Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 958 for “"TNF"”.
-
Fumarate Inhibits TNF-α Release
… respond by releasing tumor necrosis factor-α (TNF-α). While beneficial for neutralizing acute pathogen exposure, prolonged TNF-α release results in chronic inflammation and tissue damage. In the present study, we examined two methylated derivatives of a citric acid cycle intermediate, fumarate, …
-
Calpain 9 Functions in TNF Receptor Mediated Apoptosis
… sensitivity through activation of autocrine TNF-a secretion and TNF dependent apoptosis. Using Smac mimetic sensitivity as a model system, I performed a genome-wide high-throughput siRNA screen and identified Calpain 9, CAPN9, as a novel component of TNF-alpha induced apoptosis. CAPN9 …
-
TNF inhibitors for the prevention of Alzheimer’s disease
… diseases including tumour necrosis factor-alpha (TNFa), a proinflammatory cytokine which has been associated with an increased rate of neurodegeneration and risk of conversion from mild cognitive impairment (MCI) to AD dementia. This led to the development of a hypothesis which suggested that …
-
Investigating the Role of Pellin03 in TNF Signalling
Tumor necrosis factor (TNF) is an important modulator of the innate immune system, responsible for the activation of immune cells as well as the removal of damaged cells. Aberrant TNF signalling can cause a number of pathologic conditions. TNF binding to TNF receptor 1 triggers the activation of …
-
Diseased Thyrocytes Have Aberrant Communication and TNF Receptor Secretion
… including Tumor Necrosis Factor-<em>alpha</em> (TNF- α).</p> <p>We have used thyroiditis as our model of autoimmunity and have documented the development of spontaneous thyroiditis in MRL-lpr/lpr mice. We have found aberrant connexin expression in thyroid tissue from these mice. The abnormal gap …
-
The role of TNF α gas in cardiac protection
Bibliography: leaves 76-87.
-
Tnf Signaling During Tissue Damage-Induced Nociceptive Sensitization In Drosophila
<p>Tumor necrosis factor (TNF) signaling is required for inflammatory nociceptive sensitization in both <em>Drosophila</em> and vertebrates. In <em>Drosophila</em> larval model of nociceptive sensitization, UV irradiation in results in epidermal apoptosis and thermal allodynia. TNF/Eiger is …
-
Optimizing immunomodulator and anti-TNF treatment in Inflammatory Bowel Diseases.
Contains fulltext : 297656.pdf (Publisher’s version ) (Open Access)
-
Functional implications of TNF-receptor pathways on regulatory T cells
Contains fulltext : 112919.pdf (Publisher’s version ) (Open Access)
-
Personalized medicine in rheumatoid arthritis: Pharmacogenetics of anti-TNF and beyond.
Contains fulltext : 129676.pdf (Publisher’s version ) (Open Access)
-
Effects of Liposome-Encapsulated TNF-Alpha and Radiation against Colon Cancer
… studies have shown that tumor necrosis factor-α (TNF-α) can augment the antitumor effects of radiation, inhibiting tumor progression to a greater extent than either modality alone. However, nonspecific toxicities associated with TNF-α have limited its use as an adjuvant. This limitation is …
-
Immunogenetic Study of Autoimmunity-Associated Variants in Selected TNF Superfamily Genes
… to or intronic within genes involved in LIGHT (TNFSF14) signalling. To establish the settings in which these SNPs regulate gene expression, I first recruited healthy volunteers that are heterozygous for my SNPs of interest and assayed Allele Specific Expression (ASE) under different activation …
-
Mechanism of TNF-α cytotoxicity in a leukemia virus transformation model
… to determine whether cells not sensitive to TNF-α could be made sensitive to the cytolytic action of TNF-α when infected with this retrovirus. Mouse embryonic fibroblast cell line CL.7 was found to be relatively insensitive to TNF-α. Upon transformation with A-MuLV, these cells gave rise to a …
-
Progresión radiográfica en pacientes con Espondiloartritis Axial en tratamiento con anti-TNF
Contexto: La eficacia clínica de los anti-TNF en la espondiloartritis axial (EspAax) ha sido ampliamente demostrada en ensayos clínicos aleatorizados. Algunos estudios observacionales sugieren que el tratamiento a largo plazo con anti-TNF (más de 4 años) podrían ralentizar la progresión …
-
Studies of TNF- α-induced -GSIS Inhibition in INS-1 β-cell
… of type Ⅱ Diabetes. It has been reported that TNF-α, proinflammatory cytokine, was increased in obese type Ⅱ Diabetes states and it inhibits GSIS in INS-1 β-cell. This mechanism has not been examined in detail. So we investigated the mechanism which TNF-α inhibits GSIS in INS-1 β-cell. RESULT: …
-
A Preclinical Model of Ionizing Radiation and TNF-alpha Gene Therapy for Cancer
… plasmid DNA expressing Tumor Necrosis Factor-α (TNF-α) could enhance the effect of ionizing radiation in an aggressive, rapidly growing glioma tumor (C6) model. Plasmid DNA is an attractive vector system for delivery of foreign genes into eukaryotic cells due to its advantages including low …
-
The role of TNFAIP1 in regulation of LPS/TNF-ɑ-induced signaling pathway
… via stimulation of some cytokines such as TNF-ɑ. TNF-ɑ can activate expression of early response genes in macrophages, including Tumor Necrosis Factor-?-Induced Protein 1 (TNFAIP1). However, the role of TNFAIP1 in LPS-induced inflammation is largely unknown. OBJECTIVE: 1. Identification of …
Page 1 of 48