Global ETD Search
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Showing 1 to 3 of 3 for “"TREK-1"”.
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The splice variants of TREK-1 act as dominant-negative suppressors of human uterine relaxation: Implications for preterm labor
… cells from a resting state to one of excitation. TREK-1, a member of the K2P channel family, has previously been shown to exhibit elevated expression in pregnant human myometrium during gestation. In this study, three splice variants of intact human TREK-1 were identified in myometrium. For the …
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TREK-1 confers differential effects on contractile dynamics in myometrium and the oviduct, indicating a unique role in endometriosis and labor
… in contractility. It has been established that TREK-1, a potassium channel, plays a major role in quiescing the myometrium, which is essential for maintaining pregnancy. However, the effects of IL-6 and the role of TREK-1 in the fallopian tube have yet to be fully determined. We hypothesize that …
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Identification, Characterization and Function of Voltage-Gated and Two-Pore-Domain Potassium Channels in the Mouse Myometrium.
… the K2P potassium channel proteins, TASK-1 and TREK-1. These protein levels are dramatically reduced, although at different time points, throughout pregnancy. TREK-1 protein reductions occur within the first 7 days of gestation and remain at significantly reduced levels throughout gestation. …