Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 185 for “"TNFα"”.
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Role of nuclear factors kappa-B in TNFα-induced cytoprotection
Includes bibliographical references (leaves 67-81).
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Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species
Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely …
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Lipid raft signaling in cofilin-actin rod formation induced by amyloid-β and TNFα
… then showed that the proinflammatory cytokine (TNFα) induced about a 3 fold increase in rod formation over untreated controls quantified either as the percent of neurons with rods (percent rod index) or as the number of rods per field (number rod index). Amyloid beta dimer/trimer (Aβd/t) induced …
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Purification of SIMPL Antibody and Immunofluorescence of SIMPL Sub-Cellular Localization in Response to TNFα- and IL-1
SIMPL is a transcriptional co-activator that alters the activity of transcription factor, NF-κB. In response to pathogens, cytokines such as Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) signal through the IL-1 and TNF-α receptors, respectively, which are found on various cell types. …
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Wirkung der proinflammatorischen Zytokine TNFα und IL-1β auf die Aktivität und die Proteinmenge der Dual-Leucine-Zipper-Bearing Kinase in einer Betazelllinie
… Die proinflammatorischen Zytokine TNFα und IL-1β sind dabei wichtige pathogene Effektoren, wobei die Signaltransduktion, über die sie auf die Betazellen wirken, noch nicht vollständig geklärt ist. Die MAP3K DLK ist eine wichtige Komponente in der Regulation des programmierten …
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The protective role of tumour necrosis factor alpha in the heart
… cytokine tumour necrosis factor alpha (TNFα) is produced by the heart in response to the ischaemic preconditioning (PC) stimulus. We hypothesised that this endogenously produced peptide may play a role in activating the ischaemic PC mediated tolerance towards a subsequent ischaemic …
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The role of signal regulatory protein alpha in regulating macrophage subset activity in homeostasis and inflammation
… extends to negative regulation of TLR-mediated TNFα production, and how this differs between Mφ subsets and under various TNFα-inducing stimuli. SIRPα and CD47 expression in THP-1-derived M1- and M2-like Mφs, HL-60 pro-myelocytes and K562 lymphoblasts was measured using flow cytometry. THP-1 …
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Targeting pro-inflammatory mediators to treat visceral pain
… I observed that mast-cell derived cytokines (TNFα & IL-4), lipids (PGD2 & LTC4) and growth factors (NGF & SCF) all increased [Ca2+]i in distinct populations of DRG neurons, the majority of which also responded to the TRPV1 agonist capsaicin, thus indicating that these neurons were nociceptors. …
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The role of the chromatin protein HMGN3 in cytokine induced gene expression
… HMGN3 transcript. HMGN3 was shown to regulate TNFα-induced expression of the murine chemokine gene CCL1 which is implicated in conditions such as asthma, atherosclerosis and cancer. However, the mechanism by which HMGN3 modulates gene expression was unknown. This investigation studied the role …
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Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis
… cells have increased resistance to TNFα-induced apoptosis. In this study, we sought to determine whether loss of presenilin expression or loss of γ-secretase protease activity is associated with increased resistance to TNFα-induced apoptosis. Utilizing the cleavage of caspase 3 and …
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Directed Migration Achieved in Mammalian Cells via Ca2+ Signal Rewiring in Synthetic Protein Chimeras
… systems, i.e., inflammatory cytokines such as TNFα and antibodies. A system of proteins was used: an engineered TNFα chimeric receptor (named TNFR1chi), a previously engineered Ca2+-activated RhoA (named CaRQ), VSVG and thymidine kinase. Upon binding TNFα, TNFR1chi generates a Ca2+ signal that …
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Investigating the efficacy and mechanism of action of mesenchymal stromal cell therapy in burn wound healing
… was explored. Administration of MSC primed with TNFα resulted in a significant acceleration of burn wound closure, re-epithelialisation and increased angiogenesis, AD-MSC and BM-MSC were therapeutically equivalent in their response to TNFα. We hypothesised that MSC derived CCL-2 may be involved …
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Pre-clinical evaluation of inhibitors of apoptosis protein (IAP) antagonists in colorectal cancer
… tumour microenvironment in which TNFα signalling plays an important role. Inhibitor of apoptosis proteins (IAPs) are capable of converting TNFα signalling from a pro-apoptotic to a pro-survival and pro-inflammatory signal. Overexpression of IAPs is associated with chemoresistance …
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Dynamic Characterization of the IKK:κBα:NFκB Negative Feedback Loop Using Real-Time Bioluminescence Imaging
… dynamic patterns in response to modulation of TNFα; concentration or pulse duration, and that responses to TNFα exhibited a remarkable degree of synchronicity at the level of single cells, cell populations, and in vivo. Furthermore, we discovered a TNFα-induced transient refractory period …
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… ligands, such as tumour necrosis factor alpha (TNFα). I hypothesize that type I interferon (IFN) stimulation in cancer cells and in immune cells leads to the production of TNFα, which can then synergize with SMCs to kill cancer cells. The combined treatment of SMC and IFNα induces tumour …
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Characterizing the pro-inflammatory cytokine response by dendritic cells upon exposure to PrP proteins
… exposure of PrPSc on DC activation by measuring TNFα and IL-12 production. There was no significant production of TNFα or IL-12 by bone marrow derived DCs (BMDC) after exposure to PrPSc infected brain homogenate, however, BMDCs had lower capacity to produce IL-12 after secondary stimulation with …
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Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia
… of proinflammatory cytokines (IL-1β, IL-6, TNFα) on three species common in VAP: Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa. The ability of these cytokines to influence growth, biofilm formation, antimicrobial sensitivity, and rate of antibiotic adaptation was …
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Investigation of differential TNFα-induced interleukin-6 gene regulation by synthesis progestins medroxyprogesterone acetate (MPA) and norethindrone acetate (NET-A) in human endocervical epithelial cells and the role of the unliganded glucocorticoid receptor
The endocervical mucosae of the female reproductive tract (FRT) not only serve as a physical barrier against microbial infection, but they also express a wide variety of immune mediators. The endocervical epithelial cells express a distinct profile of immune-regulators, which is higher than vaginal …
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