (TRPs). The most well-characterized TRP, TRP120, uses multiple short linear motifs (SLiMs) to interact with host proteins and co-opt signaling axes to inhibit apoptosis. Interestingly, other ehrlichial TRPs have been shown to interact with a diverse array of host proteins and harbor …