Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"TRAF2"”.
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Role of TRAF2/6 in tumour growth and bone metastases associated with breast cancer
… of the TRAF family have been identified but only TRAF2 and TRAF6 are implicated in the regulation of both osteoclastic bone resorption and breast cancer. Here I studied the role of TRAF2 and TRAF6 in breast cancer induced osteoclastogenesis and osteolysis. I observed that TRAF2, but not TRAF6, is …
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Mechanisms of TRAF Signaling
… adaptor molecules. The roles of TRAF1, TRAF2, and TRAF6 are investigated structurally and functionally in the activation of NF-κB, AP-1, and Src-family kinases. Cbl proteins are identified as positive and negative regulators of Src-family kinase signaling. The molecular structure of …
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TRAF Regulation of Caspase-2-Dependent Apoptosis in Response to DNA Damage
… dimerized caspase-2, which in turn identified TRAF2 as a direct activator of caspase-2. Specifically, we utilized the Bimolecular Fluorescence Complementation technique, wherein complementary halves of the Venus fluorophore are fused to caspase-2: when caspase-2 dimerizes, the non-fluorescent …
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Biochemical and Genetic Studies on CC2D1A, a new NF-κB Activator and a Regulator of Synaptic Functions
… enzyme UBC13, a RING domain ubiquitin ligase TRAF2, a protein kinase TAK1, and an essential regulator of IKK complex, NEMO. CYLD, a deubiquitination enzyme specific for Lysine-63 linked polyubiquitin chains, negatively regulates the activity of CC2D1A. These results suggest that CC2D1A …
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Identifizierung von Signaltransduktionskomponenten des Latenten Membranproteins 1 des Epstein-Barr Virus
… Onkogens, das unterhalb von TRADD und TRAF2 agiert. Im zweiten Teil meiner Arbeit konnte JNK2 als eine weitere, durch LMP1 induzierte MAPK in B-Zellen identifiziert werden. Im Zuge dieser Arbeit wurden dominant-negative Mutanten von JNK1 und JNK2 hergestellt, deren Expression eine …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… are identified. Also, the involvement ofTRAF2, FADD, caspase-8, caspase-10 and RIP1 in JNK activation were examined. It was found that JNK is activated in HCT116, but not in DR5, caspase-8 and FADD knockdown cells after 5-FU treatment. Moreover, the absence of caspase-10, TRAF2 and RIP1 …
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The non-canonical NF-kappaB pathway as a novel player in beta cell dysfunction in diabetes
… mouse model of constitutive NIK activation. The TRAF2/TRAF3/BIRC2/3 E3 ubiquitin ligase complex tightly controls activation of NIK. Deletion of either component (βTRAF or βBIRC) promotes β cell-intrinsic NIK activation. βTRAF2 mice showed exacerbated glucose intolerance and impaired first-phase …
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The role of sphingosine kinases and dihydroceramide desaturase in regulating senescence in prostate cancer cells
… which binds to proteins such as HDAC1/2 and TRAF2 to elicit cell responses. Recently, other mediators in the pathway have also emerged as important mediators of autophagic, apoptotic, senescent and proliferative cell processes.This study aims to investigate the molecular pathways which link …
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Regulation des Zelloberflächenmoleküls CD83 durch das Epstein-Barr Virus und Analyse seiner Funktion
… which are mutated in the binding regions for TRAF2 (CTAR1) or TRADD (CTAR2) are not able to transactivate the CD83 promoter. By co-transfection of LMP1 and dominant/negative IκB the CD83 promoter could not be activated because of inactivation of NF-κB. These experiments clearly demonstrate …