Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 151 for “"TP53"”.
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Cooperative Genomic Events Driving Mutant TP53-Driven DCIS Progression
… of human DCIS and breast cancer suggest that <em>TP53</em> mutations occur early in DCIS, suggesting a critical role for mutant <em>TP53</em> in driving disease progression. Using a somatic mouse model of <em>p53<sup>R245W</sup></em> induced breast cancer (equivalent to the …
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Tp53 As A Biomarker In Head and Neck Squamous Cell Carcinoma
… Several retrospective studies have evaluated TP53 in HNSCC, and results have suggested that specific mutations are associated with poor outcome. However, there exists heterogeneity among these studies in the site and stage of disease of the patients reviewed, the treatments rendered, and …
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The detection and clinical significance of TP53 dysfunction in chronic lymphocytic leukaemia.
… p53. Loss of the chromosome containing the gene TP53, which encodes the protein p53 and/or mutation of the gene, occurs in approximately 5-10% of newly diagnosed CLL patients. This rises to over 30% in patients who relapse after therapy. In addition another important protein within the DNA damage …
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Identification and Characterization of De Novo Germline Tp53 Mutation Carriers In Families With Li-Fraumeni Syndrome
… syndrome caused by a deleterious mutation in TP53. An estimated 48% of LFS patients present due to a de novo mutation (DNM) in TP53. The knowledge of DNM status, DNM or familial mutation (FM), of an LFS patient requires genetic testing of both parents which is often inaccessible, making de …
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Evaluation of Current Clinical Criteria For Li-Fraumeni Syndrome In A Diverse Sample of Tp53 Mutation Carriers
… by heterozyogous germline mutations in the <em>TP53 </em>gene and characterized by an excess of early-onset cancers, high lifetime risk of cancer, and a wide range of tumor types. Recent studies suggesting a benefit in comprehensive screening protocols for both children and adults make the …
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Germline Mutation Detection In Next Generation Sequencing Data and Tp53 Mutation Carrier Probability Estimation For Li-Fraumeni Syndrome
… data analysis, we also use it to estimate the TP53 mutation carrier probability for Li-Fraumeni syndrome (LFS). LFS is an autosomal dominant hereditary disorder. People with LFS have high risk of developing early onset cancers. We proposed LFSpro that is built on a Mendelian model and estimates …
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Evaluation of TP53 and IGHV clinical molecular prognostic testing for patients with Chronic Lymphocytic Leukaemia at Tygerberg Hospital
… variants in the tumour suppressor gene p53 (TP53) and mutational status of the immunoglobulin heavy chain variable region (IGHV) gene have emerged as critical molecular prognostic biomarkers with significant therapeutic implications for risk stratification and treatment selection. This study …
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Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations
… childhood cancer, and the frequency of germline TP53 mutations in families with multiple childhood tumors was investigated. The relatives of patients with childhood cancer were found to have an increased incidence of childhood and adult cancers, particularly of the breast and prostate. Breast and …
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Targeted gene therapy for canine osteosarcoma: preliminary investigations
… Hence, new approaches must be considered. TP53 is altered in ~50% of human and canine cancers, including OS, making it a candidate for targeted suicide gene therapy strategies. Canine OS is considered to be a good model for human OS. The aims of this study were to: examine the site …
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Activation of the p53 pathway in combination with photon irradiation for the treatment of neurological tumour cells
… radiotherapy. Molecular determinants, especially TP53 status, play a critical role in regulating tumour cell proliferation, cell-cycle control, and DNA damage response following irradiation. This study investigated the biological effects of the MDM2 inhibitor AMG232 in combination with photon …
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Exploiting p53 mutation in colorectal cancer: clinical positioning of Cdc7 inhibitors
Mutations in TP53 are present in approximately 50% of colorectal cancer (CRC) and are enriched for in the metastatic setting. As a result of TP53 mutation these tumours are limited in their ability to execute tumour-suppressive functions. Synthetic lethal targeting of pathways/ proteins on which …
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MUTANT P53 AS A THERAPEUTIC TARGET IN CANCER
Identifying therapeutic approaches to target TP53 mutations has the potential to revolutionize cancer treatment. TP53, the gene that encodes the prominent tumor suppressor protein p53, is mutated and inactivated in half of sporadic human tumors. Additionally, individuals who harbor germline TP53 …
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Modeling Renal Anomalies Associated with Li-Fraumeni Patients: A Novel Role for p53 in Kidney Development
… disorder caused by germline mutations in the <em>TP53 </em>gene that result in an increased risk of cancer. The <em>TP53</em> tumor suppressor gene regulates cell division and prevents the accumulation of cells that may become cancerous. LFS patients are susceptible to various types of cancers, …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… is often referred to as the "Genome Gatekeeper," TP53, is rarely inactivated in mesothelioma tumors. As TP53 is mutated in the majority of human cancers, in those cancers where TP53 is not mutated, its function may be regulated by other mechanisms. Evidence suggests that NF2 may be upstream in a …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… is often referred to as the "Genome Gatekeeper," TP53, is rarely inactivated in mesothelioma tumors. As TP53 is mutated in the majority of human cancers, in those cancers where TP53 is not mutated, its function may be regulated by other mechanisms. Evidence suggests that NF2 may be upstream in a …
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Modeling Cancer Using Li-Fraumeni Syndrome Patient-Derived Induced Pluripotent Stem Cells
… caused by germline mutations in the gene <em>TP53</em>, which predispose individuals to a wide range of malignancies, including osteosarcoma and breast cancer. In the previous study, our group developed a novel disease model platform by reprograming LFS patients' fibroblasts to induced …
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Reactive Oxygen Species and P21 Waf1/Cip1 Are Both Essential For
… biomarker to determine radioresistance is <em>TP53</em>, whose alterations are predictive of poor radiation response. The following work shows that the p53 transcriptional target, p21, is crucial in initiating and maintaining senescence in HNSCC, through its ability to regulate reactive oxygen …
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The Role of Nucleolin Phosphorylation by CK2 in Regulating Cellular Fate Under Normal and Stress Conditions
… with PARN deadenylase and the target gene <em>TP53 </em>mRNA, as well as with ARE-binding protein HuR to mediate HuR availability to their common target <em>TP53</em> mRNA. Dr. Kleiman’s lab determined that NCL can bind to the 3’UTR ARE of <em>TP53</em> mRNA under non-stressed conditions. …
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