Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"TRIM25"”.
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Non-Coding RNA Features Critical to the Replication of HIV-1
… from non-self RNA based on the CG composition. TRIM25 has previously been identified as a cofactor for two cytosolic RNA binding proteins that have antiviral functions, RIG-I where it is an essential cofactor, and ZAP where it functions as an enhancing cofactor. The mechanism by which TRIM25 …
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Mapping the cell cycle-dependent centrosomal interactome
… of three enriched interactors, AATF, PPP1CB, and TRIM25 was performed. Initial analysis on AATF revealed that this protein participates in the G1/S and G2/M transition when depleted using the auxin-inducible degradation system. Unfortunately contrary to the enrichment results, fluorescently tagged …
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Proviral Roles of Ebola virus VP35 Ubiquitination
… polymerase activity. Finally, we also found that TRIM25, TRIM6’s relative, facilitates ubiquitin ligation onto VP35 and enhances VP35’s non-covalent interaction with ubiquitin. EBOV replication is attenuated 100-10,000 fold in cells lacking TRIM25. Overall, our data support that TRIM6- and …
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Mechanism of Ubiquitin Induced Activation of RIG-I Like Receptors in Antiviral Innate Immunity
… in the immune system. A ubiquitin E3 ligase, TRIM25, promotes Lysine 63-linked polyubiquitination of RIG-I, and is essential for the RIG-I antiviral pathway. However, the biochemical mechanisms by which RIG-I is activated by ubiquitin remain poorly understood. In addition, whether …
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Molecular biology of segment 8 of the influenza A virus genome
… binding to RNA or a cellular ubiquitin ligase – TRIM25 – prevented induction of this re-localisation. This correlated with the inability of these NS1 mutant proteins to suppress phosphorylation of cellular interferon response factor 3. It was also found, using pull-down assays, that ADAR1 …