Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"TNF inhibitors"”.
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TNF inhibitors for the prevention of Alzheimer’s disease
… diseases including tumour necrosis factor-alpha (TNFa), a proinflammatory cytokine which has been associated with an increased rate of neurodegeneration and risk of conversion from mild cognitive impairment (MCI) to AD dementia. This led to the development of a hypothesis which suggested that …
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Outcomes of Immune Checkpoint Inhibitor-Mediated Colitis: Multicenter Cohort Study
… length of corticosteroid therapy was 52 days. TNF inhibitors were given to 244 patients (36.2%). Ninety patients (13.4%) received vedolizumab. After resolution of symptoms, 201 patients (29.8%) had recurrent IMC. Predictors of IMC recurrence were days of hospitalization (P=0.003) , grade 4 IMC …
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The Role of TNF Signaling in Regulating Beta-Amyloid Burden in the 3xTgAD Mouse Model of Alzheimer's Disease
… pro-inflammatory cytokine Tumor Necrosis Factor (TNF) has been implicated in AD by its elevated presence in serum and post-mortem brains of patients with AD. To test the hypothesis that TNF-dependent neuroinflammation and neurotoxicity contributes to the increased microglial burden and exacerbated …
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Noncanonical NF-KB in Gastrointestinal Disease
… in patients that have lost response to anti-TNF inhibitors, which are potent drugs that are widely used to treat IBD. In Chapter 5 we focus on NIK and its effects on stem cell function, growth, and inflammation-induced cancer in the gut. Loss of NIK in mice results in alterations in colonic …
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A retrospective study of patients with biologics treatment at Groote Schuur and Red Cross Children's War Memorial Hospitals
… SLE, 7 other conditions). The bDMARDs used were TNF inhibitors (112), rituximab (55), tocilizumab (10), anakinra (3), abatacept (1), and tofacitinib (1). The vast majority of patients had an excellent response and were in low disease activity or remission at their last available visit. Adverse …
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Dendritic Cells in Normal and Inflamed Human Skin
… epidermis. Recent studies, however, show that inhibitors of tumor necrosis factor (TNF) are also effective therapeutics. Activated dendritic cells (DCs) produce large ammounts of TNF which acts in an autocrine loop to increase DC maturation. Thus, TNF inhibitors may inhibit DC maturation and …