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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 107 for “"TNF-a"”.

  1. Calpain 9 Functions in TNF Receptor Mediated Apoptosis

    Kunkel, Gregory Thomas2012

    … sensitivity through activation of autocrine TNF-a secretion and TNF dependent apoptosis. Using Smac mimetic sensitivity as a model system, I performed a genome-wide high-throughput siRNA screen and identified Calpain 9, CAPN9, as a novel component of TNF-alpha induced apoptosis. CAPN9 …

    utswmed Repository record

  2. Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells

    Rakesh, KritiCreighton University2007

    … to both IGF-i and tumor necrosis factor (TNF)-a, in human coronary artery smooth muscle cells. I also found that SOCS3 inhibits cell proliferation mediated by IGF-i. However, its role in the regulation of smooth muscle cell proliferation in presence of growth factors and cytokines is not …

    creighton Repository record

  3. Cell-surface Tumoricidal Molecules and NF-kB in the Tumor-burdened Host

    McConnell, Michael JamesVirginia Tech2002

    … microenvironment. Tumor necrosis factor (TNF)-a is both secreted by and expressed on the cell-surface (mTNF-a) of macrophages. When stimulated with LPS, tumor-burdened host (TBH) macrophages secrete more TNF-a than normal host (NH) macrophages. In this study, I showed that mTNF-a is …

    vt Repository record

  4. Biochemical Studies on Uncoupling Proteins and Glucose Metabolism in Skeletal Muscle

    El-Ella, Ghada AbouCreighton University2002

    … utilization. The reported involvement of TNF-a and IL-ip in the pathogenesis of cachexia and insulin resistance triggered investigation of the effect of these inflammatory cytokines on the expression of the UCPs in skeletal muscle cells. TNF-a and IL-ip induced an increase in the …

    creighton Repository record

  5. Periventricular white matter damage in the post-natal brain in hypoxic conditions

    DENG YIYU2009

    … which upregulated tumor necrosis factor-a (TNF-a), interleukin-1ß (IL-1ß), monocyte chemoattractant protein-1 (MCP-1), chemokine (C-C motif) receptor 2 (CCR2), and macrophage-colony stimulating factor (M-CSF) expression was observed. Immunoexpression of these was specifically located in AMC …

    nus Repository record

  6. Untersuchungen zur dynamischen Regulation der Interaktion von RGS7 mit dem Adapterprotein 14-3-3

    Johnsen, Marc

    … der Sepsis auftretende Immunmodulator TNF-a, der auch bei der Ubiquitin-Proteasom-abhängigen Degradation von RGS7 eine Rolle spielt. Da TNF-a über die Inhibition der Degradation zur Heraufregulation von RGS7 führt, erschien die Frage besonders interessant, ob TNF-a auch die …

    freiburg-diss Repository record

  7. Untersuchungen über die Interaktion von Meningokokken mit Zellen der Blut-Hirn-Schranke

    Jaegerhuber, RuthLudwig-Maximilians-Universität

    … die Freisetzung von Tumornekrosefaktor alpha (TNF-a), Interleukin-1b (IL-1b), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Monocyten-attrahierendem Protein-1 (MCP-1) und transformierendem Wachstumsfaktor beta (TGF-b) durch Gehirnendothelzellen nach Infektion mit Meningokokken analysiert. Mit …

    lmu-germany Repository record

  8. The incidence of tuberculosis in the inflammatory bowel disease registry in Cape Town, South Africa

    Pema, Mitesh KanthiDepartment of Medicine2021

    … the study population and for cases prescribed TNF-a (tumour necrosis factor-alpha) blockers. A multivariable logistic regression model, using non-TB IBD patients as controls, was applied to determine risk factors for infection. We analysed IBD and TB clinical features as well as screening tests …

    cape-town Repository record

  9. Determination of Tumor Necrosis factor-a, Interluekin-10, Interluekin-12, and Intercellular adhesion molecule-1 levels in relation to Malaria severity in children

    Sitali, Lungowe2012

    … of malaria. Potential associations between TNF-a, IL-10, IL-12 and ICAM-1 and malaria disease severity were investigated in the study. Children of ages 12 to 144 months presenting with severe or uncomplicated malaria were assessed as regards to the respective serum cytokine levels at …

    zimbabwe Repository record

  10. Determination of Tumor Necrosis factor-a, Interluekin-10, Interluekin-12, and Intercellular adhesion molecule-1 levels in relation to Malaria severity in children

    Sitali, Lungowe2012

    … of malaria. Potential associations between TNF-a, IL-10, IL-12 and ICAM-1 and malaria disease severity were investigated in the study. Children of ages 12 to 144 months presenting with severe or uncomplicated malaria were assessed as regards to the respective serum cytokine levels at …

    zambia Repository record

  11. Der Einfluss von HLA-G und HLA-E auf Large Granular Lymphocytes

    Probe, ChristineUniversität Würzburg

    … wurde die Expression der Sekretion der Zytokine TNF-a, IFN-g, GM-CSF, IL-5, IL-10, IL-13 und IL-15 gemessen. Dabei zeigte die Chorionkarzinomzelllinie JEG-3 eine Unterdrückung der TNF-a-, IFN-g-, GM-CSF- und IL-13-Produktion, aber eine Erhöhung der IL-10- und IL-15-Produktion gegenüber JAR. …

    wurz-thes Repository record

  12. Beeinflussung der Aktivität von NF-kappaB durch gram-negative Bakterien - ein Beitrag zur Pathogenese der reaktiven Arthritis

    Greil, SabineUniversität Würzburg

    … Darmbakterien und weiteren Erregern. TNF-a spielt eine wichtige Rolle bei der Erregerantwort der infizierten Zellen, in welchen erhöhte TNF-a-Titer gemessen wurden. Das bekannte Mitwirken von NF-kB in immunologischen Prozessen ließ vermuten, dass dieser Transkriptionsfaktor an der …

    wurz-thes Repository record

  13. A study of the immune response in murine experimental malaria, with special reference to the effects of South African medicinal plants, artesunate and chloroquine

    Gumede, BonginkosiDivision of Clinical Pharmacology2003

    The role of pro-inflarrnnatory cytokines (TNF and IFN-y) in a murine experimental malaria model for cerebral malaria is reported in this thesis. Wild type and receptor knockout mice (IFN-y deficient mice (IFN-l") and TNF-a/fr1- double deficient) were infected with Plasmodium berghei ANKA {PbA). PbA …

    cape-town Repository record

  14. Untersuchung zur Phagozytose eosinophiler Granulozyten durch Makrophagen unter Zytokineinfluss

    Zerweck, Claudia

    … mit den aktivierenden Zytokinen IFN-g und TNF-a zu einer signifikanten Zunahme der Phagozytosekapazität für apoptotische eosinophile Granulozyten führte, wobei TNF-a einen stärkeren Anstieg der Zahl an eosinophilenhaltigen Makrophagen erbrachte. Am ausgeprägtesten zeigte sich dieser Effekt …

    freiburg-diss Repository record

  15. Development of screening assays to test novel integrin antagonists in allergic inflammation

    Spartà, Antonino Maria <1977>Alma Mater Studiorum - Università di Bologna2009

    … Jurkat E6.1 cells. Analyzing the supernatant of TNF-a-treated (24h) eosinophilic cells (EoL-1), we report that levocabastine reduces the TNF-a-induced release of the cytokines IL-12p40, IL-8 and VEGF. Finally, in a model of allergic conjunctivitis, levocastine eye drops (0.05%) reduced the …

    bologna Repository record

  16. Untersuchungen zur Rolle des HIV-1-Tat-Proteins in der AIDS-assoziierten Vaskulopathie

    Matzen, KathrinLudwig-Maximilians-Universität

    … und das inflammatorische Zytokin TNF-a synergistisch die Adhäsion der promonozytären Zelllinie U937 und von PBMZ an humane mikrovaskuläre Endothelzellen (HMVEZ) erhöht. Die adhäsionsfördernde Wirkung wurde selektiv bei HIV-1-Tat beobachtet, andere virale Proteine des HIV-1, wie …

    lmu-germany Repository record

  17. Mechanismen der CD8+ T-Zell-vermittelten Tumorabwehr beim B16 Melanom der Maus

    Neuenhahn, Michael

    … aus Perforin (P°)-, Interferon-g (IFN°)-, und TNF-a (TNF°)-defizienten TCR tg Mäusen in Mäuse mit etablierten Metastasen transferiert. Während nach Transfer von TCR tg-P° und TCR tg-TNF° T-Effektorzellen sowohl in immunkompetenten als auch in Perforin- bzw. TNF-a-defizienten Empfängermäusen …

    freiburg-diss Repository record

  18. Phytochemische und pharmakologisch-biologische Untersuchungen von Mikania cordifolia sowie Studien zum molekularen Wirkmechanismus von Sesquiterpenlactonen unter Verwendung des Transkriptionsfaktors NF-AT

    Klaas, Christoph

    … die Freisetzung der Zytokine IL-1b, IL-6 und TNF-a sowie die Proliferation von T- und B-Lymphozyten gehemmt wurde. <br>Mit den Sesquiterpenlactonen Parthenolid und 4ß,15-Epoxymiller-9E-enolid wurden Experimente zum Wirkungsmechanismus der NF-AT/AP-1-Hemmung durchgeführt. Es konnte gezeigt …

    freiburg-diss Repository record

  19. Regulation of Tumor Necrosis Factor-alpha Signaling in Rheumatoid Arthritis Synovial Fibroblasts by Green Tea Polyphenol Epigallocatechin-3-gallate

    Riegsecker, SharayahUniversity of Toledo Health Science Campus2013

    … interleukin (IL)-1β and tumor necrosis factor (TNF)-α, stimulate synovial fibroblast proliferation leading to joint damage and destruction. Epigallocatechin-3-gallate (EGCG) is a polyphenol found in green tea that has been shown to have an anti-inflammatory effect in RA. Previous studies suggest …

    ohiolink Repository record

  20. The Effects of Long Term Walnut Consumption on Levels of Plasma Tocopherols and Inflammatory Mediators

    Sapwarobol, Suwimol

    … interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and Creactive protein (CRP) in healthy participants. Ninety participants were recruited into a 12-month randomized crossover intervention study, which consisted of two phases, the walnut supplemented diet and the habitual diet. Participants …

    loma-linda Repository record

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