Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"TR-FRET"”.
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STRUCTURAL INSIGHTS INTO POLYUBIQUITIN CHAIN FORMATION MEDIATED BY NEDD4 HECT LIGASE
… of HECT E3 ubiquitin ligases which regulates the trafficking and stability of receptors and signaling proteins. Precise spatiotemporal control of its activity is essential for orchestrating cellular functions. In resting condition, NEDD4 N-terminus by interacting with its C-terminal HECT catalytic …
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Examining the Role of Phospholamban Phosphorylation on Interaction with SERCA Using Fluorescence Microscopy
… role in normal cardiomyocyte function through controlling the speed and extent of myocyte relaxation. The interaction between PLB and SERCA is altered in many forms of heart failure (HF), making these proteins potential targets for the treatment of HF. Both proteins have been extensively studied …
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Microfluidic Approaches for Investigating Aggregated Forms of Disease-Related Proteins
… difficult to analyse due to their low abundance, transient nature and heterogeneity in their structure. In fact, prions, known to be associated with transmissible spongiform encephalopathies, have not yet been fully characterised as parts of the prion composition seem to lose infectivity through …
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Thermodynamics and Kinetics of Iso-1-cytochrome c Denatured State
… how proteins fold have focused on the transition state rather than the earliest folding events. We study these initial events using the assumption that protein folding must involve the formation of the most primitive structure possible – a simple loop. Our laboratory has developed a …
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Thermodynamics and Kinetics of Iso-1-cytochrome c Denatured State
… how proteins fold have focused on the transition state rather than the earliest folding events. We study these initial events using the assumption that protein folding must involve the formation of the most primitive structure possible – a simple loop. Our laboratory has developed a …
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Discovery of macrocyclic inhibitors of challenging protein-protein interactions
… acids building blocks. While the machine is constructed to use 96-well plates, I found a 384-well filter plate which could be installed in the same machine with minor modifications. Furthermore, instead of storing amino acids in 50 mL tubes as designed, a new amino acid holder was constructed to …