Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"TORC2"”.
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TORC2 and Eisosomes Are Spatially Interdependent, Requiring Optimal Level of Pi(4,5)P<sub>2</sub> for Their Integrity
… between the protein complexes eisosome and TORC2, representing microdomains MCC and MCT, respectively. In this study, I reveal that the eisosome organizer Pil1 colocalizes with the MCT marker Avo2. Furthermore, I provide evidence that the formation of MCT is dependent on both eisosome …
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Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae
… of an essential protein, Lst8, in TORC1 and TORC2 signaling and a previously uncharacterized complex, the Far3-7-8-9-10-11 complex (Far complex) in the budding yeast, <em>Saccharomyces cerevisiae</em>. Mutations in <em>SAC7</em> and <em>FAR11</em> suppressed lethality of both <em>lst8</em> …
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The role of Serum- and Glucocorticoid kinase in the hormonal control of sodium transport in pulmonary epithelia
… residues by the target of rapamycin complex 2 (TORC2) and phosphoinositidedependent Kinase 1 (PDK1), both of which are dependent upon Phosphoinositide-3-Kinase (PI3K). However, SGK1 knockout mice do not display any pulmonary abnormalities. Thus the role that SGK1 plays is not fully understood. …
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Insights into the regulation of mTOR signaling and the consequences of pharmacological inhibition
… can be decoupled. The TOR complexes, TORCI and TORC2, are central regulators of cell growth and share the serine/threonine TOR kinase as their catalytic domain. In mammals, the TORC2 homolog mTORC2 is activated by growth factors through the lipid kinase PI3K, and is a primary effector for many …
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Hormone-induced expression of the epithelial sodium channel in human airway cells
… gene product must then be phosphorylated via TORC2 and PDK1, protein kinases activated via the P13-kinase pathway. Once activated, SGK1 appears to exert control over the surface abundance of ENaC subunits by phosphorylation, and thus inactivating, a ubiquitin ligase (Nedd4-2), that normally …
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Strategies to Sensitize Bladder Cancer Cells to Small Molecule Inhibitors Targeting The Pi3K Pathway
… mTOR inhibitor, which targets both TORC1 and TORC2. In this thesis, I investigate the link between sensitivity to small molecule inhibitors targeting the PI3K pathway and the genetic signature of a large panel of bladder cancer cell lines. I investigate novel strategies to sensitize bladder …
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Regulation of mTOR complex 1 in response to growth factors and nutrients
… complex 1 and 2 (TORC1 and 2). The activity of TORC2 is mainly regulated by growth factors, whereas TORC1 activity is responsive to both growth factors and nutrients, and thus acts as a detector of favorable growth conditions. The consequence of TORC1 activation is increased protein translation …