Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"TNFalpha"”.
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TNFalpha expression in monocytes/macrophages
The recognition of microbes or microbial products by leukocytes is a key event in innate immunity. Binding of microbial products to cell surface receptors on phagocytes induce a response that includes the production of inflammatory mediators. One such mediator is the cytokine tumour necrosis factor …
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Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha
… cytokine tumor necrosis factor alpha (TNFalpha) in the vascular response to hyperglycemia. NFAT is a Ca2+-dependent transcription factor which was originally described in immune cells. The NFAT family consists of four isoforms (NFATc1-c4), all of which depend on dephosphorylation by the …
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Evaluation of IP-10 and TNFalpha-transducing parvoviral vectors as antitumoral agents in animal glioblastoma models
… vectors expressing human IP-10 or mouse TNFalpha as tools against subcutaneous glioblastoma tumors in two animal models. First, new recombinant MVMp- and H1- based vectors expressing human IP-10 or mouse TNFalpha were constructed. It was shown that parvoviral vectors could effectively …
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Verstärkung Butyrat induzierter Apoptose in kolorektalen Karzinomzellen durch Aspirin und Tumor Nekrose Faktor alpha
… gegenüber dem Kolonkarzinom. Für das Zytokin TNFalpha werden einerseits apoptoseinduzierende Effekte für kolorektale Karzinomzellen in vitro beschrieben, jedoch gelten einige Kolonkarzinomzellinien als resistent gegen TNFalpha. Andererseits besitzt TNFalpha auch proinflammatorische und …
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Cytokine-Induced Igf-I Resistance in Progenitor Muscle Cells
… low, physiologically relevant concentrations of TNFalpha and IL-1beta suppress the ability of IGF-I to induce global protein synthesis and expression of myogenic transcription factors that are needed for differentiation of murine progenitor muscle cells. We significantly extend these results by …
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Cytokines and human endometrial function: Abnormalities in recurrent miscarriage women.
… (IL-1beta) and tumour necrosis factor alpha (TNFalpha) in the human endometrium of normal fertile women throughout the menstrual cycle. The results showed that staining intensity for LIF and IL-6 increased in epithelial cells at the time of implantation. IL-1alpha and IL-1beta remained …
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Cellular and Molecular Mechanisms Involved in the Induction of the Lipostatic Cytokine Leptin by Tumor Necrosis Factor Alpha
… at many levels. Initial studies determined that TNFalpha could act directly on adipocytes to stimulate increased leptin secretion through the p55 TNF receptor (TNFR). This was an important first step, since it allowed us to identify potential intracellular signaling pathways activated by the p55 …
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Einschränkung hepatischer Abwehrreaktionen während einer Entzündung durch Prostaglandin E2 über Gs-Protein-gekoppelte Prostaglandin E2-Rezeptoren
… und aufrechterhalten durch Cytokine, wie z. B. TNFalpha (Tumor Nekrose Faktor alpha) und IL-6 (Interleukin-6). Diese Cytokine werden u. a. in großen Mengen lokal in der Leber durch die dort residenten Makrophagen, die Kupfferzellen produziert. Kupfferzellen setzen neben Cytokinen auch …
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Aging Exacerbates the Brain Response to a Peripheral Immune Stimulus
… pro-inflammatory cytokines (IL-1beta, IL-6, and TNFalpha) that convey a message to the brain to stimulate microglia and elicit sickness behaviors. However, excessive or prolonged release of cytokines can cause severe behavior deficits and neurotoxicity. Because neurobehavioral deficits are …
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Expression, activation, and regulation of matrix metalloproteinase 2 (MMP-2) in the bovine corpus luteum
… luteal cells. In a luteal cell culture system, TNFalpha stimulated MMP-2 expression in a dose and time dependent manner. In luteal-derived endothelial cells, TNFalpha increased while IFNgamma inhibited MMP-2 expression. In the presence of both cytokines, IFNgamma attenuated the stimulatory …
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Mechanisms of Cytokine-Induced IGF -I Insensitivity in Cancer Cells
… cytokines, tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), inhibit IGF-I-promoted DNA synthesis in human MCF-7 breast adenocarcinoma cells, T-47D breast ductal carcinoma cells, murine FDCP progenitor myeloid cells and human promyeloid HL-60 …
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Variazione dei markers di attivata coagulazione indotta dalla terapia infusionale con Infliximab in pazienti affetti da malattie infiammatorie croniche intestinali
… particular, pro-inflammatory cytokines, such as TNFalpha, promote the activation of coagulation and reduce the production of anticoagulant molecules. It is known that inflammatory bowel diseases show a prothrombotic state and a condition of hypercoagulability. Aim of our study was to evaluate …
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The Regulatory Role of Mixed Lineage Kinase 4 Beta in MAPK Signaling and Ovarian Cancer Cell Invasion
… also negatively regulates basal, but not TNFalpha-induced, NF-kappaB activity. Moreover, MLK4beta; undergoes autophosphorylation and has kinase activity towards histone H2A, but has no kinase activity towards the MAP2K, MEK4/SEK1, a known substrate for MLK3 and other MAP3Ks. Furthermore, …
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The functions of pregnancy-associated plasma protein A in rheumatoid arthritis.
… and the cytokines IL-1, IL-6 and TNFalpha using commercial ELISA kits from Biosource International. IL-1alpha stimulated the production of PGE[2] and IL-6 in the MG-63 cells, whereas PAPP-A had no significant effect on basal or IL-1alpha stimulated IL-6 and PGE[2] production. In …
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Immunevasion von Herpes-simplex-Virus Typ 1: Angriff auf Zellen des Immunsystems
… kann. In infizierten Zellen war die Menge an TNFalpha und TRAIL stark erhöht. Die Menge an CD95L blieb jedoch unverändert. Da unreife Dendritische Zellen resistent gegen einen durch Todesliganden induzierten Zelltod sind, müssen Viren diese Zellen durch einen veränderten Signalweg empfänglich …
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Studies of Atherosclerosis in Systemic Lupus Erythematosus
… of apoptotic cells, there was increased TNFalpha, IL-12p40, IL-6, MCP-1, and IL-10 gene expression in response to six hours of 100 ng/ml of LPS treatment independent of 1 x 10 ^ -9 M 17beta-estradiol treatment. Our findings indicate that some cynomolgus macaques may be susceptible to the …
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Immunomodulatory Roles of the Lysosomal Sialidase Neuraminidase 1
… these cells release increased levels of CCL3 and TNFalpha. Furthermore, we showed that lysosomal exocytosis contributes to the release of these signaling molecules by microglia. In the next section of the results, we established that Neu1 KO microglia have a reduced phagocytic capacity for …
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Untersuchung des CRM1-abhängigen RNA-Exports mittels Repräsentativer Differenz-Analyse
… konnten 11 verschiedene Transkripte wie z.B. die TNFalpha- oder die CD83-mRNA identifiziert werden, die eine veränderte Kern/Cytoplasma-Verteilung nach LMB-Behandlung zeigten. Mit Northernblot- und RT-PCR-Analysen konnte zusätzlich bewiesen werden, daß die Transkription der meisten untersuchten …
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The in vitro effects of chemokines on microglia: Implications for multiple sclerosis.
… proinflammatory cytokines such as IFNgamma and TNFalpha and respond by secretion of cytokines, chemokines, proteases, nitric oxide and superoxide radicals. As MS is a putative autoimmune disease of the CNS, chemokines (chemotactic cytokines), secreted by many cell types including T cells and …
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Determinants of clinical phenotype in myeloproliferative neoplasms
… across MPN subtypes, with high levels of TNFalpha and IP-10 seen in myelofibrosis, and to a lesser extent in polycythemia vera. Patients with essential thrombocytosis however, were found to have high levels of GROalpha and EGF, and levels of these at single time points or when measured …
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