Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"TRAF6"”.
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The Role of Traf6 Phosphorylation In Src/Traf6-Mediated Ikk, Jnk, Akt Activation and Tumorigenesis
<p>TRAF6 E3 ligase regulates numerous essential biological processes such as innate immune response, cell survival and osteoclast differentiation. Upon activation, it mediates activation of IKK/NF-κB and JNK signaling in response to engagement of toll-like receptor 4 (TLR4), interleukin-1 receptor …
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Targeting Traf6 For Cancer Therapeutical Development
… are a family of signal transducer proteins. TRAF6 is a unique member of this family in that it is involved in not only the TNF superfamily, but the toll-like receptor (TLR)/IL-1R (TIR) superfamily. The formation of the complex consisting of Receptor Activator of Nuclear Factor κ B (RANK), …
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Characterization of Hemocytes in Amblyomma americanum and Investigation of TRAF6’s Role in Proliferation of Hemocytes in Response to Infection
<p><em>Amblyomma americanum</em> is a medically important vector in the southeast United States. Cellular and molecular aspects of the immune system of this species were examined. To investigate cellular processes, hemocytes produced in response to gram-negative infection were characterized …
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Biochemical Mechanism of Protein Kinase Activation by the Ubiquitination System
… through activation of TAK1-IKK cascade by TRAF6 and Ubc13/Uev1A in a polyubiquitinationdependent manner. Mechanistically how TAK1 is activated by the TRAF6- Ubc13/Uev1A dependent polyubiquitination system is unknown. Whether TAK1 and IKK kinases can be activated by other than …
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Isolation of innate immune response genes, expression analysis, polymorphism identification and development of genetic markers for linkage analysis in common carp (Cyprinus carpio)
… TLR7b, TLR9, TLR21, TLR22, MyD88a, MyD88b, TRAF6a, TRAF6b, type I IFN, IL-1β, IL10a and IL10b. Putative SNPs were genotyped in a SNP discovery panel consisting of different common carp strains and koi to evaluate their allele frequencies and in a full-sib family to validate their segregation …
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Identifizierung von Signaltransduktionskomponenten des Latenten Membranproteins 1 des Epstein-Barr Virus
… Im ersten Teil der vorliegenden Arbeit konnte TRAF6 als essentielles und spezifisches Signalmolekül für die Induktion von p38 MAPK durch LMP1 auf einem MKK6-abhängigen Signalweg identifiziert werden. In TRAF6 defizienten Maus-Fibroblasten ist eine signifikante p38 MAPK-Aktivierung durch LMP1 …
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Mechanisms of TRAF Signaling
… molecules. The roles of TRAF1, TRAF2, and TRAF6 are investigated structurally and functionally in the activation of NF-κB, AP-1, and Src-family kinases. Cbl proteins are identified as positive and negative regulators of Src-family kinase signaling. The molecular structure of TRAF6 is …
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Role of TRAF2/6 in tumour growth and bone metastases associated with breast cancer
… family have been identified but only TRAF2 and TRAF6 are implicated in the regulation of both osteoclastic bone resorption and breast cancer. Here I studied the role of TRAF2 and TRAF6 in breast cancer induced osteoclastogenesis and osteolysis. I observed that TRAF2, but not TRAF6, is highly …
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Investigating the regulation and enzymatic function of human ecsit in innate immune signalling.
… pathways. ECSIT was initially described as a TRAF6 interacting protein that bridged the TLR signalling intermediate TRAF6 to MEKK1 and downstream activation of NFκB. Subsequent data revealed an important developmental role for ECSIT in the BMP signalling pathway based on the embryonic lethal …
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Role Of Crebh In Endotoxin Mediated Modulation Of Hepatic Metabolism
… CREBH and TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase that plays a key role in mediating TLR signaling. While LPS-induced TRAF6-CREBH interaction relies on MyD88, TRAF6 mediates the ubiquitination of CREBH to facilitate CREBH activation upon LPS challenge. Functionally, …
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Deciphering The C-Type Lectin Receptor Signaling Pathway In Macrophages In Response to Candida Albicans
… anti-fungal immune response<em>. </em>TAK1 and TRAF6 are critical nodes in NF-κB and MAPK activation downstream of immune surveillance and may be critical to the signaling cascade initiated by C-type lectin receptors in response to <em>C.</em> <em>albicans</em>. Macrophages derived from both …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
… including the TNF receptor associated factor 6 (TRAF6) E3 ubiquitin ligase - to produce cellular responses such as apoptosis, survival, and inhibition of neurite outgrowth. Recently,p75NTR was also shown to undergo γ-secretase-mediated regulated intramembrane proteolysis, and the receptor ICD was …
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Transcriptome Analysis of Sea Lamprey Embryogenesis
… (protein kinase), SMAD2 (signal transducer), TRAF6 (signal transducer), PCNA (DNA replication), SLX4 (endonuclease), and PXN (focal adhesion) were selected for their NGS expression levels, GO annotations, and biological function significance. Their NGS expression levels were verified using …
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Defining the Physiological and Molecular Role of Pellino3 in TLR3 Signalling
… Pellino3 expression which in turn interacts with TRAF6 and facilitates its polyubiquitination. This modification of TRAF6 suppresses its ability to bind and ubiquitinate a key anti-viral transcription factor IRF7, thereby down regulating the type 1 IFN response. The findings outlined in this …
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The Role of K63-Linked Ubiquitination Cycles In Akt Kinase Activation
… non-proteolytic K63-linked ubiquitination by TRAF6 ubiquitin E3 ligase. This modification on Akt was required for membrane recruitment, phosphorylation and activation of Akt in response to growth factor stimulation. The human cancer-associated Akt E17K mutant exhibited an increase in …
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Characterisation of the role of human Evolutionary Conserved Signalling Intermediate in Toll (ECSIT) in Mitogen Activated Protein Kinase (MAPK) signalling
… orginally as a TNF receptor associated factor 6 (TRAF6) interacting partner. The murine homolog mECSIT has been shown to be involved in NFκB, MAPK, BMP and mitochondrial signalling. To date there is no work published on the human homolog, hECSIT. In this thesis, I present data indicating that …
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Role of Mir-19A Released By Inflammatory Breast Cancer Cells In The Regulation of Dendritic Cell Functions: In Vitro Model of Crosstalk In The Tumor Microenvironment of Inflammatory Breast Cancer
… SOCS-1 and the miR-146a target genes IRAK1, TRAF6. PTEN, SOCS-1 and IRAK1, TRAF6 are important negative and positive regulator of cytokine- and TLR-mediated activation/maturation signaling pathway in DCs.</p> <p>Increased levels of IL-6 induced the upregulation of miR-19a synthesis in SUM-149 …
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Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets
… on the interaction of the E3 ubiquitin ligase TRAF6 with IRAK2 and IRAK3.<br/><br/>I discovered that the kinase domain of IRAK2 is monomeric in solution, while IRAK3 is in a concentration-dependent equilibrium of monomeric and dimeric states. ATP-binding assays revealed that IRAK2 binds ATP in …
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Modulation of host NF-[k̳̳a̳p̳p̳a̳]B pathway by the Toxoplasma gondii secreted factor, GRA15
… and transcriptional regulation in an IKK- and TRAF6-dependent manner. We additionally show that GRA 15 may complex with TRAF3. Some Toxoplasma strains activate the host NF-[kappa]B pathway much more than others. A combination of factors, including differences in expression and sequence of GRA …
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