Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"TRIM21"”.
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Mechanisms of TRIM21-directed intracellular degradation
The cytosolic antibody receptor TRIM21 has been studied for more than a decade for its role in mediating antibody-dependent neutralization of nonenveloped viruses. The presence of antibodies in the cytosol is abnormal—by binding them and initiating inflammatory signaling cascades, TRIM21 acts as a …
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Structural Insights into TRIM21 Ubiquitination Mechanisms
… ubiquitination. The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. Understanding how TRIM21 functions as an E3 ligase mechanistically is required to explain …
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TRIM21 Mediated Antibody-Dependent Intracellular Immunity
… and receptor blocking. The discovery of TRIM21 as a cytosolic antibody receptor has revolutionised our understanding of humoral immunity and revealed that antibodies can mediate protective immunity inside cells. Recently, this TRIM21 mediated antiviral mechanism has been repurposed to …
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Rhinovirus neutralisation and the role of TRIM21
To be added
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Engineering the antibody-TRIM21 interface for the improved intracellular clearance of pathogenic targets
… Fc receptor and E3 ubiquitin ligase TRIM21, and that passive tau immunotherapy requires this pathway for in vivo efficacy. These findings indicate that enhancing antibody engagement with TRIM21 could substantially improve efficacy yet engineering strategies to optimise this …
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Selective Degradation of Aggregated Tau Protein Via Vectored Nanobody-TRIM21 RING Fusion Constructs
… Fc receptor and E3 ubiquitin ligase TRIM21. It was therefore hypothesised that intracellular aggregated tau could be targeted for degradation by exploiting this TRIM21 pathway. This thesis describes the development of TRIMinators, vectored constructs designed from the minimal antibody …
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Mechanisms underlying substrate engagement by TRIM7 and TRIM21 and strategies for re-directing their E3 ligase activity
… members of the TRIM protein family: TRIM7 and TRIM21. Both proteins are ubiquitin E3 ligases that ubiquitinate and degrade substrates. My work on TRIM7 has uncovered a unique molecular mechanism of substrate selection and explains why TRIM7 is reported to interact with unrelated and diverse …
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An investigation into the role of LUBAC and linear ubiquitin chains in antibody dependent intracellular neutralisation
… of antibody-bound viruses. It requires TRIM21, an Fc receptor and E3 ubiquitin ligase that resides in the cytosol. Binding of TRIM21 to the exposed Fc portion of an antibody that is bound to an internalised virus results in ubiquitin signalling and proteasomal degradation of the virus. …
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Analysen zu TRIM-Genen in Primaten
… aufweisen, während innerhalb des 11p15-Clusters TRIM21 und TRIM22 neben TRIM5a Anzeichen von positiver Selekion aufweisen. Insbesondere bei getrennten Analysen von Tripartite Motif und B30.2-Domäne konnte festgestellt werden, dass bei TRIM21 das Tripartite Motif leichte Anzeichen einer positiven …
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Determining the differences in effect of chromate, chromite and chromium picolinate in rainbow trout (Oncorhynchus mykiss) at environmentally relevant concentrations
… were also observed. These proteins were Trim21, Slc8a1, Myh4 and Myh6. For all, decreased abundance is associated with adverse outcomes. We hope that this study will advance knowledge on chromium toxicity in fish and protect all that inhabit the Ring of Fire region of Canada.
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IMPAIRMENT OF TOLL-LIKE RECEPTOR 9 AGONIST ANTI-TUMOR ACTIVITY BY ANTI-PD-1 ANTIBODY: ROLE OF MACROPHAGES
… anti-PD-1 ingegnerizzati. Il coinvolgimento del TRIM21 è stato valutato attraverso l’inibizione farmacologica ed esperimenti di silenziamento. Risultati: I topi che hanno ricevuto la combinazione CpG-ODN/anticorpo anti-PD-1 hanno mostrato un aumento della crescita tumorale e una marcata …