Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"TPEN"”.
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I-Kinetic And Mechanistic Investigations Of Amino Acid Substrates Reactivities With Ferryl Species
… AND CHARACTERIZATION OF DERIVATIVES OF THE BN-TPEN LIGAND AND THEIR METAL COMPLEXES</p> <p>by</p> <p>AHMED IBRAHIM YOUSSEF ABOUELATTA</p> <p>MAY 2011</p> <p>Advisor: Dr. Jeremy Jacob Kodanko</p> <p>Major: Chemistry (Organic)</p> <p>Degree: Doctor of philosophy</p> <p>The reactivity of …
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Investigating Potential Therapies to Decrease the Rate of Cystine Stone Growth in Slc3a1-/- Mice
… methyl selenocysteine, homocysteine, tiopronin, TPEN and a zinc-supplemented diet– were also examined for their efficacy in reducing the rate of cystine stone growth. µCT analysis revealed stone growth proceeds linearly. Sulforaphane and TPEN supplementation resulted in a reduced rate of stone …
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Genomic analysis in human solid tumours:Copper Homeostasis Genes in Colorectal cancer
… (2- pyridylmethyl)ethylenediamine (TPEN) in two human colorectal cancer cell lines (Caco-2 and HT29). Moreover, the Atox1 silencing has enhanced the toxic effects of copper-ClHQ complexes and TPEN in Caco-2 cells confirming that the inhibition of copper chaperone Atox1 could be a …
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Developing Analytical Tools to Study Copper Homeostasis in Biological Systems
… of high-affinity Cu(I) ligands and to visualize TPEN-induced changes of Cu(I) levels in live mouse fibroblasts by two-photon excitation microscopy using the emission-ratiometric Cu(I) probe crisp-17. Altogether, these studies revealed that mammalian cells maintain a dynamic yet tightly controlled …
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Mesures des concentrations totales en calcium et en zinc au niveau de tissus biologiques (cerveau et muscles squelettiques)
… BAPTA essentiellement grâce à l’introduction du TPEN, chélateur présentant une grande affinité pour le Zn2+ comparativement au Ca2+. Nous nous sommes ensuite intéressés à l’application de la méthode nouvellement développée à des régions spécifiques du cerveau impliquées dans plusieurs pathologies …
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Studies on the role of zinc in maintaining antioxidant status in the heart.
… In contrast, in vitro acute Zn2+ depletion with TPEN reduced Cu/Zn-SOD activity, but not GSH content. Neither method of Zn2+ depletion had any effect on either myocardial Zn2+ content or Caspase 3 activity, but plasma levels of Zn2+ were reduced following dietary Zn2+ depletion. These results …