Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 429 for “"TNF-α"”.
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Fumarate Inhibits TNF-α Release
… respond by releasing tumor necrosis factor-α (TNF-α). While beneficial for neutralizing acute pathogen exposure, prolonged TNF-α release results in chronic inflammation and tissue damage. In the present study, we examined two methylated derivatives of a citric acid cycle intermediate, fumarate, …
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The role of TNF α gas in cardiac protection
Bibliography: leaves 76-87.
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Mechanism of TNF-α cytotoxicity in a leukemia virus transformation model
… to determine whether cells not sensitive to TNF-α could be made sensitive to the cytolytic action of TNF-α when infected with this retrovirus. Mouse embryonic fibroblast cell line CL.7 was found to be relatively insensitive to TNF-α. Upon transformation with A-MuLV, these cells gave rise to a …
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Studies of TNF- α-induced -GSIS Inhibition in INS-1 β-cell
… of type Ⅱ Diabetes. It has been reported that TNF-α, proinflammatory cytokine, was increased in obese type Ⅱ Diabetes states and it inhibits GSIS in INS-1 β-cell. This mechanism has not been examined in detail. So we investigated the mechanism which TNF-α inhibits GSIS in INS-1 β-cell. RESULT: …
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The Mechanism and Effects of TNF-α on Apoptosis in Auditory Cell Line
TNF-α is released in a variety of pathological states in the inner ear. Inducible NO synthase (iNOS) can be induced by cytokines and other inflammatory factors, and is generally thought to be associated with inflammation and other pathological processes in the cochlea. The purpose of the present …
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Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis
… others have previously reported members of the TNF receptor super-family as substrates for γ-secretase proteolysis, and that presenilin-deficient cells have increased resistance to TNFα-induced apoptosis. In this study, we sought to determine whether loss of presenilin expression or loss of …
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Variable Tnf-α Production By Murine Macrophages to a Cell Wall Extract of Candida Albicans
… inflammatory cytokine, tumor necrosis factor α (TNF-α). Since mannan is a component of the fungal cell wall that has been indentified as an important virulence factor in the pathogenicity of C. albicans, we examined its ability to stimulate macrophages to produce TNF-α. Mannan was extracted from …
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The Effect of Storage on Activity of Murine Tnf-α: a Comparison of Inbred and Outbred Strains
… antigenic challenge release the potent cytokine, TNF-α, which initiates inflammationa and possible septic shock. Inbred strains are the preferred odel to study macrophage production of TNF-α because they are genetically homogeneous. The dimorphic yeast, Candida albicans, is an opportunistic …
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Measuring the Changes in Tumor Necrosis Factor-Alpha (TNF-α) from Secretory Populations of U937 Monocytic Cells during Differentiation.
<p>Tumor necrosis factor-alpha (TNF-α) is a cytokine produced primarily by macrophages during acute inflammation. In this study we examined the differential effect of retinoic acid (RA) and phorbol 12-myristate 13-acetate (PMA) on the induction of TNF-α secretion from U937 monocytic cell …
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Studies on the production of IL-1β, TNF-α, iNOS, IL-10, and ROS in the APP/PS1 mouse model of Alzheimer's disease
… activated. The mRNA and protein levels of IL-1β, TNF-α and iNOS were detected from 3 months, and they were increased with age. The mRNA and protein levels of IL-10 were detectable in 6 month-old transgenic mouse, which is 3 months later than the expression of pro-inflammatory mediators. Double …
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Changes in Pancreatic and Jejunal Histopatholgy and Serum IFN-γ, TNF-α Levels in Type 1 Diabetes: Role of Chloroform Methanol Soluble Gliadin Proteins
… in jejunal histopathology and sera IFN-γ, TNF-α cytokine concentration in type 1 diabetes, induced by GSLEE. A decrease in jejunal CD4+ and γδ TCR + cell counts and inflammatory cell infiltrate were observed due to presence of CM soluble GSLEE in the HC diet, although this decrease was not …
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Effects of Liposome-Encapsulated TNF-Alpha and Radiation against Colon Cancer
… studies have shown that tumor necrosis factor-α (TNF-α) can augment the antitumor effects of radiation, inhibiting tumor progression to a greater extent than either modality alone. However, nonspecific toxicities associated with TNF-α have limited its use as an adjuvant. This limitation is …
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Níveis plasmáticos de liqüoricos de interleucina-6 e fator de necrose tumora-alfa em recém nascidos a termo com encefalopatia hipóxico-isquêmica
… os níveis plasmáticos e liqüóricos de IL-6 e TNF-α em recém- -nascidos a termo com Encefalopatia hipóxico-isquêmica (EHI), comparando-os com recém- -nascidos a termo sépticos sem meningite e sem EHI e com recém-nascidos controles. Método: Foi realizado um estudo de caso-controle com três …
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Gradiente imunoinflamatório sérico em pacientes com insuficiência cardíaca avançada
… anos). Foram analisadas as concentrações de TNF-α, seus receptores solúveis I e II, da interleucina 6 e do receptor solúvel da interleucina 2 pelo método de ELISA no sangue periférico e sangue do seio coronário de todos os indivíduos. Resultados - Nos pacientes, as concentrações periféricas …
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The Effect of Adenosine on the Production of Inflammatory Mediators By Macrophages in Response to Candida Albicans
… the cytokines tumor necrosis factor alpha (TNF-α) and interleukin 1 (IL-1). Adenosine is an important physiological molecule that can modulate the function of macrophages by altering the amounts of cytokine produced. The effect of adenosine on the production of TNF-α and IL-1 by peritoneal …
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Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases
… various cytokines, particularly IFN-γ and TNF-α, produced by activated immune cells, play a significant role in the pathogenesis of IBD. TNF-α blocking antibodies, known collectively as anti-TNFs, revolutionised the treatment of IBD in the mid to late 1990s; however, about 60% of patients …
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The role of the rho-associated coiled-coil containing kinase (ROCK) in cytokine-induced chemokine responses in intestinal epithelial cells
… can cause severe tissue damage and even death. TNF-α is a pro-inflammatory cytokine that is elevated in IBD and plays a central role in inflammation. Previous results in our laboratory showed that another cytokine, IL-1β, induces chemokine expression in intestinal epithelial cells (IEC), which …
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The production and gene polymorphisms of tumor necrosis factor-alpha in patients with tuberculosis in the Vhembe District, Limpopo Province
… assess the production and gene polymorphisms of TNF-α in patients with TB in the Vhembe district, Limpopo province. Methods: This study recruited thirteen TB patients from three healthcare facilities in the Vhembe district, Limpopo province. Collected samples (sputum) were analysed using the …
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