Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"TORC1"”.
-
Roles of the TORC1 Signaling in Stress Response and Chronological Lifespan Extension in Yeast
… the conserved target of rapamycin complex 1 (TORC1) pathway. In Saccharomyces cerevisiae, enhanced mitochondrial ROS signaling and hyper-accumulation of storage carbohydrates are the two major models to account for chronological lifespan (CLS) extension in TORC1-compromised cells. However, to …
-
Yeast Ataxin-2 (Pbp1) Condensates Regulate TORC1 Activity and Autophagy in Response to Cellular Redox State
… I identified Pbp1 as a dedicated regulator of TORC1 signaling and autophagy under conditions that require mitochondrial respiration. Unlike the autophagy-deficient atg mutants that harbor severe growth defects, pbp1 null mutants exhibited significantly increased cell growth despite lack of …
-
Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms
… such as the target of rapamycin complex 1 (TORC1), to downstream chromatin modifying enzymes. These enzymes impact the gene regulatory process through altered histone post-translation modifications, changes in chromatin structure, and docking of chromatin regulatory complexes. Yet, despite …
-
Combined Inhibition of SREBP and m-TORC1 Signaling Synergistically Inhibits the Proliferation of B Cell Lymphoma
… However, B cell lymphoma cells activate the mTORC1-pS6 pathway in response to statin treatment, suggesting a possible mechanism to counteract statin-induced cell cycle arrest. Combining low dose statin treatment with the mTORC1 inhibitor rapamycin demonstrates a synergistic effect in …
-
Regulation of mTOR complex 1 in response to growth factors and nutrients
… protein complexes known as TOR complex 1 and 2 (TORC1 and 2). The activity of TORC2 is mainly regulated by growth factors, whereas TORC1 activity is responsive to both growth factors and nutrients, and thus acts as a detector of favorable growth conditions. The consequence of TORC1 activation is …
-
dLipin-A Link between Lipid Metabolism, Glucose Homeostasis and Growth in Drosophila melanogaster
… I found that the nutrient sensing complex TORC1 regulates dLipin activity in lipid metabolism by controlling dLipin's subcellular localization. Hence, the insulin pathway as well as the TORC1 pathway each appears to be a central regulator of dLipin activity and its functions in lipid …
-
Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae
… the function of an essential protein, Lst8, in TORC1 and TORC2 signaling and a previously uncharacterized complex, the Far3-7-8-9-10-11 complex (Far complex) in the budding yeast, <em>Saccharomyces cerevisiae</em>. Mutations in <em>SAC7</em> and <em>FAR11</em> suppressed lethality of both …
-
Yeast Ataxin-2, A Protein with Many Friends: Identification of a Novel Role for Pbp1 in Mitochondrial Biogenesis
… binding protein and a negative regulator of TORC1. Previous work showed that cells lacking Pbp1 in respiratory conditions exhibited mitochondrial dysfunction. I thus hypothesized that Pbp1 has an essential role in mitochondrial respiration. Utilizing genetics and biochemical assays, I …
-
The role of Serum- and Glucocorticoid kinase in the hormonal control of sodium transport in pulmonary epithelia
… abolished ENaC activity. However inhibition of TORC1 had no effect upon dexamethasone induced ENaC activity. Thus demonstrates that the maintenance of glucocorticoid induced ENaC activity, in pulmonary epithelium, is dependent upon the PI3K-TORC2-SGK1 signalling pathway. Furthermore PI3K plays a …
-
Strategies to Sensitize Bladder Cancer Cells to Small Molecule Inhibitors Targeting The Pi3K Pathway
… and double mTOR inhibitor, which targets both TORC1 and TORC2. In this thesis, I investigate the link between sensitivity to small molecule inhibitors targeting the PI3K pathway and the genetic signature of a large panel of bladder cancer cell lines. I investigate novel strategies to sensitize …
-
Insulin and TOR pathways regulate cellular and organismal growth through the myc oncogene in Drosophila
… while its mRNA does not seem to be affected upon TORC1 inhibition, suggesting that the Nutrient pathway regulates dMyc mostly post-transcriptionally. In support to this hypothesis, we observed a TORC1-dependent GSK3β/sgg inactivation, further confirming a synergic effect of DILPs and Nutrients on …
-
The role of the environmental stress response in aneuploid and cell cycle-arrested budding yeast
… ribosome loss occurs in cells when either the TORC1 pathway or Ras/PKA pathway is inhibited. When I hyperactivate the Ras/PKA pathway during cdc-ts arrests, cells no longer exhibit the ESR and have significant loss of viability. I show that these strains no longer downregulate ribosomes and …