Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"TNFR"”.
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Exploring a Novel Mechanism of Reguation of the TNFR Family Member FN14
Fibroblast growth factor-inducible 14 (FN14) is a highly inducible cytokine receptor linked to a number of intracellular signaling pathways, including the nuclear factor-kappaB (NFkB) and mitogen-activated protein kinase (MAPK) pathways, as well as to physiological processes, such as angiogenesis, …
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Inflammatory Cytokine Mediated CNS Damage: Insights Into the Effects of Tnf-Alpha From a Neuronal Cell Line
… N1E's express mRNA for one of two TNF receptors (TNFR's) and also express membrane-associated TNF. TNF is toxic to both undifferentiated and differentiated N1E's in the presence of the transcriptional inhibitor, actinomycin D and the anti-viral cytokine, interferon-$\alpha/\beta.$ Only …
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Regulation of tumour necrosis factor receptor expression on neutrophils by arachidonic acid and other long chain fatty acids.
… responsive to TNF and the soluble TNF receptors (TNFR) serve to control TNF activity. During inflammation, leukocytes become activated as a result of the action of a variety of mediators. These mediators include not only cytokines but also lipids, such as the pro-inflammatory 00-6 fatty acid, …
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Interactions of viral and cellular Tumour Necrosis Factor Receptor molecules
… cytokine, acting via two cellular receptors, TNFR1 and TNFR2 that induces apoptosis and inflammation. Poxviruses encode homologues of TNF-receptors (viral TNFRs) that independently interact with both TNF, and simultaneously with cellular TNFRs, to subvert TNF-induced anti-viral apoptosis. The …
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Mechanisms of TRAF Signaling
… Ligands of the TNF family engage TNF receptor (TNFR) family proteins, leading to a wide variety of cellular effects, these interactions are implicated in inflammation, immune regulation, bone homeostasis, and development. TNFR proteins lack intrinsic enzymatic activity, and are coupled to …
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Investigating the function of TRAF1 in NF-κB activation
… of the tumour necrosis factor receptors (TNFR) and toll-like receptors (TLR) signalling pathways. In the TNFR pathway, TRAF1 recruits c-IAP2 to promote NF-κB activation and cell proliferation. In contrast, in TLR pathways, TRAF1 negatively regulates NF-κB by sequestering the linear …
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Identifying TRAF1 Mutations as a Key Step to Develop a Targeted Therapy for Rheumatoid Arthritis
… inflammation. Tumor necrosis factor receptor (TNFR)- associated factor 1 (TRAF1) has been implicated in disease development. TRAF1 is a signalling adapter downstream of TNFR and Toll-like receptors (TLR), where it plays opposing roles in the activation of nuclear factor-k-B, NF-κB. Downstream …
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The role of TNFRp55 and TNFRp75 in the host immune response to Mycobacterium tuberculosis
… against Mycobacterium tuberculosis infection. TNFRp55 and TNFRp75 can both bind TNFα and conduct signaling, however the respective roles, in particular that of TNFRp75 in an M. tuberculosis aerosol inhalation infection was poorly defined. In this study the role of signaling through TNFRp55 and …
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Cellular and Molecular Mechanisms Involved in the Induction of the Lipostatic Cytokine Leptin by Tumor Necrosis Factor Alpha
… leptin secretion through the p55 TNF receptor (TNFR). This was an important first step, since it allowed us to identify potential intracellular signaling pathways activated by the p55 TNFR that might lead to leptin gene expression. Subsequent studies found that a highly specific inhibitor of p38 …
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Mechanism of Chimeric Vaccine Mediated Immune Suppression of Human Dendritic Cells
… may function in the same signaling pathway as TNFR super-family for the up-regulation of IDO1 biosynthesis in vaccinated dendritic cells. Together, these data confirm CTB-INS vaccine activation of the non-canonical NF-κB signaling pathway TNFR receptor family up-regulation of dendritic cell …
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Zur Rolle des CD30 Liganden bei der Induktion einer spezifischen Immunantwort gegen Melanomzellen
… geworden sind. Die Mitglieder der TNFR Familie können zusätzliche Aktivierungssignale zur Aktivierung von T-Zellen liefern. CD30L wurde im Vergleich zu B7-1 als kostimulatorisches Molekül evaluiert. CD30L und B7-1 konnten auf Melanomzellen stabil zur Expression gebracht werden. …
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Investigating transmembrane TNF and transmembrane p55TNFR mediated signaling in host immune function during Mycobacterium tuberculosis infection
The importance of TNF-TNFR signaling in immunity against M. tuberculosis has been established. The aims of this study were to characterize the functions of membrane-bound TNF (Tm-TNF) and soluble TNF (solTNF) and to investigate the role of membrane-bound p55TNFR signaling as well as the in vivo …
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Freqüências de variantes alélicas de genes ligados ao sistema imunológico em uma população de indivíduos de origem japonesa no sul do Brasil
… Polimorfismos bialélicos dos genes CCR5, TNFR-II e IL-10, e dos segmentos gênicos TCRBV3S1, TCRBV13S5 e TCRBV18 foram analisados por PCR-RFLP. As freqüências alélicas foram determinadas e comparadas com as freqüências encontradas em outros grupos étnicos (caucasóides e afro-brasileiros). …
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Untersuchungen über die funktionelle Rolle des Neurotrophinrezeptors p75NTR
… Darüber hinaus konnte gezeigt werden, dass auch TNFR, wie p75NTR ein Mitglied der TNFR-Überfamilie, RhoA aktiviert, obgleich mit einer klar unterschiedlichen Kinetik. Die TNFa-vermittelte Regulation von RhoA hemmte das Auswachsen von Neuriten. Im cerebellären Kultursystem konnte jedoch kein …
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Characterisation of the Helix pomatia agglutinin binding glycoproteins of colorectal cancer cell lines and tissue samples
… pathways (Hsp-70, Hsp-90, Hsp-96 and TNFR-1). Although many of these proteins have previously been described as altered in cancer, we are not aware of a single reagent like HPA which will concurrently bind all of these molecules.
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Gain And Loss Of Progranulin Have Opposite Effects On Autophagy
… activation of autophagy through TNF receptor (TNFR) over-stimulation and C-Jun N-terminal kinase (JNK) activation. Excessive activation of brain autophagy is associated to neurodegeneration and either JNK or autophagy inhibition improve neuronal viability and dysfunction in PGRN deficient …
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Identification and characterization of innate immune receptor substrates of γ-secretase enzyme complex
… the Tumour necrosis factor receptor type 1 (TNFR1) and the Toll like receptor 4 (TLR4) as novel γ-secretase substrates. Secondly, given that the diversity of signalling events mediated by the IL-1R1, TLR4 and TNFR1 are spatially segregated, we investigated the spatial distribution, …
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Tnf Signaling During Tissue Damage-Induced Nociceptive Sensitization In Drosophila
… of TNF/Eiger, downstream signaling mediators for TNFR/Wengen, and target genes that alter nociceptive behaviors. Here we show that apoptotic cell death and thermal allodynia are genetically and procedurally independent of each other while initiator caspase Dronc is required for both. An apoptotic …
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Control of DAPK-1 degradation
… of full-length DAPK-1 and apoptosis induced by TNFR-1. Moreover, siRNA mediated knock-down of DAPK-1 enhanced TNF-α induced apoptosis, confirming the role of DAPK-1 as a survival factor in the TNF-α signalling pathway. In addition, a splice variant of DAPK-1, which I have called s-DAPK-1, was …
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A Non-Canonical Function for NLRP3 and AIM2 in Kidney Diseases
… of NLRP3/ASC/caspase-8 specks was downstream of TNFR signaling and independent of caspase-1 or -11 activation. This data shows that NLRP3 and ASC form a conserved non-canonical platform for caspase-8 activation, independent of the inflammasome that regulates apoptosis within epithelial cells. …
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