Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"TRP channel"”.
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Molecular Determinants of TRP Channel Gating
<p>Transient Receptor Potential (TRP) ion channels are a family of proteins that contribute to a myriad of physiological functions. They have been extensively studied since their discovery 35 years ago; however, there are still many questions regarding the mechanisms by which they function. This …
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Gating Mechanisms of The Canonical Trp Channel Isoform Trpc4
<p>Non-selective cation channels formed by Transient Receptor Potential Canonical (TRPC) proteins play important roles in regulatory and pathophysiological processes. These channels are known to be activated downstream from phospholipase C (PLC) signaling. However, the mechanism by which the PLC …
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Genome-wide Association Study of TDI-Induced Asthma in a Korean Population : Signofocant Association of a T-catenin(CTNNA3) and TRP channel gene-gene interaction
… (multifactor dimensionality reduction)을 이용하였다. TRPM8의 rs10803666 의 연관성 분석이 유의한 것을 바탕으로 TRPM 가족과 TRPV 가족간의 상호작용을 분석한 후 TRP 채널 가족들의 상호작용을 알아보았다. 결과: CTNNA3 (alpha-T-catenin) alpha-3의 유전적 변이는 TDI 천식표현형에서 유의한 결과를 보였다 (5.84x10-6 for rs10762058, 1.41 x 10-5 for rs7088181, 2.03 x 10-5 for rs4378283). 두 …
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Eisenia hortensis Detects Chemesthetic Irritants through TRP Channels
… a common Transient Receptor Potential 1 (TRPA1) channel agonist, we hypothesized that earthworms possess TRPA1-like channels. We examined whether the earthworm Eisenia hortensis possesses TRPA1-like channels, as well as other TRP channel members. We assessed whether E. hortensis could …
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Role of Trp Channels In Mediating The Calcium Signaling Response of Brain Endothelial Cells to Mechanical Stretch
… was used to identify the calcium-permeable channels involved in the stretch-induced Ca<sup>2+</sup> influx. Antagonist of transient receptor potential (TRP) channel subfamilies, TRPC and TRPP, demonstrated a reduction of the stretch-induced Ca<sup>2+</sup> influx. RNA silencing directed at …
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Modulation of synaptic transmission by TRP channels
… sensory receptors, Transient Receptor Potential (TRP) channels, are expressed not only at peripheral terminals, but also at the central terminals of sensory neurons. While the role of these channels at the periphery is detecting environmental stimuli, their function at central terminals is not …
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Identifying Potential Agonists Of TRPA1 Using A Heterologous Expression System And Transgenic Mice
… many different receptor proteins, including TRP channels. TRPA1, a highly conserved TRP channel, is known to be activated by over ninety compounds. As TRPA1 is promiscuous in nature, it was considered a likely receptor for stimuli activating the trigeminal nerve. In this study, thirteen …
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Evaluation of the role of odontoblasts in dental pain
… studies have identified tentative links between TRP channels and dental pain, suggesting that TRP channels in dental nociceptive neurons may be directly activated by temperature changes and contribute to sensitivity to hot or cold foods. Certain structural and biochemical properties of …
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Role of transient receptor potential channels in mammalian oviduct and uterine epithelia
… cells is either via tight junctions or calcium channels, specifically, members of the transient receptor potential (TRP) channel superfamily and the Na+/Ca2+ exchanger. TRP channels are an important class of calcium channels with more than 28 identified members and their potential involvement in …
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Function and pharmacology of TRPM3 ion channel
For many ion channels there are few, if any, pharmacological agents, and even fewer showing specificity. In this study, a set of pharmacological tools were developed to investigate TRPM3, a widely expressed transient receptor potential (TRP) channel for which no functional role has yet been …
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Mechanisms and plasticity of cold sensitivity in peripheral neurons
… Members of the transient receptor potential (TRP) family of cation channels are currently recognised as the principal transducers of thermal stimuli in sensory neurons, and two channels, TRPM8 and TRPA1, have been implicated in cold sensation. Ratiometric calcium imaging and quantitative …
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Nociception and the Experience of Pain Signaling Due to Nerve Damage
… include Transient Receptor Potential Ankyrin 1 (TRPA1), Transient Receptor Potential Melestatin 8 (TRPM8), and Cannabinoid Receptor 1 (CNR1). We hypothesize through knockdown of TRPA1, TRPM8, or CNR1 gene function may alleviate chronic pain-based behaviors and pain signaling. Gene manipulation by …
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Genetic and molecular studies of cell-autonomous execution during programmed cell death in C. elegans
… of apoptosis. We found that the presumptive TRP channel CED-1 1 acts downstream of caspase activation in apoptotic cells to drive the increase in refractility. We discovered that CED-1 1 is also required for a decrease in cell volume and increase in nuclear permeability of apoptotic cells. We …
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Functional Characterization of the Mammalian TRPV4 Channel: Yeast Screen Reveals Gain-of-Function Mutations
Transient receptor potential (TRP) channels are a class of six-transmembrane (6-TM) cation-permeable channels that mediate flux of calcium and sodium into cells, leading to depolarization as well as activation of calcium-mediated second-messenger signaling pathways. The TRP channel family is large …
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The Role of the Scaffolding Protein INAD in Localization of Signaling Complexes to the Rhabdomeres of Drosophil Photoreceptors
… reaction that quickly opens Ca++-selective TRP channels. Subsequent Ca++ influx activates eye protein kinase C (ePKC), and calmodulin, which in turn modulate the activity of other visual proteins. Mutants in which the InaD / TRP association has been disrupted (inaD215) phenocopy the delayed …
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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
… <p>An abundance of research implicating TRP channels in rheumatoid arthritis synovial fibroblasts pathogenic phenotype has accumulated over the past decade. Studies of the rheumatoid synovium demonstrate the expression of several of these channels including TRPV1, TRPV2, TRPV4, TRPA1, …
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Investigating the role of TRPC3 in the biogenesis of extracellular vesicles
… the Ca2+ permeable transient receptor potential (TRP) channel TRPC3 may facilitate Ca2+-mediated EV biogenesis. TRPC3 contributes to the progression of ovarian cancer (OC) in vitro and in vivo, but its role in EV biogenesis and how this influences the pathogenesis of OC is unknown. This thesis …
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Mechanisms of Peripheral Sensitization in Inflammatory Knee Pain
… increased expression of the nociceptive ion channel transient receptor potential vanilloid 1 (TRPV1), possibly mediated by nerve growth factor, and systemic administration of a TRPV1 antagonist normalized digging behavior in mice. Interactions between non-neuronal cells and neurons are …
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Mechanisms of thermal sensitivity in rodent primary afferent neurons innervating the skin
… sensitive transient receptor potential (TRP) ion channels has given insights into the molecular mechanisms of thermal transduction. These include the heat sensitive TRPV1 ion channel and cold sensitive TRPM8 and TRPA1 ion channels. However, the role of the TRPA1 receptor in cold …
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Structural Studies of the Cold and Menthol Sensing Ion Channel TRPM8
… sensory circuit is mediated by receptors or ion channels expressed at peripheral nerve endings, which respond to specific chemical, thermal, or mechanical stimuli and trigger ion fluxes that lead to firing of action potentials for signal transduction. Understanding the mechanisms by which these …
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