Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 155 for “"TME"”.
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Preservazione della funzione genito-urinaria post-operatoria nei pazienti sottoposti a TME con tecnica robotica per neoplasie rettali
… accidentali del plesso ipogastrico in corso di TME, di conseguenza vi è un¿altra frequenza di disfunzioni genito urinarie dopo chirurgia rettale. La chirurgia robotica offre al chirurgo una visione tridimensionale, stabile e ad alta definizione del campo operatorio e consente un controllo molto …
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Improving the cold temperature properties of tallow-based methyl ester mixtures using fractionation, blending, and additives
… feedstocks. However, tallow methyl ester (TME) has the major disadvantage of poor cold temperature properties. Cloud point (CP) is an standard industry metric for evaluating the cold temperature performance of biodiesel and is directly related to the thermodynamic properties of the fuel's …
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Computational profiling of the tumour immune microenvironment
… collectively termed the tumour microenvironment (TME). Single-cell RNA sequencing has offered unparalleled insights in different and rare cell populations. However, bulk RNA-seq remains a cost-effective and widely-used approach to analyse large clinically annotated cohorts. Given the ever growing …
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Reprogramming the Tumor Microenvironment in Desmoplastic Tumors to Potentiate Cancer Immunotherapy
… of an immunosuppressive tumor microenvironment (TME), driven by a highly desmoplastic stroma in mBC. For my dissertation, I explored strategies to re-engineer the desmoplastic TME to overcome therapeutic resistance to immune checkpoint blockade (ICB), and developed an approach to identify …
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ELUCIDATING THE IMPACT OF ASCITES ON HIGH GRADE SEROUS OVARIAN CANCER THROUGH MULTIPLE IN VITRO PATIENT-SPECIFIC MODELS
… and a dynamic tumor microenvironment (TME). The TME, and particularly ascitic fluid (AF), plays a critical role in OC progression by influencing tumor and stromal cell behavior, promoting metastasis and driving therapy resistance. Current in vitro models often fail to replicate the …
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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation To Promote Immune Suppression
The immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor associated macrophages (TAMs) but not immunostimulatory dendritic cells (DCs) remains unclear. Using multiple murine …
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
… cancer subtypes. The tumor microenvironment (TME) is critical in driving these aggressive breast cancers' clinical phenotype and aggressiveness. Therefore, we explored novel actionable targets and complementary therapies targeting the TME to improve the outcomes of patients with these …
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Investigating the impact of ageing on the tumour microenvironment and its crosstalk with malignant cells in pancreatic cancer
… by an extensive tumour microenvironment (TME), which contributes to disease progression and therapy response. PDAC primarily affects elderly individuals as patients are typically diagnosed when 70 years old or older. While ageing has been shown to impact the TME and progression of other …
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Deconvolution of spatiotemporal transcriptomic heterogeneity in the glioblastoma ecosystem
… within the brain tumor microenvironment (TME). A better understanding of how the tumor cells organize spatially and interact with the TME to promote growth and invasion may reveal opportunities for improved therapeutic strategies. In this thesis, I explore transcriptional heterogeneity …
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Single cell and spatial analysis characterize metabolic DPEP1+ fibroblasts in PDAC
… progression patterns, resists conventional treatments, and poses significant challenges to patient survival, necessitating urgent research and development of novel therapeutic approaches. Understanding cancer-associated fibroblasts (CAF) metabolism reprogramming in PDAC tumor microenvironment …
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Exploiting Multi-Cell Type Cultures to Elucidate Tumor Cell Features That Impact Macrophage Phenotype
… components of the tumor microenvironment (TME) that contribute to tumorigenesis, angiogenesis and metastasis. Macrophages are key regulators of the immune landscape within the TME. The plasticity of macrophage phenotypes in the TME correlates with prognosis of NSCLC. Depending on their …
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Investigating Tumour-Immune Cell Interactions in Paediatric Malignancies
There have been significant successes in the treatment of childhood cancer, with the overall survival rate reaching nearly 80%. However, certain leukaemias and solid tumours, as well as metastatic and relapsed cancers, remain resistant to current therapeutic approaches. These patients endure …
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Prevalencia de morbilidad osteomuscular en una empresa de servicios de seguridad electrónica en Bogotá, 2013
… actualmente los trastornos músculo esqueléticos (TME) han sido reconocidos como la principal causa de morbilidad en el trabajo, dado el porcentaje de ausentismo laboral que representa, generando reducción en la productividad de las industrias. Una visión general de la prevalencia en TME puede …
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Current Practices and Perspectives of Genetic Counselors and Reproductive Endocrinologists Regarding Transfer of Mosaic Embryos
… outcomes after the transfer of mosaic embryos (TME), a mosaic test result can present challenging scenarios for providers and patients. The current landscape of this area of reproductive medicine must be described before a consensus can be determined and areas for improvement can be identified. …
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Rational Engineering of Bacteria and Biohybrids for Enhanced Transport and Colonization in the Tumor Microenvironment
… and transport within the tumor microenvironment (TME), caused by irregular and leaky vasculature, the lack of functional lymphatics, and underscored by the overproduction of extracellular matrix (ECM) proteins such as collagen. Coupled with limited specificity, the high chemotherapeutic doses …
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Quantitative cellular and molecular imaging of the intact tumor microenvironment.
… together compose the tumor microenvironment (TME). The myeloid cells play a major role in TME and can be composed of heterogeneous cells with functions that can be grossly summarized as: (1) Antigen capture for presentation (dendritic cells, DCs) or for degradation (macrophages); (2) Tissue …
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Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer
… disease despite multiple lines of treatment. Recent studies investigating the tumour immune microenvironment have highlighted the prognostic significance of different tumour infiltrating lymphocyte (TIL) subsets and secreted immune factors in HGSC. However, the mechanisms promoting TIL …
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Exploring the immune landscape of the tumour microenvironment in meningiomas and the role of immune infiltration in meningioma models
… however, the role of tumour microenvironment (TME), particularly tumour-associated macrophages (TAMs), in meningiomas remains poorly understood, especially concerning genomic alterations. <br/>Aims: To investigate the immune landscape of meningiomas classified by grades, genotypes and …
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Development of Microfluidic 3D Cell Array with Tumor-Stroma interaction for Cancer Immunotherapy Drug Screening
… model to mimic human tumor microenvironment (TME), which is composed of a variety of different cell types, for immunotherapy validation is difficult, costly, and complicated. There is therefore an unmet need for novel approaches to replicate TME for pre-screening these drug candidates. …
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