Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"TOR pathway"”.
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Role of UV90 Gene in the FRQ-Less Oscillator of the Neurospora Crassa Circadian System
… to be driven by one or more FRQ-less oscillators (FLOs). Through UV mutagenesis former lab members have found a mutation (uv90) that compromises FRQ-less rhythms and also affects rhythmicity when FRQ is functional, demonstrating the close integration between the TTFL and FLO(s). My PhD …
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Modulation of plant growth by day length dependent regulation of the TOR signaling pathway
… plant of day length duration (photoperiod). The TOR (Target of Rapamycin) kinase pathway is a central hub where cellular energy levels are perceived and translated into specific growth responses across kingdoms. In plants, the TOR pathway has been associated with rapid growing tissue including …
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The localization of mTORC1 signaling
… as being coordinated by the Target of Rapamycin (TOR) Pathway. TOR is a serine/threonine kinase that resides in two distinct protein complexes which in mammals are referred to as mTORC1 and mTORC2. While significant emphasis has been placed on defining which pathways TOR controls and on how TOR …
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Genetic Mechanisms Responsible for Dietary Restriction Dependent Lifespan Extension in Drosophila Melanogaster: A Role for Muscle Tissue
… nutritional manipulations and laboratory selection for lifespan were simultaneously applied. Three physiological outputs were used for the screening and characterization of genes that may mediate the effects of DR: starvation resistance, spontaneous activity levels, and lifespan. The …
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Regulation of GAP1 permease sorting in Saccharomyces cerevisiae
… the glutamate and glutamine biosynthesis pathways have a pronounced effect on the intracellular sorting of Gaplp. Mutations in the genes encoding the principal enzymes for glutamate and glutamine synthesis, GDH1 and GLN1, decreased intracellular levels of glutamate and glutamine, …
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Investigating neuronal mitochondrial DNA loss in Drosophila melanogaster
… TFAM RNAi or overexpression specifically in motor neurons causes locomotion defects during development and age-related behavioural defects in adult flies. This demonstrates that maintenance of mtDNA is required for normal motor neuron function.<br/><br/>In further behavioural assays we show …
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Investigation of the Role of TOR and Nutrient Restriction on Lifespan of Arabidopsis thaliana
<p>The Target of Rapamycin (TOR) kinase is evolutionarily conserved and is a key regulator, controlling many cellular functions to promote survival and growth in all eukaryotes. Several model organisms have indicated a relationship between TOR signaling and life expectancy, such as yeast, fruit …
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Regulation of mTOR complex 1 in response to growth factors and nutrients
… the simultaneous availability of growth factors and nutrients before they invest in cellular processes that lead to growth. The TOR kinase is a master regulator of cellular growth and nucleates two distinct protein complexes known as TOR complex 1 and 2 (TORC1 and 2). The activity of TORC2 …
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Tor Signaling in the Fungal Kingdom
… In organisms ranging from yeasts to humans, the Tor signaling pathway responds to nutrient-derived signals and orchestrates cell growth. While in the baker's yeast <italic>Saccharomyces cerevisiae</italic> Tor responds to nutrient-derived signals and orchestrates cell growth and proliferation, in …
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PHDS, Stress, And Starvation: The Identification Of A New RPD3 Deacetylase Complex Involved In The Yeast Oxidative Stress And Metabolism Pathways
<p>The cellular pathways that govern survival in the face of diverse stresses rely on gene expression changes as one mechanism to respond to or protect against internal and external threats. Because eukaryotic DNA is packaged into chromatin, these gene expression changes depend on the targeting of …
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The evolution of ribosomal protein paralogues and their roles in development
… diseases known as ribosomopathies. Historically, translation has been viewed as a constitutive process, with ribosomes being machines with little to no independent influence on gene expression. However, translation is now known to be highly regulated, and growing evidence has shown that …
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Nutrition, Hormones, Transcriptional Regulatory Networks and Division of Labor in Honey Bee Colonies
… stimulate feeding and the mobilization of stored nutrients to meet an individual’s immediate energetic needs. But prolonged food deprivation can also lead to much longer-term effects, causing individuals to enter extended periods of inactivity, alter their reproductive strategy, or lose …