Global ETD Search
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Showing 1 to 2 of 2 for “"TLX1"”.
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Characterizing the Role of TLX1 in T-cell Acute Lymphoblastic Leukemia
… of the homeobox family transcription factor TLX15–7 . TLX1 expression has been shown to stop thymocyte differentiation, dysregulate gene expression, and promote oncogenic transformation by accumulating genetic lesions and aneuploidy5,6,8–12. Characterization of TLX1 T-ALLs has suggested …
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Prdm13, a Direct Downstream Target of Ptf1a, Regulates the Balance of Gabaergic Neurons versus Glutamatergic Neurons in the Dorsal Spinal Cord
… near the glutamatergic lineage regulatory genes, Tlx1 and Tlx3, to silence their expression. Prdm13 acts through multiple protein/DNA complexes, including a novel complex with Ascl1, to repress Ascl1 activation of Tlx3. Prdm13 is also sufficient to induce Pax2 and the GABAergic phenotype. This …