Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 127 for “"TNF-alpha"”.
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Effects of Liposome-Encapsulated TNF-Alpha and Radiation against Colon Cancer
… studies have shown that tumor necrosis factor-α (TNF-α) can augment the antitumor effects of radiation, inhibiting tumor progression to a greater extent than either modality alone. However, nonspecific toxicities associated with TNF-α have limited its use as an adjuvant. This limitation is …
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A Preclinical Model of Ionizing Radiation and TNF-alpha Gene Therapy for Cancer
… plasmid DNA expressing Tumor Necrosis Factor-α (TNF-α) could enhance the effect of ionizing radiation in an aggressive, rapidly growing glioma tumor (C6) model. Plasmid DNA is an attractive vector system for delivery of foreign genes into eukaryotic cells due to its advantages including low …
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Die Rolle des Tumorsuppressors p53 für die TNF-alpha-vermittelte Induktion des MCP-1-Gens
… Interleukin-1 (IL-1) und Tumor-Nekrose-Faktor-alpha (TNF-alpha). Das Gen, welches für MCP-1 codiert, ist ein "immediate-early" Gen. Die Induktion des MCP-1-Gens durch TNF-alpha wird auf der Ebene der Initiation der Transkription hauptsächlich durch einen Enhancer, der sich 2,2 bis 2,7 bp …
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Expression and Regulation of Human Cytochrome P450 4F Isoforms In Tissue Samples and Under Tnf-Alpha Challenges
… that inflammatory cytokines, in particular TNF-α, play a role in regulating the expression of the CYP4F family. One of the isoforms, CYP4F11, had different characteristics than that of the other five CYP4F family members. CYP4F11 metabolizes xenobiotics while the other isoforms metabolize …
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Regulation of TNF-alpha gene expression by TNFAIP1 as an activator or suppressor in response to lipopolysaccharide
… the tumor necrosis factor induced protein 1(TNFAIP1) and TNF-alpha production in response to the P.gingivalis/LPS, and to investigate the mechanism that regulates the effect of the TNFAIP1 gene expression on TNF-alpha synthesis, using a new, simple, yet effective technique that allowed us to …
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Inflammatory Cytokine Mediated CNS Damage: Insights Into the Effects of Tnf-Alpha From a Neuronal Cell Line
… conditions in the CNS. Tumor necrosis factor-$\alpha$ (TNF) is an inflammatory cytokine that has been identified in directing neuronal response to disease or injury. Results are conflicting as to the role of TNF in mediating neuronal injury. TNF can protect neurons from excitotoxic and metabolic …
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TNF-[alpha] in host immunity to tuberculosis : in vivo and in vitro studies of protection and pathogenesis
Tuberculosis has been widespread from earliest history as demonstrated by skeletal deformities suggestive of spinal tuberculosis (Potts Disease) seen in Neolithic man (5000 BC) [Sager P, Schalimtzek M and Moller-Christensen V, 1972]. The earliest written reports similar of tuberculosis probably …
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AIRWAY SURFACE HYPERVISCOSITY AND DEFECTIVE MUCOCILIARY TRANSPORT BY IL-17/TNF-ALPHA ARE CORRECTED BY BETA-ADRENERGIC STIMULUS
… We investigated the effects of IL-17A plus TNF-α, 2 cytokines with relevant roles in CF and other chronic lung diseases. Transcriptome analysis revealed a profound change with upregulation of several genes involved in ion transport, antibacterial defense, and neutrophil recruitment. At the …
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Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture
… that both nicotine and tumor necrosis factor-alpha have the ability to influence T cell receptor (TCR) signaling and the maturational capacity of treated cultures. FTOC treated with low concentrations of nicotine produced more immature T cells and fewer mature T cells. These expanded …
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Intestinal Inflammatory Responses to the Indigenous Microbiota
… the presence or absence of tumor necrosis factor-alpha (TNF-alpha). Co-culture of TNF-alpha-stimulated HT-29 cells with L. plantarum 299v increased interleukin-8. (IL-8) mRNA expression above levels observed for cells treated with TNF-alpha alone. The ability of TNF-alpha-to upregulate CD14 and …
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Preeclampsia, Autoimmunity and The At1 Receptor
… the autoantibody induced inflammatory cytokines. TNF-alpha, a potent pro-apoptotic cytokine, known to be increased in both the sera and placentas of preeclamptic women, was most elevated, and was therefore the focus of further research. When incubated with AT1-AA, human placental explants greatly …
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Regulation of ERK1/2 and SAPK/JNK Phosphorylation by Histamine
… played some role in this phosphorylation. Since TNF-alpha causes phosphorylation of ERK1/2, we investigated whether histamine acted via secretion of TNF-alpha to affect ERK1/2 phosphorylation. As a consequence, TNFalpha knockout mice were used and we found that TNF-alpha was involved in ERK2 …
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The effects of two modes of exercise training on plasma biomarkers of inflammation and oxidative stress in patients with symptomatic peripheral artery disease
… and oxidative stress. Analysis of plasma for TNF alpha, IL-10, and F2 Isoprostane were performed at baseline and following 12 weeks of moderate intensity, claudication inducing treadmill training (T), upper body ergometry training (UBE), or usual care (C). Analysis of covariance was used to …
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Nanoparticle preconditioning for enhanced thermal therapies in cancer.
… tagged with a vascular targeting agent (TNF-alpha). In addition, mechanistic studies have shown that 4 hour pre-treatment with native TNF-alpha induced vascular preconditioning including the up regulation of inflammation (NF-kappaB) and apoptotic (caspase) pathways accompanied by an …
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On the role of mast cells in chemokine-induced leukocyte recruitment
… wide spectrum of inflammatory mediators, such as TNF-alpha and chemokines. Chemokines are effective leukocyte attractants and according to structural properties, chemokines are divided into two major subfamilies, CC and CXC. In general, CC chemokines exert chemotactic influence on monocytes and …
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Mechanismen der Apoptose in proximalen Tubulusepithelzellen der Niere (LLC-PK1) : ein pathophysiologisches Modell für das hämolytisch-urämische Syndrom (HUS)
… nachgewiesen werden. Es ist bekannt, daß TNF-alpha; die Expression von Gb3-Rezeptoren auf Endothelzellen steigert und dadurch die Shigatoxinwirkung verstärkt. Auf LLC-PK1-Zellen (Epithelzellen) dagegen steigerte die Vorbehandlung mit TNF-alpha (10ng/ml) die Gb3-Rezeptorexpression nur …
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Inflammatory markers as novel predictors of cardiovascular disease
… inflammatory markers (tumour necrosis factor alpha [TNF alpha], IL-18, soluble CD40 ligand [sCD40L], and matrix metalloproteinase-9 [MMP-9]) are associated with classical cardiovascular risk factors, and with future CVD events in several epidemiological studies. In studies of pre-analytical …
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Einfluss von HLA-G und HLA-E exprimierenden K-562 Zellen auf in-vitro kultivierte humane dendritische Zellen
… der Zytokine IL-10, IL-12p70, IL-18 und TNF-alpha sowie des Chemokins IL-8 im Überstand mit ELISA bestimmt. Ergebnisse. Die Kultur mit nicht transfizierten K-562 Zellen resultierte in einem signifikanten Anstieg der Produktion von IL-8 und TNF-alpha durch unreife und reife DC sowie von …
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