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Showing 1 to 2 of 2 for “"TRIM6"”.
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Proviral Roles of Ebola virus VP35 Ubiquitination
… we observed the host E3 ubiquitin ligase TRIM6 conjugates ubiquitin onto VP35 at lysine (K) 309. This post-translational modification was found to be proviral, but we did not know which VP35 role(s) ubiquitination regulated. We generated recombinant EBOVs encoding glycine (G) or arginine …
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
… K48-poly-Ub synthesized by the E3-Ub ligase TRIM6. These unanchored Ub chains promote the recruitment of RIG-I, which ultimately initiates the downstream production of IFN-I. This study establishes DHX16 as a PRR that partners with RIG-I for optimal activation of antiviral responses and …