Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"TRP Channels"”.
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Group III mGluR8 negatively modulates TRP channels
… this could occur through modulation of TRP channels on nociceptors. The following studies used a multifaceted approach to examine the interaction between group III mGluRs (mGluR8) and two TRP channels: TRPV1 and TRPA1. In the first study, we examined the interaction between group III …
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Modulation of synaptic transmission by TRP channels
… sensory receptors, Transient Receptor Potential (TRP) channels, are expressed not only at peripheral terminals, but also at the central terminals of sensory neurons. While the role of these channels at the periphery is detecting environmental stimuli, their function at central terminals is not …
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ATP, TRP channels and airway neuronal sensitisation
… roles of ATP and transient receptor potential (TRP) channels in chronic cough by working with primary bronchial epithelial cells (PBECS) and an in-Vitro human sensory neuronal model differentiated from human dental pulp stem cells termed peripheral neuronal equivalents (PNEs). TRP channels are …
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Eisenia hortensis Detects Chemesthetic Irritants through TRP Channels
… a common Transient Receptor Potential 1 (TRPA1) channel agonist, we hypothesized that earthworms possess TRPA1-like channels. We examined whether the earthworm Eisenia hortensis possesses TRPA1-like channels, as well as other TRP channel members. We assessed whether E. hortensis could …
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Role of Transient Receptor Potential (TRP) Channels in Nociception
Transient receptor potential (TRP) channels play an important role in sensory and nonsensory functions. TRPVanilloid 1 and TRPVanilloid 4 are proposed to be involved in inflammation-induced pain. TRPV1 is extensively studied and it is specifically involved in inflammatory thermal hypersensitivity. …
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Chemesthesis in the Earthworm, Lumbricus terrestris: The search for TRP Channels
… to irritation. Transient receptor potential channels play a major role in detecting chemesthetic stimuli and are found in a wide variety of organisms, from yeast to humans. Currently, there are no reports of TRP channels in earthworms. Earthworms, including Lumbricus terrestris, aerate and …
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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
… <p>An abundance of research implicating TRP channels in rheumatoid arthritis synovial fibroblasts pathogenic phenotype has accumulated over the past decade. Studies of the rheumatoid synovium demonstrate the expression of several of these channels including TRPV1, TRPV2, TRPV4, TRPA1, …
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Role of Trp Channels In Mediating The Calcium Signaling Response of Brain Endothelial Cells to Mechanical Stretch
… was used to identify the calcium-permeable channels involved in the stretch-induced Ca<sup>2+</sup> influx. Antagonist of transient receptor potential (TRP) channel subfamilies, TRPC and TRPP, demonstrated a reduction of the stretch-induced Ca<sup>2+</sup> influx. RNA silencing directed at …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i rise is proposed to mimic a physiological mechanism that influences early DP thymocyte selection and hence the T cell repertoire. During thymopoiesis, the patterning of [Ca2+]i plays a …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i rise is proposed to mimic a physiological mechanism that influences early DP thymocyte selection and hence the T cell repertoire. During thymopoiesis, the patterning of [Ca2+]i plays a …
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Evaluation of the role of odontoblasts in dental pain
… studies have identified tentative links between TRP channels and dental pain, suggesting that TRP channels in dental nociceptive neurons may be directly activated by temperature changes and contribute to sensitivity to hot or cold foods. Certain structural and biochemical properties of …
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Functional Characterization of the Mammalian TRPV4 Channel: Yeast Screen Reveals Gain-of-Function Mutations
Transient receptor potential (TRP) channels are a class of six-transmembrane (6-TM) cation-permeable channels that mediate flux of calcium and sodium into cells, leading to depolarization as well as activation of calcium-mediated second-messenger signaling pathways. The TRP channel family is large …
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Structural Studies of the Cold and Menthol Sensing Ion Channel TRPM8
… sensory circuit is mediated by receptors or ion channels expressed at peripheral nerve endings, which respond to specific chemical, thermal, or mechanical stimuli and trigger ion fluxes that lead to firing of action potentials for signal transduction. Understanding the mechanisms by which these …
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Assessing the Role of the Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channel in Visceral Sensation
… treatments. Transient receptor potential (TRP) channels represent a therapeutic target for abdominal pain that may have fewer side effects and potentially provide efficacious relief from pain. Various TRP channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin …
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The Role of the Scaffolding Protein INAD in Localization of Signaling Complexes to the Rhabdomeres of Drosophil Photoreceptors
… reaction that quickly opens Ca++-selective TRP channels. Subsequent Ca++ influx activates eye protein kinase C (ePKC), and calmodulin, which in turn modulate the activity of other visual proteins. Mutants in which the InaD / TRP association has been disrupted (inaD215) phenocopy the delayed …
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Pharmacological regulation and function of store-operated calcium channels
… all types of mammalian cell. STIM1, ORAI and TRPC have been regarded as the molecular basis of SOCE. Once the endoplasmic reticulum (ER) Ca²⁺ store is depleted, STIM1 proteins move to the plasma membrane and activate ORAI and TRPC channels to allow Ca²⁺ influx. In this thesis, the …
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MODULATION OF SYNAPTIC TRANSMISSION AT THE NUCLEUS TRACTUS SOLITARIUS
… (nAChRs) and transient receptor potential (TRP) channels can modulate excitatory/inhibitory neurotransmission. I have designed studies to understand the role of nAChRs and TRP channels in the modulation of neurotransmission in the cNTS. In the first aim, experiments were designed to test the …
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Identifying Potential Agonists Of TRPA1 Using A Heterologous Expression System And Transgenic Mice
… many different receptor proteins, including TRP channels. TRPA1, a highly conserved TRP channel, is known to be activated by over ninety compounds. As TRPA1 is promiscuous in nature, it was considered a likely receptor for stimuli activating the trigeminal nerve. In this study, thirteen …
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