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Showing 1 to 20 of 30 for “"TMAO"”.
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Transcriptional Regulation of Shewanella oneidensis Using Native TMAO-Inducible Promoters in a Plasmid-Free System
… gene expression with trimethylamine N-oxide (TMAO). I demonstrate its use in a strain with a TMAO-inducible promoter driving mtr gene expression. qRT-PCR data indicate that the inducible system increases mtr gene expression when the cells are exposed to TMAO. Additionally, TMAO induction of …
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Chronic Treatment of TMAO Undermines Mouse Cardiac Structure and Function in a Sex-specific Manner
… elevated levels of trimethylamine N-oxide (TMAO), a gut-derived metabolite, with adverse outcomes of CVD. As of today, TMAO's effects on cardiac structure and function are not well understood. In this study, both male and female TMAO-treated hearts showed functional deficits based on …
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The Direct Impact of Trimethelamine-N-Oxide on Cardiac Function
… a compound named trimethylamine N-oxide (TMAO) was revealed to be closely related to CVDs. However, the impact of TMAO on cardiovascular health is still full of controversy and the direct impact of TMAO on heart tissue and cardiomyocytes has not been fully understood yet. In the first …
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Trimethylamine-N-oxide reduction by alteromonas spp.
Trimethylamine-N-oxide (TMAO) is a nitrogenous compound widely distributed in marine fish and invertebrates. It has long been known that TMAO is reduced by bacteria during the post mortem spoilage of iced marine fish, but the mechanism involved and the physiological role have remained unknown. …
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Effects of Trimethylamine N-Oxide on Mouse Embryonic Stem Cell Properties
Trimethylamine N-oxide (TMAO) is a metabolite derived from dietary choline, betaine, and carnitine via intestinal microbiota metabolism. In several recent studies, TMAO has been shown to directly induce inflammation and reactive oxygen species (ROS) generation in numerous cell types, resulting in …
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Gut Microbiota-Generated Trimethylamine N-Oxide and Cardiometabolic Health in Humans
… 3 (FMO3) to form trimethylamine N-oxide (TMAO). Elevated TMAO is associated with increased risk of cardiovascular disease and type 2 diabetes; however, the causal nature is unclear. There is also limited evidence supporting the efficacy of strategies to reduce accumulation of TMAO. …
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The Impact of Dietary Fat and Phosphatidylcholine on Increased Trimethylamine-N-oxide Levels
Trimethylamine-N-oxide (TMAO) is an important biomarker of atherosclerosis. TMAO is the product of a hepatic conversion of trimethylamine (TMA). Releasing of TMA moieties is dependent on the adaptation of the gut microbiota to dietary TMA containing substrates such as phosphatidylcholine (PC), …
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Gut Microbiota-Generated Trimethylamine-N-oxide and Cardiometabolic Health in Healthy Adults
… in the liver to form trimethylamine N-oxide (TMAO). As a result, ingestion of PC or choline could increase levels of TMAO. Preclinical studies indicate a role of TMAO in the development of atherosclerosis. Likewise, multiple observations support a potential role of TMAO in the development of …
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Investigation of Microbiome Metabolites and Mitochondrial Function in a model of Non-Alcoholic Fatty Liver Disease
… liver disease (NAFLD). Trimethylamine N-oxide (TMAO) and phenylacetic acid (PAA) are microbiome-derived metabolites that have been associated with early onset of NAFLD. Hypothesising that these metabolites contribute to lipid deposition in the liver by altering hepatic mitochondrial function, we …
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Investigating the Influence of Fresh and Aged Garlic Extracts on the Biosynthesis of Trimethylamine N-Oxide
… reducing the risk marker trimethylamine-N-oxide (TMAO). TMAO production in humans is largely influenced by the metabolic activity of the intestinal bacteria on dietary precursors including L-carnitine. Dietary supplementation of bioactive garlic phytochemical allicin has recently been suggested to …
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Probiotic Supplementation, The Gut Microbiota, and Cardiovascular Health
… of the pro-atherogenic, trimethylamine-N-oxide (TMAO). Together, these changes are hypothesized to accelerate CVD progression. Conversely, administration of gut microbiota modulating agents, such as antibiotics and probiotics, attenuate high fat feeding induced CVD in rodent models. In humans, …
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Roles of cosolvents on protein stability
… cosolvents, urea and trimethylamine N-oxide (TMAO) at atomic level. Urea is widely used as a denaturant in the lab to destabilize native protein conformations. However, the atomic mechanism of this molecule remains a question of debate. To unravel its molecular mechanism, explicit all-atom …
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The Elasmobranch-Microbe Relationship: Trimethylamine n-oxide Synthesis, Urea Hydrolysis, and Microbe-Osmolyte Interactions in the Atlantic Stingray, <i>Dasyatis sabina</i>
… primarily urea and trimethylamine n¬-oxide (TMAO). Despite the abundance of these plasma osmolytes, it is notable that elasmobranchs appear to lack urease and TMA oxidase (Tmase), enzymes that scavenge urea-nitrogen and synthesize TMAO, respectively. However, urease and Tmase are found in …
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UNVEILING THE ADVERSE EFFECTS OF POLYSTYRENE NANOPLASTICS IN THE HUMAN-DERIVED HEPG2-OA STEATOTIC-LIKE MODEL, VALIDATING DYSFUNCTIONAL HUMAN-DERIVED SW872 ADIPOCYTE IN VITRO MODELS FOR THE STUDY OF CARDIOMETABOLIC DISEASES, AND ASSESSING TRIMETHYLAMINE N-OXIDE IN A PLIC STUDY SUB-COHORT
… organismi viventi, e la trimetilammina N-ossido (TMAO), un metabolita derivato dal microbiota intestinale. È stato osservato che le PSNP si accumulano in diversi tessuti e organi, tra cui pareti vascolari, fegato, tessuto adiposo, reni e pancreas, esercitando potenziali effetti avversi con il …
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Noncovalent Interactions Involving Microsolvated Networks Of Trimethylamine N-Oxide
… the important osmolyte trimethylamine N-oxide (TMAO). Vibrational spectroscopy, in this case Raman spectroscopy, is used to interpret the effects of noncovalent interactions by solvation with select hydrogen bond donors such as water, methanol, ethanol and ethylene glycol in the form of slight …
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IMPACT OF CHOLINE SUPPLEMENTATION ON GENETICALLY MODIFIED MICE: NEW INSIGHTS IN THE MODULATION OF CARDIOVASCULAR RISK
… è stata posta sulla trimetilammina-N-ossido (TMAO), metabolita derivante dal metabolismo della colina da parte del microbiota intestinale, i cui livelli plasmatici sono positivamente correlati con l’aumento del rischio di eventi cardiovascolari. Lo scopo di questo progetto è stato quello di …
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Kinetic Characterization of the Coupled Folding and Binding Mechanism of Bacterial RNase P Protein: an Intrinsically Unstructured Protein
… are tightly coupled. Trimethylamine-N oxide (TMAO), an osmolyte that stabilizes the unliganded folded form of the protein, enabled us to study the folding process of P protein in the absence of ligand. Transient stopped-flow kinetic time courses at various final TMAO concentrations showed …
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Health impacts and dietary composition of Paleolithic and Australian Guide to Healthy Eating Diets in Australia
… dietary pattern. Serum trimethylamine-N-oxide (TMAO) arises mainly from colonic fermentation and hepatic conversion of animal protein and is positively associated with cardiovascular disease, but changes to RS intake may alter concentrations. With available literature on the Paleolithic diet …
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I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics
… determined to be 31.6 °C by extrapolation to 0 M TMAO in PBS buffer, which was very close to the measured value of 31.5 °C. The Pro-Pro alkenyl peptide began to show a maximum around 225 nm in the CD spectra when the concentration of TMAO was higher than 2.5 M. After extrapolation to 0 M TMAO, the …
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