Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"TNFR1"”.
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Analyse der Funktion von Signaladaptoren zelltodvermittelnder Rezeptoren
… auf welchem Wege die beiden Zelltodrezeptoren TNFR1 und Fas Apoptose in den Zelllinien A9 und SV80 ausführen. Ausgangspunkt waren widersprüchliche Erkenntnisse über die Signalwege von TNFR1 und Fas. So war in der Literatur beschrieben, daß TNFR1 und Fas die gleichen intrazellulären …
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Identification and characterization of innate immune receptor substrates of γ-secretase enzyme complex
… the Tumour necrosis factor receptor type 1 (TNFR1) and the Toll like receptor 4 (TLR4) as novel γ-secretase substrates. Secondly, given that the diversity of signalling events mediated by the IL-1R1, TLR4 and TNFR1 are spatially segregated, we investigated the spatial distribution, …
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Interactions of viral and cellular Tumour Necrosis Factor Receptor molecules
… cytokine, acting via two cellular receptors, TNFR1 and TNFR2 that induces apoptosis and inflammation. Poxviruses encode homologues of TNF-receptors (viral TNFRs) that independently interact with both TNF, and simultaneously with cellular TNFRs, to subvert TNF-induced anti-viral apoptosis. The …
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Targeting pro-inflammatory mediators to treat visceral pain
… p38 MAPK activity respectively, downstream of TNFR1 receptor activation. I therefore sought to investigate whether TNFR1-evoked p38 MAPK activity is also involved in TNFα sensitisation of colonic afferent responses to capsaicin and noxious distension of the bowel. In Ca2+ imaging of DRG …
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Calpain 9 Functions in TNF Receptor Mediated Apoptosis
… for RIPK1 recruitment and ubiquitination at the TNFR1 upon activation with TNF-alpha. CAPN9 knockdown demonstrates previously unreported association of ubiquitinated proteins, and actin binding proteins with TNFR1 in the absence of stimulus. This interaction is CAPN9 dependent and correlates with …
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Screening of the human tumor necrosis factor (TNF) gene and its receptor 1 (TNFR1) gene for DNA alterations and the subsequent investigation of these and an IL12p40 polymorphism for an association with paediatric tuberculosis
… for DNA sequence alterations in the TNF and TNFR1 genes. The individuals in this cohort were selected on the basis of their whole blood stimulation assays, where either high or low levels of TNF in response to non-specific stimulatory factors, were the determining criteria. It was assumed …
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Identification of the role of transcription factor ETV7 in breast cancer aggressiveness
… BC cells. We identified TNFRSF1A, encoding for TNFR1, as one of the genes repressed by ETV7. We demonstrated that ETV7 directly bound to the intron I of this gene, and we showed that the ETV7-mediated down-regulation of TNFRSF1A reduced the activation of NF-κB signaling. These results suggest …
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Identification of the molecular pathways that mediate cytokine induced immunopathology of the gut epithelium
… synergistic cell death. While TNF receptor-1 (TNFR1) was also required, there was no direct dependency of cell death on TNFR1-downstream canonical apoptotic and necroptotic signalling pathways. Furthermore, we identified a non-canonical role for caspase-8 and receptor-interacting …
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NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity
… was also associated with altered free and bound TNFR1 levels on day 13 in vitro. TNFR1 acts upstream of RIP1 and suggests that these differences may be due to NF-kB independent functions of NIK. Overall, these results provide further insight into the potential mechanisms underlying …
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Estudio Farmacogenético de la Respuesta al Anticuerpo Monoclonal Anti-CD20 (Rituximab) en el Tratamiento de Pacientes con Linfoma Folicular.
… tales como FAS, FASL, TRAILR1, TRAIL y TNFR1, que puedan influir en la variabilidad de la respuesta podría ser útil en el manejo clínico de los pacientes con linfoma folicular tratados con rituximab. Por el momento, no existen estudios publicados que analicen la influencia de estos …
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Analisi funzionale dei recettori per le neurotrofine p75NTR e Trka in neuroblastoma
… one adopted by Tumor Necrosis Factor Receptor 1 (TNFR1), when activated by TNFa. We define that in neuroblastoma cell line Ab cytotoxicity signals through a pathway depending on p75NTR death domain (DD), mostly through some specific conserved residues. We identified that TRADD is the first …
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Acute Pro-inflammatory Immune Response Following Different Resistance Exercise Protocols in Trained Men
… Plasma testosterone concentrations and TNFr1 receptor expression did not appear to be affected by resistance exercise. Our results do not support a role for cortisol in the modulation of CCR2 receptors in vivo, while the degree of muscle damage does not appear to influence plasma …
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Impact of Leucine and HMB on Acute Muscle Damage: Focus on Repair and Regeneration in vivo and in vitro
… (P < 0.05) increased vs. males, with TNFR1- also non-significantly increased. Replicatively aged myoblasts migrated significantly (P < 0.05) faster than control myoblasts, with the inhibition of Akt significantly (P < 0.05) blocking migration. Both models responded to supplements …
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Pre-clinical evaluation of inhibitors of apoptosis protein (IAP) antagonists in colorectal cancer
… mechanisms. When TNFα binds to its receptor TNFR1 in the presence of an IAP antagonist, it leads to the formation of a cytoplasmic death-inducing complex consisting of RIPK1, FADD and procaspase-8. Procaspase-8 undergoes homodimerization within this complex and subsequently activates effector …
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Zytokinrezeptorpolymorphismen bei Patienten mit T-Non-Hodgkin-Lymphomen
Bestimmte Genvariationen in Zytokingenen und Zytokinrezeptorgenen sind mit der Suszeptibilität und Prognose von Lymphomen assoziiert. Dieser Zusammenhang ist vor allem für B-Zell-Lymphome beschrieben worden. In der vorliegenden Arbeit wird anhand von 117 DNA-Proben und 80 Serumproben von …