Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"TRAFs"”.
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Modeling rational agents with limited capability
… Region Adversarial Functional Subdifferential (TRAFS) algorithm for constrained optimization of unstructured nonsmooth convex Lipschitz functions. Unlike previous methods that assume a subgradient oracle model, I propose the functional subdifferential, defined as a set of subgradients that …
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Targeting Traf6 For Cancer Therapeutical Development
… factor (TNF)-Receptor Associated Factors (TRAFs) are a family of signal transducer proteins. TRAF6 is a unique member of this family in that it is involved in not only the TNF superfamily, but the toll-like receptor (TLR)/IL-1R (TIR) superfamily. The formation of the complex consisting of …
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Role of TRAF2/6 in tumour growth and bone metastases associated with breast cancer
… necrosis factor receptor associated factors (TRAFs) play a key role in signal transduction in mammalian cells. Several members of the TRAF family have been identified but only TRAF2 and TRAF6 are implicated in the regulation of both osteoclastic bone resorption and breast cancer. Here I …
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Determinants of protein-peptide interaction specificity in the Bcl-2 and TRAF families
… system, I explored the binding preferences of TRAFs 2, 3, and 5 to single and double mutant libraries of two peptide interaction partners from CD40 and TANK. Comparison of the enriched peptide sequences reveals a surprising degree of difference between these three close TRAF homologs, yielding …
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Identifizierung und Charakterisierung von Interaktionspartnern der Janus-Kinase Hopscotch in Drosophila melanogaster
… wurde. CG17033 ist ein Protein der TRAF-Familie. TRAFs sind Komponenten von Tumor-Nekrose-Faktor- oder Toll-Rezeptor Signaltransduktionskaskaden, welche die Aktivität von Transkriptionsfaktoren, z.B. humanem NF?B und Drosophila Dorsal steuern. Die Ergebnisse dieser Arbeit zeigen, dass ein …