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Showing 1 to 2 of 2 for “"TPK1"”.
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Prediction and Investigation of Novel Proteins in DNA Double Stranded Break Repair
… efficiency. We further investigated the roles of Tpk1, Arp6 and Psk1/Psk2 in NHEJ repair. Deletion of TPK1, ARP6, PSK1 and PSK2 reduced efficiency of repair in chromosomal and plasmid based assays and showed sensitivity to different DNA damaging agents. We suggest that Tpk1, catalytic subunit of …
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The Role of Nutrient Availability in Therapeutic Response of Leukemia
… revealed thiamine pyrophosphate kinase 1 (TPK1), which converts vitamin B1 (thiamine) into the cofactor thiamine pyrophosphate (TPP), as a metabolic dependency under ASNase treatment. In glutamine-anaplerotic leukemia cells, we found that TPP availability enables asparagine synthesis from …