Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"TRAMP"”.
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Tramp shipping
Thesis (B.S.) Massachusetts Institute of Technology. Dept. of Marine Transportation, 1947.
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Enhancing the Sustainability of Aluminium Production and Products
… investigates the influence of accumulative 'tramp elements' — unintended impurities such as Fe — in aluminium alloys, specfically their detrimental impact on material properties and processability. Understanding and mitigating the effects of tramp elements is critical to improving the quality …
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Identifying Subunit Organization and Function of The Nuclear Rna Exosome Machinery
… on a nuclear cofactor of the RNA exosome, the TRAMP complex. This complex is comprised of an RNA helicase and a poly(A) polymerase, as well as an RNA-binding subunit. However, it is currently unclear how the TRAMP complex is specifically assembled and moreover, if it is essential for life. The …
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Characterization of Mouse Prostate Tumor-Infiltrating Leukocytes
… but the results have been disappointing. The TRAMP model was used to evaluate specific interactions between an intact murine immune system and a prostate tumor that expressed a naturally processed weak tumor antigen. Vaccination trials for cancer patients have detected tumor-specific immune …
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Gene Therapy Using Tet-Repressor System to Modulate Prostate Tumor Microenvironment
… of <em>m</em>ouse <em>p</em>rostate (TRAMP) model to show that DCs infiltrating prostate tumors are phenotypically immature and using an in vitro assay we showed that TRAMPC2 cells but not granulocytes are the major inducers of this phenotype. We used a well-defined orthotopic prostate …
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Dietary interventions for reduction of prostate carcinogenesis in rodent models
… for the inhibition of PCa was evaluated in the TRAMP model of PCa. At 4 weeks of age, male TRAMP mice were randomized to consume: AIN-93G control, 10% TP, 2% SG or TP+SG for 14 weeks. Serum and testicular lycopene concentrations were significantly lower in TP+SG fed mice compared to mice fed TP …
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The Cellular and Molecular Properties of Flavinoids in Prostate Cancer Chemoprevention
… autochthonous murine model of prostate cancer (TRAMP). Mice were administered diets supplemented with 1% DHC, 1% fisetin or a combination of flavonoids (0.25% DHC, 0.25% fisetin, 0.25% quercetin, 0.25% luteolin) for 32 weeks. We demonstrated a significant reduction in genitourinary weight, and a …
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Inhibition des 26s Proteasoms : molekularer Mechanismus der Hyperthermie in Prostatakarzinomzellen?
… (A549) und murine PK-Zellen (TRAMP C1, TRAMP C2) wurden hyperthermiert (1 Stunde, 44 Grad C, +/- 20Gy, +/- Cycloheximid). Im zellulären Proteinextrakt wurde die chymotryptische 20s und 26s Proteasomenaktivität mit Hilfe eines fluorogenen Substrates bestimmt. Nach einer Stunde …
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Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
… transgenic adenocarcinoma of the mouse prostate (TRAMP) mice. Treatment of 6-week-old TRAMP mice with 100 mg/kg/day of OSU-CG5 via oral gavage for 4 weeks significantly reduced absolute and relative urogenital tract weights, as well as the weights of the individual lobes of the prostate. …
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Reducing the risk of prostate cancer with tomato and soy bioactives
… we designed a 10% TP diet intervention in TRAMP mice to determine the effects of consuming TP (post-puberty, ~5-6 weeks of age) during the process of carcinogenesis on PCa incidence. 8-week-old male C57BL/6 X FVB TRAMP mice were randomized to consume either an AIN-93G + 10% TP diet (N=90) …
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Overcoming dendritic cell-mediated suppression of T cell responses in a prostate tumor environment
… TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice. We demonstrated that both naive and effector tumor-reactive T cells are rapidly tolerized in the prostates and prostate draining lymph nodes (PDLN) of TRAMP mice, and that dendritic cells are important factors driving their …
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Impact of dietary tomato intake on prostate cancer throughout the course of disease development and progression in a transgenic mouse model
… adenocarcinoma of the mouse prostate; TRAMP), castrated to mimic ADT. In this chapter, we aimed to investigate the molecular underpinnings of individual CRPC tumors with the hypothesis that dietary tomato or lycopene supplementation impacted the expression of biomarkers associated with …
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The role of tomato and lycopene consumption on prostate carcinogenesis and prostate cancer treatment
… TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice were castrated at 12-13 weeks of age to model ADT, and the emergence of CRPC was monitored by ultrasound in two studies. In Study 1, TRAMP mice (n=80) were weaned onto an AIN-93G-based control diet (Con-L, n=28), a 10% TP diet (TP-L, 10% …
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Leaf litter ant communities in tropical lowland rain forests in Sabah, Malaysia
… rain forest. Additionally, an increase in tramp species was recorded with decreasing size of the forest fragments, leading to a very different community composition. Regarding the leaf litter ant community, the remaining rain forest fragments of Sabah are effectively isolated by a barrier …
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Charakterisierung von Leupaxin und seiner Interaktionspartner in Karzinomzellen
… welches das Wachstum von bestehenden TRAMP-Tumoren sowie von Fernmetastasen beschleunigt. Verschiedene Signalwege, die sich als LPXN-abhängig herausgestellt haben, geben Erklärungen für diese verstärkte Progression. Durch die Überexpression von LPXN in Prostatakarzinomzellen (PCa) ist …
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Development of prostrate cancer vaccine using PAP as target antigen
… was able to prevent and reduce the growth of TRAMP C1 prostate cancer cell-derived tumours in both prophylactic and therapeutic settings.
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Mechanisms of Cell Death Initiated in Herpes Simplex Virus Thymidine Kinase Expressing Colon Tumor Cells Treated with Ganciclovir and UCN-01
… the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Colon tumor cells treated with GCV arrest in S-phase, and cells treated with the combination of UCN-01 and GCV also undergo S-phase specific cell death. However, UCN-01 treatments induced the disappearance of key mitotic proteins and …
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The stirrings still of popular forms of entertainment in Samuel Beckett's first published play : examining the influences of the Music-Hall, Vaudeville, Circus and Early screen comedy on Waiting for Godot
… stage and stage-world; (c) the popular, "shifty" tramp-clown figure of stage and screen, and (d) the comic 'double-act' of the music-hall, vaudeville and circus--each of which serves to underline the bafflingly complex nature of human experience in a universe characterized by radical indeterminacy.
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Mark Twain's thought as revealed in his travel books.
… Brothers, Punch and Other Sketches (1878), A Tramp Abroad (1880), Life on the Mississippi (1883), Following the Equator (1897), and Europe and Elsewhere (1923). In these books Twain was not writing fiction; he was free of plot and characterization. Therefore his ideas were expressed …
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Towards sustainable material usage : time-dependent evaluation of upgrading technologies for recycling
… this problem through the accumulation of tramp elements in the material stream over time. Pertaining to the available operational and technological strategies that exist to mitigate accumulation, this thesis addresses the following questions: 1) How effective are these strategies at …
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