Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"TMZ"”.
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Drug delivery systems to include liposomes and microparticles in order to aid treatment of glioma.
… out to investigate the effect of encapsulating TMZ and Patrin-2 into liposomes and microparticles separately in order to enhance the delivery. A validated HPLC system was used for the analysis of both TMZ and Patrin-2. First phase of our study involved the preparation of a delivery system of TMZ …
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Targeting DNA Double-Strand Break Repair to Potentiate Radio- and Chemo Therapy of Glioblastoma
… followed by radiation and adjuvant temozolomide (TMZ) is the standard of care for glioblastoma (GBM). Not all GBMs respond to therapy, and most of them quickly acquire resistance to TMZ and recur. In order to develop more effective and rational treatments for GBM, it is crucial to understand the …
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DLL4 and JAG1 in the Glioblastoma Response to Temozolomide Chemotherapy
… by radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. Prognosis is poor, with a median survival of 14.6 months following diagnosis. Treatment often fails due to intrinsic or acquired TMZ resistance of a small population of cells termed glioma cancer stem cells (GCSCs). A promising …
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EVALUATING THE EFFECTS OF FASTING CONDITIONS IN COMBINATION WITH TEMOZOLOMIDE FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME
… with the chemotherapeutic agent temozolomide (TMZ) and radiotherapy. O-6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein involved in TMZ resistance. Known as the Warburg effect, cancer cells will preferentially oxidize glucose to lactate in glycolysis. This less effective …
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Mechanism of acquired temozolomide resistance in glioblastoma
… We isolated GBM cells resistant to temozolomide (TMZ), the frontline chemotherapy agent for GBM, and observed modest decreases in the mismatch repair (MMR) components MSH2 and MSH6. The modest decrease in MSH2, and relatively modest decrease in MSH6, did not seem sufficient to account for the very …
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Development of imidazotetrazines for the treatment of glioblastoma & as synthetic precursors to diazo species
… with concomitant and adjuvant temozolomide (TMZ), a small molecule DNA alkylating agent. The antitumor effect of TMZ is ultimately mediated through methylation of the O6-position of guanine and subsequent mismatch repair (MMR)-dependent cell death. Although TMZ was first synthesized in 1984 …
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Combined chemotherapy and immunotherapy against experimental malignant brain tumors
… surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. One possible therapeutic treatment modality presented here is immunotherapy, either alone or combined with intratumoral TMZ. In this …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… in cancer cells. Finally, Temozolomide (TMZ) is an important drug in the treatment of glioblastomas but its activity is reduced by resistance mechanisms including O6 methyl guanine methyltransferase (MGMT) and mismatch repair (MMR). This thesis has identified analogues of TMZ (EA02-45, …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… in cancer cells. Finally, Temozolomide (TMZ) is an important drug in the treatment of glioblastomas but its activity is reduced by resistance mechanisms including O6 methyl guanine methyltransferase (MGMT) and mismatch repair (MMR). This thesis has identified analogues of TMZ (EA02-45, …
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Developing & applying a miniaturized active microchip device
… utilized chemotherapeutic temozolomide (TMZ) in a 9L rodent glioma model. An activation mechanism based on thermally induced membrane failure was developed and incorporated. The kinetics of TMZ release were validated and quantified in vitro. The safety of implanting the device …
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The Evolution of Glioblastoma: A Single Case Study
… A$>$G transitions, which is a pattern typical of TMZ treatment. The fact that the hypermutation did not appear until the second recurrence raises questions about the mechanism of hypermutation. The therapeutic apoptotic action of TMZ relies on the function of the mismatch repair (MMR) pathway. In …
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An Evaluation of Transforming Growth Factor-β Signalling in Adult Glioblastoma
… which surgery, radiotherapy and temozolomide (TMZ) have been the standard of care for over two decades. Novel therapies are required, with the ubiquitous and essential cytokine, transforming growth factor-beta (TGFβ), being a promising therapeutic strategy of unharnessed potential. Here, the …
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Caractérisation moléculaire des propriétés anticancéreuses du venin d'abeille et de ses composantes majeures chez les glioblastomes multiformes
… des GBM est l’agent alkylant témozolomide (TMZ). Bien qu’il puisse prolonger l’espérance de vie de certains patients, d’autres n’ont malheureusement pas cette opportunité. Cette résistance au TMZ est principalement causée par des mécanismes moléculaires inhibant l’effet du TMZ. Ainsi, …
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Involvement of CD133+ stem cells in the chemoresistance of glioma
… (P>0.05) when treated with temozolomide (TMZ). This indicates that the enriched stem cell population of U87MG cells in the SFM are chemosensitive to TMZ. The 1321N1 cell line did not show any significant difference (P>0.05) in the chemosensitivity in SCM and SFM when treated with either …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
… chemoradiation (CRT) with temozolomide (TMZ), and adjuvant TMZ. Thus, there is an urgent need to develop more therapeutic interventions for GBM to improve the disease prognosis. Our research group at the University of Wolverhampton has been working on repurposing known FDA approved drugs …
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Targeted Inactivation of APE1 Endonuclease by E96A Mutation Sensitizes Pancreatic Ductal Adenocarcinoma to DNA-Damagin Therapy
… to DNA-damaging agents. Temozolomide (TMZ) produced supra-additive tumor suppression when combined with APE1 endonuclease deficiency, with intermediate-dose TMZ in mutant tumors achieving regression comparable to high-dose TMZ in controls. Enhanced sensitivity was also observed with …
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Examining Cellular Interactions and Response to Chemotherapy in The Glioblastoma Perivascular Niche
… effect of chemotherapeutic drugs temozolomide (TMZ) and Avastin® on EC networks, LN229 cell morphology and alignment, cytotoxicity, colocalization, and trans-differentiation. TMZ was observed to primarily affect LN229 cells, with treatment at high concentrations resulting in up to 2.3-fold …
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Effects of Concurrent Radiosensitization and Chemoradiotherapy for Brain Tumors
… resection, chemotherapy and temozolomide (TMZ) as adjuvant therapy. The purpose of this work is to improve treatment outcomes for highly radioresistant and chemoresistant cancers employing nanoparticle mediated radiosensitization and chemoradiotherapy. Methods: We are using nanoparticle …
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Curcumin as a therapeutic agent for the treatment of rheumatoid arthritis and cancer
… cells were treated with curcumin and TMZ, individually and in combination. Curcumin lowered the expression of 10 candidate genes compared to TMZ which downregulated 8. Combination treatment was the most effective as it decreased the expression of ANGPTL7, CD248, CH25H, COL14A1, CXCL12, …
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Funktionale Relevanz adulter Neurogenese im Hippokampus der Maus
… Applikation des Zytostatikums Temozolomid (TMZ) als Methode ohne das Auftreten negativer Nebenwirkungen erfolgreich etabliert werden. Als Paradigma zur Testung hippokampusabhängigen räumlichen Lernens diente die Morris Water Maze (MWM) unter Verwendung eines Umkehrlernprotokolls, wodurch …
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