Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"TREM2"”.
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CD33 and TREM2 regulation of microglial functions
… receptor expressed on myeloid cells 2 (TREM2) are microglial receptors, variants of which affect Alzheimer’s disease (AD) risk, and therefore are potential targets for therapeutic intervention in AD. In this work, I show a conserved inhibitory role of CD33, a sialic acid-binding …
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Investigating the role of TREM2 and neuroinflammation in an experimental model of chronic cerebral hypoperfusion
… receptor expressed on myeloid cells 2 (TREM2) increase susceptibility to neurodegenerative conditions and dementia providing key evidence for the role of microglial dysfunction in dementia pathogenesis. Precisely how TREM2 dysfunction contributes to neurodegeneration and dementia remains …
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The novel phosphorylation site PLCγ2 Y1217 facilitates the TREM2 amyloid-β sensing pathway in microglia
… enriched within microglia and include *BIN1*, *TREM2*, *PLCG2* and *CLU*. The TREM2 R47H mutation carries the second highest genetic risk factor for LOAD and one allele increases risk of AD three-fold. TREM2 is an immunoreceptor expressed on microglia and detects anionic damage associated …
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Investigating the effects of TREM2, APOE and PILRα variants on microglial functions and neuronal loss
… on the roles of AD-risk associated variants of TREM2, APOE and PILRα in microglial functions and neuronal loss. Triggering receptor on myeloid cells 2 (TREM2) is an innate immune receptor, primarily expressed by microglia in the CNS and upregulated on the surface of microglia associated with …
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Identification of Functional Variants in Alzheimer's Disease-Associated Genes
… rare variants p.V232M in PLD3 and p.R47H in TREM2 significantly associated with AD risk. Additionally, genome-wide association studies (GWAS) uncovered common variants in ABCA7, BIN1, CD33, CD2AP, CLU, CR1, EPHA1, MS4A4A, and PICALM that contribute to AD; however, the most-significant …
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Immunomodulatory Roles of the Lysosomal Sialidase Neuraminidase 1
… CD68 as a substrate of Neu1 and showed that Trem2 homeostasis is altered in Neu1 KO microglia. In these cells, Trem2 is abnormally sequestered into endo-lysosomal vesicles, wherein sialylated Trem2 accumulates in lysosomes, promoting excessive proteolytic cleavage of the protein into soluble …
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Variaciones de la respuesta microglial según el contexto patológico en la Enfermedad de Alzheimer
… y un metabolismo oxidativo, mediado por TREM2. Este metabolismo aerobio es esencial para sustentar una activación microglial crónica, y se altera por una disminución de la disponibilidad de oxígeno o pérdida de función de TREM2. En modelos murinos, la hipoxia impide la activación …
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Neuroinflammation in Alzheimer’s Disease Mouse Brain Following Repetitive Mild Traumatic Brain Injury
… of the expression of specific receptors (e.g., TREM2) and neuronal loss can better illustrate the role of glial cells.</p>
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Investigating iPSC-Derived Macrophage Stimulation with Oxidised Low-Density Lipoprotein as an Effective In Vitro Model of Foam Cells in Atherosclerosis
… of M0, M1 and M2 polarisation states, however, *TREM2* was notably not differentially expressed in treated conditions. *TREM2* is commonly associated with foamy macrophages in vivo; this observation therefore highlighted that significant differences in expression profiles may preclude in vitro …
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Early Onset Alzheimer’s Disease Markers in Mouse Hippocampus Unveiled by Single-Cell Transcriptomic Analysis Following Cranial Radiotherapy
… markers such as CST3, APOE, APOE, APOJ/CLU, TREM2 and PIEZO1. We also identified downregulation of several ribosomal genes in pyramidal cells of the hippocampal CA1-3 regions in radiated mice. Comparisons between the observed transcriptional changes and markers of Alzheimer’s disease (PMID: …
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Investigation of the ABI3 protein in microglia and its association with Alzheimer’s disease in TgCRND8 mouse model
… patients. A cluster of these genes, including TREM2, PLCG2 and ABI3, are highly expressed in microglia and their exact function in these cells is poorly understood. Since microglial dysfunction is thought to play an important role in AD pathogenesis, this thesis was aimed at analysing the …
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Developing EasySci, a High-Throughput and Low-Cost Single-Cell Genomic Technique, to Study Aging and Alzheimer's Disease in Human and Mouse Brain
… the late-onset Alzheimer's disease model, APOE*4/Trem2*R47H, having cell population dynamics reminiscent of the 5xFAD early-onset model. This suggests the novel model's potential utility in Alzheimer's disease research. For instance, the expansion of septal nuclei neurons were observed in both …
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The Biological Basis of Heterogeneity in Parkinson's Disease - Insights from an Innate Immune Perspective.
… immune related genes and proteins (e.g. HLADR, TREM2, TLR2, TLR4, caspase-1) to PD and provided evidence that they may have a role in PD pathogenesis. Alpha-synuclein is central to PD, with evidence from neuropathology, genetics and animal/cell models indicating that it plays a significant …
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The role of Galectin-3 in the pathogenesis of Parkinson's Disease
… microglial basado en los marcadores TNFα, Trem2 y MerTK que podría ser específico en la EP. Este fenotipo se ve abolido en ausencia de Gal3, lo que pone de manifiesto la importancia de esta proteína en la activación microglial asociada a neurodegeneración. En definitiva, nuestro trabajo …
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Studying Microglia-Mediated Neurodegeneration Using Cocultures
… brain diseases, including Alzheimer’s, such as TREM2, CR3 and CSF1R. In this work, uPA and SYK were investigated further using assays for microglial survival, inflammation, and phagocytosis. Here, I found that uPA may influence inflammatory neurodegeneration, as well as microglial proliferation …