Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"TRP ion channels"”.
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Distribution and function of TRP ion channels in primary sensory neurons
… and anti-inflammatory effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. The …
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Bioactive Lipids in Nociception
… drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a …
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Function of the forkhead gene fd3F in Drosophila chordotonal neuron differentiation
… internal stretch receptors required for coordination, balance and hearing. The outer dendritic segment of the Ch neuron is a compartmentalised motile cilium, a feature that is exclusive to this neuron subtype. Ch organs are specified early in development by expression of the proneural gene atonal …
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Molecular Determinants of TRP Channel Gating
<p>Transient Receptor Potential (TRP) ion channels are a family of proteins that contribute to a myriad of physiological functions. They have been extensively studied since their discovery 35 years ago; however, there are still many questions regarding the mechanisms by which they function. This …
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Mechanisms of thermal sensitivity in rodent primary afferent neurons innervating the skin
The role of temperature sensations elicited from the skin, include object identification, thermoregulation and the conscious perception of pain. Humans can differentiate at least three distinct cold sensations: innocuous cooling, cold pain and pain evoked by freezing. However, patients with painful …
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Funktionelle Interaktion von Polycystin 2 und TRPV4
… 1:400 bis 1:1000 betroffen. Dabei führen Mutationen im PKD1- oder PKD2 Gen zur Bildung multipler Zysten in den Nieren, was schließlich zur terminalen Niereninsuffizienz führt. Zu den extrarenalen Manifestationen der ADPKD gehören multiple Zysten in Leber und Pankreas, Kolondivertikel, …