Global ETD Search
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Showing 1 to 2 of 2 for “"TRMT1"”.
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The Role of tRNA methyltransferases in Cancer
… contribution of two tRNA methyltrans- ferases - TRMT1, responsible for catalysing the m2,2G modification at position 26 in tRNAs, and the METTL1/WDR4 complex, which catalyses the formation of m7G at position 46 in tRNAs - to cancer cell proliferation, stress responses, and adaptive mechanisms in …
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Characterisation of RNA modifications in human cancer cells
… of another TRMT RNA guanosine methyltransferase, TRMT1, in a human ovarian cancer cell line JHOC-5. TRMT1 is predicted to be an m2,2G and m2G methyltransferase in human cells. I found that its loss drastically diminished the level of m2,2G in small (<200nt) and large (>200nt) RNAs, but …