Global ETD Search
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Showing 1 to 9 of 9 for “"TRIM24"”.
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Trim24 In Normal & Malignant Hematopoiesis
… and known oncogene, we investigated <em>TRIM24</em> for putative relevance in AML. Expression data from previous studies have also suggested roles for <em>TRIM24</em> in chronic myeloid leukemia and acute lymphocytic leukemia; however, no studies to date have reported measurements of …
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Dissecting The Interaction Between P53 and Trim24
<p>Dissecting the Interaction of p53 and TRIM24</p> <p>Aundrietta DeVan Duncan</p> <p>Supervisory Professor, Michelle Barton, Ph.D.</p> <p>p53, the “guardian of the genome”, plays an important role in multiple biological processes including cell cycle, angiogenesis, DNA repair and apoptosis. …
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Trim24 As An Oncogene In The Mammary Gland
… a proto-oncogenic, transcriptional co-regulator, TRIM24, in mammary gland development and disease.</p> <p>We previously reported an unknown binding partner and negative regulator of p53, Tripartite Motif protein 24 (TRIM24). TRIM24 is a multifunctional protein, which acts as a co-regulator of …
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Trim24 Orchestrates Metabolic Reprogramming and Emt In Breast Cancer
… regulator Tripartite Motif Protein 24 (TRIM24) coupled with metabolic reprogramming and epithelial mesenchymal transition (EMT) in breast cancer. TRIM24 was first established by our laboratory as a previously unknown negative regulator of p53 via its RING domain, as a co-regulator of …
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Trim24 Promotes Mammary Tumor Development By Upregulating Metabolic Reducing Power
… Tripartite motif-containing protein 24 (TRIM24) is an E3 ligase for p53, a nuclear receptor co-regulator, and a histone reader. Over expression of TRIM24 correlates with poor overall survival of breast cancer patients. Previously, our lab created a mouse model that conditionally …
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Identification of Trim24 Domain Essentiality In Primary Trim24Coe Carcinosarcoma Cell Lines
… function of Tripartite motif protein 24 (TRIM24) through its H3K4me0 and H3K23ac dual histone signature reader function, its negative regulatory effect on the p53 tumor suppressor, in addition to its shown oncogenic driving capacity on immortalized mammary epithelial cells when …
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Genomewide Crispr/Cas9 Screen Identifies Network of Protein Complexes That Regulate Trim24
<p>TRIM24 is an oncogenic chromatin reader that is frequently overexpressed in human tumors and associated with poor prognosis. However, TRIM24 is rarely mutated, duplicated, or rearranged in cancer. This raises questions about how TRIM24 is regulated and whether changes in its regulation are …
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Dissecting The Roles of Trim24 In Regulation of Hepatic Lipid Metabolism and Inflammation
<p><strong>DISSECTING THE ROLES OF TRIM24 IN REGULATION OF HEPATIC LIPID</strong></p> <p><strong>METABOLISM AND INFLAMMATION</strong></p> <p>Lindsey Cauthen Minter, B.S., B.A.</p> <p>Advisory Professor: Michelle C. Barton, Ph.D.</p> <p>In this dissertation, I report the characterization of a new …
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Trim24-Regulated Estrogen Response Is Dependent On Specific Histone Modifications In Breast Cancer Cells
… this dissertation, I discovered that function of TRIM24 as a co-activator</p> <p>of ERα-mediated transcriptional activation is dependent on specific histone</p> <p>modifications in tumorigenic human breast cancer-derived MCF7 cells. In the first</p> <p>part, I proved that TRIM24-PHD finger domain, …