Global ETD Search
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Showing 1 to 11 of 11 for “"TPGS"”.
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Cell Toxicology Study of RRR-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS).
… polyethylene glycol 1000 succinate (TPGS) in transformed and cancerous cell lines. We used RAW264.7 macrophage and prostate cancer (LNCaP) cell lines in this study. TPGS caused cell death and decreased cell viability in a dose and time dependent manner. Cell death was evaluated …
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Cell Toxicity and Uptake of RRR-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) by Various Cell ines <em>In Vitro</em>.
… polyethylene glycol succinate (TPGS, with that of alpha-tocopheryl succinate (α-TS). Both TPGS and α-TS are water-soluble forms of vitamin E with important clinical applications. Cytotoxicity assays with RAW 264.7 and LNCaP cells incubated overnight with TPGS or α-TS at …
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Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
… for topical drug delivery. We utilized vitamin E TPGS polymer to develop nanomicelles to solubilize the drugs. The polymer was also modified with PEG chain having molecular weight of 2000. Synthesis of modified polymer was performed and confirmed by NMR studies. Critical micelle concentration of …
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Design of Thermosensitive Hydrogel for Extended-Release of Praziquantel
… them was the formulation consisting of PEG-DSPE/TPGS mixed micelles-poloxamer 407 hydrogel hybrid system; another was the poloxamer 407 hydrogel adding with HPMC as an adhesive. These hydrogel formulations had a reversible sol-gel transition property at approximate 26 °C and obtained high loading …
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Enhanced Etoposide Solubility and Anticancer Activity using Complexation and Nanotechnology
… polyethylene glycol 1000 succinate (Vitamin E TPGS ) and solvent evaporation thin-film rehydration technique. All resulting formulations are thoroughly physico-chemically characterized with FT-IR/ 1H-NMR spectroscopies, powder X-Ray Diffraction, and Scanning electron microscopy (SEM). Liquid …
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Co-encapsulation of anti-breast cancer drugs in nanoparticles reduce antagonism
… polyethylene glycol succinate nanoparticles (PLA-TPGS NPs), drug antagonism was significantly reduced versus its free unprotected form, and this effect attenuated at high drug concentrations. The fluorescent model drug coumarin 6 encapsulated in nanoparticles, exhibited enhanced cellular uptake …
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Novel nanocarriers to improve drug delivery for age-related macular degeneration
… 40 (HCO-40), Octoxynol-40 (OC-40) and Vitamin E TPGS as potential delivery cargos to treat AMD. Lipophilic drugs such as etodolac (ETD), oxaprozin (OXP) and indomethacin (IN) were successfully encapsulated in the hydrophobic core of the nanomicelles with enhanced solubility. Nanomicellar …
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Preparation and Evaluation of Cefuroxime Axetil Gastro-Retentive Floating Drug Delivery System for Improved Delivery via Hot-Melt Extrusion Technology
… that CA was highly soluble in Kolliphor® TPGS and Gelucire® 44/14, and solubility increased linearly as the concentration increased. All the extruded granules shofloating lag time of less than 5 seconds and floated for more than 12 h simulated gastric fluid. Optimized formulation was able …
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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
… hydrogenated castor oil – 40 (HCO-40) and Vit. E TPGS) are known to generate nanomicellar constructs with hydrophobic core and hydrophilic corona. However, constructs prepared from a single polymer are unstable and easily fall apart at high temperature. Inclusion of a second polymer such as Oc-40 …
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Advancements in green chemistry approaches to chemical synthesis
… part. For instance, in vitamin E derived TPGS-750-M by Lipshutz's group and L-proline based PS- 750-M from Handa's group, polyethylene glycol moiety as a hydrophilic part may not be biodegradable. Therefore, a second-generation PS-750-M (2nd Gen-PS) is developed as an alternative of …
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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
… nanomicelles contained HA-ss-PLGA and Vitamin E TPGS amphiphilic polymers. Addition of RTV can inhibit P-gp and CYP3A4 mediated metabolism of PTX, thus increasing the intracellular levels of the chemotherapeutic drug. This can help in reversing MDR and sensitizing the cells towards PTX. In the …