Global ETD Search
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Showing 1 to 3 of 3 for “"TPC2"”.
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Identification of the TPC2 interactome reveals TSPAN10 and OCA7 as key players in the biogenesis of melanosomes
… the melanosome localized cation channel, TPC2, genetically fused with the BioID2 biotin ligase, to identify proteins in proximity to TPC2 at the cytosolic surface of melanosome membranes of MNT1 melanoma cells. Through mass spectrometry analysis of biotinylated proteins enriched through …
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Interactions between Human Two-pore Channels and Nonaspanin Proteins
… all TM9SF family, only TM9SF1 interacts with TPC2 structurally, which suggests that there might be functional interaction between TM9SF1 and TPC2. Indeed, my results showed that TM9SF1 increases LC3-II/LC3-I ratio in TPCs knockdown groups significantly compared with groups without TPCs …
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Ionic Mechanism of Lysosomal Function and Cell Metabolism
… to the lysosomes and deletion of either TPC1 or TPC2 leads to delayed clearance of autophagosomes, resulting in enlarged lysosomes and accumulated contents inside the lysosomes. Cells with both TPC deleted also exhibit 50% reduction in lysosomal amino acids under normal culture conditions, …