Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"TNF superfamily"”.
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Immunogenetic Study of Autoimmunity-Associated Variants in Selected TNF Superfamily Genes
… to or intronic within genes involved in LIGHT (TNFSF14) signalling. To establish the settings in which these SNPs regulate gene expression, I first recruited healthy volunteers that are heterozygous for my SNPs of interest and assayed Allele Specific Expression (ASE) under different activation …
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Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases
… various cytokines, particularly IFN-γ and TNF-α, produced by activated immune cells, play a significant role in the pathogenesis of IBD. TNF-α blocking antibodies, known collectively as anti-TNFs, revolutionised the treatment of IBD in the mid to late 1990s; however, about 60% of patients …
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Mechanisms of TRAF Signaling
… transduction activated by tumor necrosis factor (TNF) superfamily proteins. Ligands of the TNF family engage TNF receptor (TNFR) family proteins, leading to a wide variety of cellular effects, these interactions are implicated in inflammation, immune regulation, bone homeostasis, and development. …
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Estrogen Inducible Proteinase Inhibitor 9 Protects Target Cells From Immune Surveillance and Apoptosis
… PI-9 to inhibit cytotoxocity by members of the TNF superfamily. To test the effect of the selective estrogen receptor modulator (SERM), 4-hydroxytamoxifen (OHT) (the active metabolite of tamoxifen), we used a tet-inducible MCF-7 cell model system, termed MCF7ERalphaHA cells. In MCF7ERalphaHA …
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The Tumor-Suppressive Properties of Neural Stem Cells
… increased expression of tumor necrosis factor (TNF) superfamily death receptor ligands by the NSCs. NSCs also were found to express many immune-related cytokines and chemokines involved in immune signaling, suggesting a potential role in mediating anti-tumor immune responses. These results …
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TL1A Priming Induces a Multi-Cytokine Th9 Cell Phenotype That Promotes Robust Allergic Inflammation in Murine Models of Asthma
The TNF superfamily member TL1A is a costimulatory molecule that signals through its receptor DR3 on T lymphocytes. The Th9 subset of T lymphocytes secretes the pleiotropic cytokine IL-9 which has functions in allergic airway disease, helminth infections, and tumor immunity. TL1A increases IL-9 …
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Targeting Traf6 For Cancer Therapeutical Development
<p>Tumor necrosis factor (TNF)-Receptor Associated Factors (TRAFs) are a family of signal transducer proteins. TRAF6 is a unique member of this family in that it is involved in not only the TNF superfamily, but the toll-like receptor (TLR)/IL-1R (TIR) superfamily. The formation of the complex …
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TRAIL and TGF-ßl-Induced Apoptosis of Human Airway Epithelial Cells
… is not well defined. A new member of the TNF superfamily, TRAIL, is predominantly involved in apoptosis. Various studies in hepatoma cells have linked the pathways of TRAIL and TGF-ßl. Given this information, we hypothesized that TGF-ßl induced apoptosis of airway epithelial cells occurs …
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Targeting TNFSF10 as a novel immunotherapeutic strategy in Alzheimer’s disease
… Apoptosis-Inducing Ligand (TRAIL), also named as TNFSF10, a cytokine belonging to the TNF superfamily, involved in the pathogenesis of several disorders and, in particular, in the AD-related inflammatory processes. Taking into account such hypothesized prominent role of immune response in AD, a …