Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 156 for “"TNF-alpha"”.
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Effects of Liposome-Encapsulated TNF-Alpha and Radiation against Colon Cancer
… studies have shown that tumor necrosis factor-α (TNF-α) can augment the antitumor effects of radiation, inhibiting tumor progression to a greater extent than either modality alone. However, nonspecific toxicities associated with TNF-α have limited its use as an adjuvant. This limitation is …
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A Preclinical Model of Ionizing Radiation and TNF-alpha Gene Therapy for Cancer
… plasmid DNA expressing Tumor Necrosis Factor-α (TNF-α) could enhance the effect of ionizing radiation in an aggressive, rapidly growing glioma tumor (C6) model. Plasmid DNA is an attractive vector system for delivery of foreign genes into eukaryotic cells due to its advantages including low …
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Die Rolle des Tumorsuppressors p53 für die TNF-alpha-vermittelte Induktion des MCP-1-Gens
… Interleukin-1 (IL-1) und Tumor-Nekrose-Faktor-alpha (TNF-alpha). Das Gen, welches für MCP-1 codiert, ist ein "immediate-early" Gen. Die Induktion des MCP-1-Gens durch TNF-alpha wird auf der Ebene der Initiation der Transkription hauptsächlich durch einen Enhancer, der sich 2,2 bis 2,7 bp …
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Expression and Regulation of Human Cytochrome P450 4F Isoforms In Tissue Samples and Under Tnf-Alpha Challenges
… that inflammatory cytokines, in particular TNF-α, play a role in regulating the expression of the CYP4F family. One of the isoforms, CYP4F11, had different characteristics than that of the other five CYP4F family members. CYP4F11 metabolizes xenobiotics while the other isoforms metabolize …
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Regulation of TNF-alpha gene expression by TNFAIP1 as an activator or suppressor in response to lipopolysaccharide
… the tumor necrosis factor induced protein 1(TNFAIP1) and TNF-alpha production in response to the P.gingivalis/LPS, and to investigate the mechanism that regulates the effect of the TNFAIP1 gene expression on TNF-alpha synthesis, using a new, simple, yet effective technique that allowed us to …
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Inflammatory Cytokine Mediated CNS Damage: Insights Into the Effects of Tnf-Alpha From a Neuronal Cell Line
… conditions in the CNS. Tumor necrosis factor-$\alpha$ (TNF) is an inflammatory cytokine that has been identified in directing neuronal response to disease or injury. Results are conflicting as to the role of TNF in mediating neuronal injury. TNF can protect neurons from excitotoxic and metabolic …
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TNF-[alpha] in host immunity to tuberculosis : in vivo and in vitro studies of protection and pathogenesis
Tuberculosis has been widespread from earliest history as demonstrated by skeletal deformities suggestive of spinal tuberculosis (Potts Disease) seen in Neolithic man (5000 BC) [Sager P, Schalimtzek M and Moller-Christensen V, 1972]. The earliest written reports similar of tuberculosis probably …
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Bestimmung von pH, pO2, TNF [alpha] und IL-6 in der peritonealen Drainageflüssigkeit zur Früherkennung einer postoperativen Anastomoseninsuffizienz
… interleukin [IL] -6 and tumor necrosis factor [TNF] Alpha) in postoperative peritoneal drainage fluid was studied over a seven day period, to prove whether these parameters were significant for early detection of an anastomotic leakage or not. In the investigated group all patients received …
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AIRWAY SURFACE HYPERVISCOSITY AND DEFECTIVE MUCOCILIARY TRANSPORT BY IL-17/TNF-ALPHA ARE CORRECTED BY BETA-ADRENERGIC STIMULUS
… We investigated the effects of IL-17A plus TNF-α, 2 cytokines with relevant roles in CF and other chronic lung diseases. Transcriptome analysis revealed a profound change with upregulation of several genes involved in ion transport, antibacterial defense, and neutrophil recruitment. At the …
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Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture
… that both nicotine and tumor necrosis factor-alpha have the ability to influence T cell receptor (TCR) signaling and the maturational capacity of treated cultures. FTOC treated with low concentrations of nicotine produced more immature T cells and fewer mature T cells. These expanded …
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Intramyokardiale Expression von COX-2 und TNF[alpha] in Abhängigkeit von der Kerntemperatur bei Herzoperationen mit extrakorporalem Kreislauf : eine tierexperimentelle Untersuchung
… leading to intramyocardial expression of TNFalpha and COX-2 using the pig model. Another focal point was further research concerning the effects of core temperature during the cardiopulmonary bypass on the expression of TNFalpha and COX-2 in the myocardium. 12 pigs were involved in the …
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Investigation of the effects of chinese herb medicine on TNF-[alpha] induced apoptosis in Huvec and Jurkat cells and their antioxidative effects
… viability. We found that PAC and PAL inhibited TNF-alpha induced apoptosis of human umbilical vein endothelial cells (Huvec) and Jurkat cells in a concentration of 100 µM and 1mM respectively, when applied 2 hours prior to TNF-alpha exposition. To investigate molecular consequences on cellular …
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Zeit- und konzentrationsabhängige Modulation der VEGF-Genexpression und der VEGF-Proteinmenge durch TNF[alpha] IL-1[beta], IL-6, EGF und TGF-[beta]1 in Ovarialkarzinomzellinien
… influence of the cytokines and growth factors TNF-alpha, IL-1beta, IL-6, EGF and TGF- beta 1 in regards to the VEGF- expression of the ovarian cancer cell lines BG-1, HEY and SKOV-3 by northern- analysis and ELISA. The stimulation with cytokines and growth factors resulted in minimal or not …
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