Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 180 for “"TPA"”.
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Synthesis and expression of the Erythrina trypsin/tissue plasminogen activator (tPA) inhibitor encoding-gene : genetic dissection to correlate the interaction of Erythrina and Soybean trypsin inhibitors with tPA
… chymotrypsin and tissue plasminogen activator (tPA). ETI was previously sequenced and its crystal structure determined from which it could be seen that ETI has good homology to soybean trypsin inhibitor (STI). However, STI does not inhibit tPA. From the three-dimensional structure of ETI it was …
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Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model
Intravenous tissue-type plasminogen activator (tPA) is recognized as the standard treatment for ischemic stroke. However, its narrow therapeutic window and association with an increased risk of intracranial hemorrhage have required caution when used. In this context, several approaches are required …
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Viral jun oncogene serves as a suppressor of phorbol ester TPA induced tumor cell invasion and stromelysin gene expression
… ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was suppressed. This phenomenon could partially be explained by the suppression of the induction by phorbol ester of expression of the metalloproteinase, stromelysin (transin). Of interest was the finding that TPA induction of other cellular …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
… with 12-O-tetradecanoylphorbol-13-acetate (TPA), old cell morphology starts to change young cell like in addition to molecular markers of cellular senescence, such as increases of DNA synthesis, pRB hyperphosphorylation, reductions of p53, p21Sdi1/WAF1/CIP1 and SA-β-galactosidase activity. …
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Novel Roles for the Tissue Plasminogen Activator System in the Development of Fetal Alcohol Syndrome and the Regulation of Contextual Learning After Stress
… (FAS). Since tissue plasminogen activator (tPA) has been implicated in mediating excitotoxic neurodegeneration we subjected neonatal WT and tPA<sup>-/-</sup> to an acute ethanol paradigm that serves as a model of FAS. We observed persistent upregulation of tPA and extensive neurodegeneration …
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The Role of Effective Grievance Management Procedures in Enhancing the Work Performance
… and secondary data have been collected from TPA- Mtwara Port and OLAM (T) LTD - Mtwara Branch. The primary data have been collected through three methods which were questionnaires, observation method and interview method. These include descriptive statistics which has been further analyzed …
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Emotional responsivity in people high and low in trait positive affect
… who report high levels of Trait Positive Affect (TPA) experience better mental and physical health outcomes than individuals low in TPA. The current study examined emotional responsivity in forty-five undergraduates who scored either high or low in trait positive affect. Participants' reactions to …
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Stimulus-secretion coupling in the exocrine pancreas of the rat: Interactions between secretagogues
… in Ca 2 mobilisation. 3. The phorbol ester TPA (12-0-tetradecanoyl phorbol-l3-acetate) alone induced 3 H-protein release from permeabilised pancreatic acini but when combined with ACh a synergistic secretory response resulted at an intracellular free [Ca 2+]i = 10 4M. Lowering intracellular …
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Proteolytic mechanisms involved in the metastasis of human melanoma cells
… activation by tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) is one such mechanism. Extensive reports in the literature (reviewed in the introduction) indicate that most tumour cells synthesize uPA and that it is this enzyme, particularly when receptor-bound, …
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Protein kinase C modulates mitogenic signalling by epidermal growth factor in T51B rat liver cells.
… to 24 hours. The tumour promoting phorbol ester, TPA, which is known to activate PKC, is not mitogenic to T51B cells. TPA modulates the responses of EGF or, serum depending upon the culture conditions. When TPA is added to serum-deprived cells in the presence of EGF or serum, it potentiates DNA …
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A Quantitative Investigation of Selected Reactions in the Fibrinolytic Cascade
… the rate of tissue type plasminogen activator (tPA) inhibition by plasminogen activator inhibitor type 1 (PAI-1) was investigated using a previously devised end point assay. HMW-FDPs decreased the k2 for tPA inhibition rate by 3-fold. Thus, HMW-FDPs protect tPA from PAI-1. TAFIa treatment of the …
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Software orchestration of instruction level parallelism on tiled processor architectures
… frequencies. A tiled processor architecture (TPA) eliminates long wires from its design by distributing its resources over a pipelined interconnect. By exposing the spatial distribution of these resources to the compiler, a TPA allows the compiler to optimize for locality, thus minimizing the …
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Reactivity of rhodium-heteroatom bonds: from catalytic bond activation to new strategies for olefin functionalization
… or[C1Rh(cod)]2. The 2-rhodaoxetane [(TPA)Rhmec2_,-4u, 0-2-oxyethypr BPh4- (TPA = tris[(2-pyridal)methyl]amine) was investigated for its potential as an intermediate in proposed functionalization reactions of olefins. RTPA)Rh111(K2-C,0-2-oxyethyl)]+ BPh4- was prepared by two published …
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Fast transfer path analysis using controlled electric motors as in-situ blocked force vibration sources
… methodologies such as Transfer Path Analysis (TPA) are used to analyse noise and vibration propagation in complex systems. In response to the evolving demands in acoustic engineering, TPA approaches have been continuously improved to provide reliable diagnostic information, simplify the …
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Roles of protein kinase C in cell death and breast cancer
… paclitaxel treatment. Upon PKC activation with TPA the PKCδ-Smac complex was stabilized and the paclitaxel-mediated dissociation and death was suppressed. The decreased cell death could potentially be caused by a competition between PKCδ and XIAP for Smac binding. We also show that activation of …
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Charakterisierung von Taps, einer neuen Aspartylprotease in der Differenzierung und Homöostase komplexer Epithelien
… der Rückenhaut der Maus durch den Tumorpromotor TPA und somit in entzündlicher und hyperplastischer Haut stark induziert wird, wurde eine neue Aspartylprotease (Taps = TPA-inducible aspartic proteinase-like gene in skin) entdeckt. In einer detaillierten Analyse von Mausgeweben konnte nachgewiesen …
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PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles
… for the tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA) and their inhibitor PAI-1 was measured in granulosa cells. uPA and PAI-1 mRNAs peaked 12 hours and 36 hours after hCG administration respectively. tPA mRNA decreased 36 hours after hCG. Celecoxib …
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