Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"TOX"”.
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Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
… Whereas the transcription factor (TF) TOX has been identified as a critical initiator of Tex epigenetic programming, it remains unclear whether TOX plays an ongoing role in preserving Tex biology after cells commit to exhaustion. Here, we decoupled the role of TOX in the initiation …
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Técnicas de aprendizaje automático y computación científica aplicadas a la predicción de parámetros ADMET-Tox
… de su desarrollo debido al comportamiento ADME-Tox. Por estos motivos, el interes en la industria y el ambito academico en las disciplinas de quimioinformatica y, en particular, en las tecnicas de tipo QSAR ha crecido considerablemente en los ultimos a~nos. El objetivo de esta tesis se centro en …
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TOX2 and TOX at the intersection of central memory and exhaustion in human CAR T cells
… which limits their proliferation and cytotoxicity when chronically stimulated with antigen, such as in cancer. Genetic modification of CAR T cells is one approach to improve tumor killing capacity. We profiled a patient with chronic lymphocytic leukemia (CLL) who responded exceedingly well …
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Algal and bacterial interactions in producing precursors of trihalomethanes and other halogenated organics
… trihalomethane (THM) or total organic halogen (TOX) formation potentials of algal extracellular products (ECP), and (2) whether or not diurnal cycling of THM and TOX precursors occurs in vitro. These objectives were addressed through culture studies of heterotrophic microorganisms and pure algae …
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Three screening tests used to evaluate groundwater quality
… contamination due to materials leaching from toxic waste disposal sites and other sources has had a sobering impact on society. The rash of unexpected contamination has led to a plethora of legislation designed to address this problem. Along with this legislation has come the need to be able …
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The Reaction of Aqueous Free Chlorine With Organic Compounds Adsorbed on Granular Activated Carbon
… using a mass balance on total organic halogen (TOX), it was determined that chlorine residual entering a carbon bed did not react with adsorbed organics, or organics present in the pore water, to produce additional amounts of TOX. In all cases the TOX recovered on the carbon and in the effluent …
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Role of new virulence mechanisms/factors (type 3 secretion system and TOX-R regulated lipoprotein [TAGA]) in the pathogenesis of the emerging human pathogen Aeromonas hydrophila
… isolate SSU of A. hydrophila possesses a cytotoxic enterotoxin Act, a potent virulence factor that is secreted into the environment through the bacterium’s type 2 secretion system (T2SS) and possesses several biological activities, including cytotoxicity, enterotoxicity, and lethality in a …
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Regulation of Adaptive and Innate Immunity by the Circadian Transcription Factor NFIL3
… a High Mobility Group (HMG) transcription factor Tox directly in common lymphoid progenitors (CLPs). Accordingly, restoring Tox expression in Nfil3-deficient progenitors rescues ILC development in mice. So NFIL3 regulates ILC development by activating Tox expression in bone marrow precursors. …
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Fluorescence Based Approach to Drinking Water Treatment Plant Natural Organic Matter (NOM) Characterization, Treatment, and Management
… organic halogen formation potential (DBPFP and TOX-FP) were determined for the samples before and after coagulation. Parallel factor analysis (PARAFAC) was applied in order to generate independent models on different subsets of each drinking water treatment plant (DWTP) data set: (i) raw water, …
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Διερεύνηση των καρκινικών Τ κυττάρων στο δερματικό Τ κυτταρικό λέμφωμα
… Στις κηλίδες, κυριαρχεί ο φαινότυπος CCR4loTOXlo EM έναντι των CM, ενώ στις πλάκες παρατηρείται εμπλουτισμός σε CCR4+TOX+Th2/EM σε σύγκριση με τα Th2/CM. Αντίθετα, στους όγκους υπερισχύουν τα CCR4hiTOXhiTh2/CM έναντι των Th2/EM, τα οποία χαρακτηρίζονται από προχωρημένο βαθμό διαφοροποίησης …
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Seepage of Groundwater into the St. Clair River Near Sarnia, Ontario, Canada
… (extractables), total organic halides (TOX), chloride, and natural isotopes (oxygen-18, deuterium, and tritium). The average observed seepage rate of l. u x 10-8 m 3/s/m2 suggests higher chan expected hydraulic conductivity or hydraulic gradients in the streambed, 2 to 4 orders of …
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Molecular Epidemiology and Evolution of Corynebacterium diphtheriae and Vibrio cholerae
… available, including antibiotics and antitoxins. Vaccines are also available against both causative agents, although the diphtheria toxoid vaccine is in much wider use than cholera vaccine. In this thesis I have used genomics to investigate the epidemiology and evolution of both pathogens …
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Design, Synthesis, and Evaluation of Novel Antimycobacterial Agents With Enhanced Pharmacokinetic Profiles
… were assessed along with in vitro cytotoxicity profiles, pharmacokinetic and physicochemical parameters, including aqueous solubility, permeability, and human plasma protein binding. Based on the preliminary data, of the 39 compounds tested, compounds 192 and 200 were identified as the …
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Antimalarial Agents: New Mechanisms of Actions for Old and New Drugs
… side chain (1-87a and 1-88a) were extremely toxic to Akron mosquitos, yet these compounds did not exhibit appreciable selectivity between human and An. gambiae AChE. Unfortunately, none of the nitriles showed appreciable toxicity to G3 strain of the mosquitoes, nor did they inhibit An. …
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Management of the UK plutonium stockpile using thorium fuelled Light Water Reactors
… lower decay heat, radioactivity, and radiotoxicity - though the differences between Th-Pu and U-Pu MOX SNF are small enough that this will offer only limited benefits from a handling and disposal perspective. The potential profits associated with recycling the stockpile are comparable …