Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"TOR signaling"”.
-
Tor Signaling in the Fungal Kingdom
… nutrients through multiple interconnected signaling networks, which allow them to adjust their metabolism, transcriptional profiles and developmental programs to adapt readily and appropriately to changing nutritional states. In organisms ranging from yeasts to humans, the Tor signaling …
-
Modulation of plant growth by day length dependent regulation of the TOR signaling pathway
… plant of day length duration (photoperiod). The TOR (Target of Rapamycin) kinase pathway is a central hub where cellular energy levels are perceived and translated into specific growth responses across kingdoms. In plants, the TOR pathway has been associated with rapid growing tissue including …
-
Investigation of the Role of TOR and Nutrient Restriction on Lifespan of Arabidopsis thaliana
<p>The Target of Rapamycin (TOR) kinase is evolutionarily conserved and is a key regulator, controlling many cellular functions to promote survival and growth in all eukaryotes. Several model organisms have indicated a relationship between TOR signaling and life expectancy, such as yeast, fruit …
-
An investigation of nutrition-dependent mRNA translation in Drosophila larvae
… acids have been shown to be important regulators of translation in animal cells. I have determined that neither sugars nor amino acids were sufficient to maintain translation in larvae removed from food. However, a complex diet such as yeast was sufficient to maintain translation in larvae …
-
Platiscity of C. Elegans Germline Stem Cells Under Nutritional and Metabolic Stress
… the short G1 is promoted by the metabolic regulator <em>gsk-3</em>. Loss of <em>gsk-3</em> inhibits S phase entry and progression through transcriptional down-regulation of <em>cdk-2</em>. Since metabolic signaling regulates <em>gsk-3</em>, I propose that controlling G1 progression may allow the …
-
Characterization of metabolomic dynamics in synchronized Chlamydomonas reinhardtii cell cultures and the impact of TOR inhibition on cell cycle, proliferation and growth
… Ser/Thr protein kinase “Target of Rapamycin” (TOR) has emerged as a major signaling node that integrates the sensing of numerous growth signals to the coordinated regulation of cellular metabolism and growth. Although the TOR signaling pathway has been widely studied in heterotrophic organisms, …
-
Regulation of GAP1 permease sorting in Saccharomyces cerevisiae
… of the MKS] gene, which encodes a negative regulator of glutamate synthesis, increased glutamate and glutamine levels and increased sorting of Gaplp to the vacuole. We also found that the LST8 gene, which was previously implicated in the regulation of Gap lp sorting, encodes a positively-acting …
-
Transcriptional effects of predator cues in the brain of Spodoptera frugiperda (lepidoptera: noctuidae) moths exposed to bat ultrasound
Exposure to predators induces broad behavioral and physiological responses that have traditionally been considered acute and transitory. However, prolonged frequent exposure to predators and the chemical, visual, tactile, and auditory cues they broadcast to the environment are now known to have …
-
CDC45 Function Alters Cell Sensitivity to DNA Topoisomerase I Poisons
… conserved enzyme that functions to manage the torsional strain of DNA during cellular processes such as transcription, replication, chromatid condensation and recombination. The enzyme binds duplex DNA and through a series of strand cleavage and religation reactions removes positive or negative …
-
dLipin-A Link between Lipid Metabolism, Glucose Homeostasis and Growth in Drosophila melanogaster
… TAG) and as transcriptional co-regulators that affect the expression of genes involved in lipid and fatty acid metabolism. Thus, they play central roles in metabolic control. Disruption of Lipin function has been implicated in lipodystrophy, obesity and insulin resistance. Using …
-
Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae
… the function of an essential protein, Lst8, in TORC1 and TORC2 signaling and a previously uncharacterized complex, the Far3-7-8-9-10-11 complex (Far complex) in the budding yeast, <em>Saccharomyces cerevisiae</em>. Mutations in <em>SAC7</em> and <em>FAR11</em> suppressed lethality of both …